Acylation

(′as·ə′lā·shən)

(organic chemistry) Any process whereby the acyl group is incorporated into a molecule by substitution.

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A process in which a hydrogen atom in an organic compound is replaced by an acyl group (RCO, where R = an organic group). The reaction involves substitution by a nucleophile (electron donor) at the electrophilic carbonyl group (C&dbnd;O) of a carboxylic acid derivative. The substitution usually proceeds by an addition-elimination sequence. Two common reagents, with the general formula RCOX, that bring about acylation are acid halides (X = Cl, Br) and anhydrides (X = OCOR). There are also other acylating reagents. The carboxylic acid (X = OH) itself can function as an acylating agent when it is protonated by a strong acid catalyst as in the direct esterification of an alcohol. Typical nucleophiles in the acylation reaction are alcohols (ROH) or phenols (ArOH), both of which give rise to esters, and ammonia or amines (RNH₂), which give amides. See also Acid anhydride; Acid halide; Amide; Amine; Electrophilic and nucleophilic reagents.

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the process of introducing an acyl group into a compound by substitution for a hydrogen atom.
—acylated adj.

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Introduction of an acyl radical into the molecules of a compound.

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