Ademetionine is essential for the formation of glutathione, a water-soluble peptide that helps the body fight free radicals.

Ademetionine has been used successfully to treat depression, arthritis, schizophrenia, liver disease, peripheral neuropathy, and other illnesses.

Ademetionine, also known as SAMe, is a specific form of the amino acid methionine known as S-adenosyl-methionine. The body manufactures it, and it is found in most tissues of the body.

SAMe is not suitable for patients with bipolar disorder, as it may amplify the manic phase of the condition.

The only side effects observed with SAMe in clinical trials were mild gastrointestinal distress.