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agnosia

  (ăg-nō'zhə) pronunciation
n.

Loss of the ability to interpret sensory stimuli, such as sounds or images.

[Greek agnōsiā, ignorance : a-, without; see a–1 + gnōsis, knowledge (from gignōskein, to know).]


 
 

Definition

Agnosia is a neuropsychological disorder characterized by the inability to recognize common objects, persons, or sounds, in the absence of perceptual disability. There are three major types of agnosia: visual agnosia, auditory agnosia, and tactile agnosia. Agnosia is caused by lesions to the parietal and temporal lobes of the brain, regions involved in storing memories and associations of objects. The condition may arise following head trauma or stroke, or following carbon monoxide poisoning or anoxia.

Description

Agnosia, from the Greek "not knowing," describes a collection of disorders where the ability to recognize objects or sounds or retrieve information about them is impaired, in the absence of other perceptual difficulties, including memory, intellectual capabilities, and the capacity for communication. The disorder can affect visual, auditory or tactile object recognition, but visual agnosia is the most common form of the condition, and most often expressed as an inability to recognize people.

Visual Agnosia

In addition to being the most common form of agnosia, visual agnosias are also the best understood. Lissauer was the first scientist to provide a detailed account of agnosia (1888). He hypothesized that disorders in visual object recognition could be classified as either apperceptive agnosia or associative agnosia. This classification continues to be used today although there is some debate as to whether the deficits occur as a dichotomy or as a spectrum.

Apperceptive agnosics can see, but they lack higher-level visual perception, which interferes with object information gathering. Apperceptive agnosics fail shape-recognition and shape-copying tests. In an attempt to copy a drawing of a circle, a patient with apperceptive agnosia my draw a series of concentric scribbles. Conversely, associative agnosics have normal perception, but fail to draw on stored memories or knowledge associated with the object, such as its name, or the way it feels when picked up.

APPERCEPTIVE VISUAL AGNOSIA Carbon monoxide poisoning is a frequent cause of apperceptive visual agnosia. The ensuing brain damage is frequently profuse and located in the posterior region of the brain. Simultanagnosia, a syndrome related to apperceptive visual agnosia, describes a condition where scenes containing multiple objects cannot be interpreted as a whole. Instead patients with simultanagnosia, recognize only portions of the scene at one time, and fail to describe the overall nature of the scene and comprehend its meaning.

Individuals capable of seeing only one object at a time are said to have dorsal simultanagnosia. The condition is associated with lesions in the posterior parietal cortex, which are frequently bilateral. Patients with ventral simultanagnosia retain the ability to recognize whole objects, but the rate of recognition is impaired. The left inferior temporo-occipital cortex is generally implicated in the deficit.

ASSOCIATIVE VISUAL AGNOSIA Even when perception remains intact, some people have difficulty recognizing objects. For these people, who lack language or communication disorders or intellectual impairment, and who are able to create good copies of objects, the deficit lies in retrieving stored information about the object that would permit identification. However, many people can provide semantic information about the object without being able to provide the name. For example, the word "kangaroo" may remain elusive, but descriptors, such as "found in Australia" and "has a pouch" may be offered in its place. Many associative visual agnosics have difficulty recognizing faces (prosopagnosia) or words (pure alexia), others specific types of objects, such as tools, or animals.

Prosopagnosia was first described by Quaglino and Borelli in 1867. Although deficits in face recognition occur in a variety of neurological diseases, including Alzheimer's and Huntington's diseases, Asperger's syndrome and autism, the term is best reserved for situations where impaired face recognition appears in absence of other neurological symptoms. Patients are often uncomfortable in social situations, although many learn to recognize people using other visual cues, such as hairstyles, glasses, or scars.

Prosopagnosia can be diagnosed using the Warrington Memory Test for faces, or the Benton Face Recognition test. Although the latter will not indicate prosopagnosia, failing the test does help quantify the degree of impairment. Neuroimaging of the adult with prosopagnosia often reveals lesions in the lingual and fusiform gyri of the medial occipitotemporal cortex, which are frequently bilateral. Children who have acquired the condition in utero or genetically, however, may not show these cortical lesions.

Auditory agnosia

Auditory agnosics fail to ascribe values to verbal or non-verbal sounds. Individuals with pure word deafness have intact hearing, but are unable to understand the spoken word, typically the result of bilateral trauma to the temporal cortico-subcortical regions of the brain. Nonverbal auditory agnosics fail to associate sounds with specific objects or events, such as a dog's bark or the slamming of a door. In these patients, the lesions tend to locate to the right hemisphere.

Tactile agnosia

Tactile agnosia, also called astereognosis, is often difficult to recognize as we rarely identify objects solely by feel. Information about the object, including its weight, size, and texture are not given any value. Lesions in the somatosensory cortex are thought to be responsible for the condition.

Resources

BOOKS

"Agnosia," Section 14, Chapter 169. In The Merck Manual of Diagnosis and Therapy, Mark H. Beers, and Robert Berkow, eds. Whitehouse Station, NJ: Merck Research Laboratories, 1999.

Farah, M. J. Disorders of Object Recognition and What They Tell us About Normal Vision, 2nd edition. Cambridge, MA: The MIT Press, 1995.

Freinberg, T. E. and M. J. Farah. "Cognitive-Motor Disorders, Apraxias, and Agnosias." In Neurology in Clinical Practice: Principles of Diagnosis and Management, 3rd edition, W. G. Bradley, R. B. Daroff, G. M. Fenichel, et al., eds. Boston, MA: Butterworth Heinemann, 2000.

PERIODICALS

Barton, J. J. S. "Disorders of face perception and recognition." Neurologic Clinics of North America 21 (2003): 521–548.

Hodgson, T. L., and C. Kennard. "Disorders of higher visual function and hemi-spatial neglect." Current Opinion in Neurology 13 (2000): 7–12.

Riddoch, M. J. and G. W. Humphreys. "Visual agnosia." Neurologic Clinics of North America 21 (May 2003): 501–520.

WEBSITES

National Institute of Neurological Disorders and Stroke (NINDS). NINDS Agnosia Information Page.http://www.ninds.nih.gov/health_and_medical/disorders/agnosia.htm.

ORGANIZATIONS

National Eye Institute (NEI), National Institutes of Health. Bldg. 31, Rm. 6A32, Bethesda, MD 20892-2510. (301) 496-52482 or (800) 869-2020. 020@b31.nei.nih.gov. http://www.nei.nih.gov.

National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health. Bldg. 31, Rm. 3C35, Bethesda, MD 20892-2320, (301) 496-7243. nidcdinfo@nidcd.nih.gov. http://www.nidcd.nih.gov.

National Organization for Rare Disorders (NORD). P.O. Box 1968 (55 Kenosia Avenue), Danbury, CT 06813-1968. (203) 744-0100 or (800) 999-NORD (6673); Fax: (203) 798-2291. orphan@rarediseases.org. http://www.rarediseases.org.


Hannah M. Hoag, MSc


 

An impairment in the recognition of stimuli in a particular sensory modality. True agnosias are associative defects, where the perceived stimulus fails to arouse a meaningful state. An unequivocal diagnosis of agnosia requires that the recognition failure not be due to sensory-perceptual deficits, to generalized intellectual impairment, or to impaired naming (as in aphasia). Because one or more of these conditions frequently occur with agnosia, some clinical scientists have questioned whether pure recognition disturbances genuinely exist; but careful investigation of appropriate cases has affirmed agnosia as an independent entity which may occur in the visual, auditory, or somesthetic modalities. See also Aphasia.

The patient with visual object agnosia, though quite able to identify objects presented auditorily or tactually, cannot name or give other evidence of recognizing visually presented objects. Because visual object agnosia is a rather rare disorder, knowledge of its underlying neuropathology is incomplete. Most reported cases have shown bilateral occipital lobe lesions, with the lesion extending deep into the white matter and often involving the corpus callosum. Prosopagnosia is the inability to recognize familiar faces. Persons well known to the individual before onset of the condition, including members of the immediate family, are not recognized. In many instances, individuals fail to recognize picture or mirror images of themselves. Isolated impairment of reading is frequently considered to be an exotic form of aphasia. Logically, however, it may be considered as a visual-verbal agnosia (also referred to as pure word blindness or alexia without agraphia). Individuals with this disorder show a marked reduction in their ability to read the printed word, though their writing and other language modalities remain essentially intact.

The term auditory agnosia is most often used to indicate failure to recognize nonverbal acoustic stimuli despite adequate hearing sensitivity and discrimination. In most well-documented cases of agnosia for sounds, the subjects have had bilateral temporal lobe lesions. Auditory-verbal agnosia (or pure word deafness) is a disturbance in comprehension of spoken language, in the presence of otherwise intact auditory functioning and essentially normal performance in other language modalities. The person's speech expression is remarkably intact in comparison with the gross impairment in understanding speech. Like its visual analog, visual-verbal agnosia, this is a disconnection syndrome. It is produced by damage to the left primary auditory cortex (or the tracts leading to it) coupled with a lesion to the corpus callosum. Phonagnosia is a disturbance in the recognition of familiar voices. The person has good comprehension of what is spoken, but the speaker cannot be identified. See also Brain; Hearing (human); Hemispheric laterality; Psychoacoustics; Vision.


 
(agnō′zē-ə, -zhə)
n

A loss of ability to recognize common objects (that is, a loss of ability to understand the significance of sensory stimuli [for example, tactile, auditory, or visual] resulting from brain damage).

 
Obscure Words: agnosia


/ag NO zhia/  Psych.  Freud's term for loss of perception; e.g., prosopagnosia - an inability to recognize faces, autotopagnosia - the inability to localize and name the part's of one's own body
 
Wikipedia: agnosia
Agnosia
Classification & external resources
ICD-10 R48.1
ICD-9 784.69
MeSH D000377

Agnosia (a-gnosis, "non-knowledge", or loss of knowledge) is a loss of ability to recognize objects, persons, sounds, shapes, or smells while the specific sense is not defective nor is there any significant memory loss. It is usually associated with brain injury or neurological illness, particularly after damage to the temporal lobe.

Types

  • Visual agnosia is associated with lesions of the left occipital lobe and temporal lobes. Many are the inability to recognize objects. Subtypes:
    • Form agnosia: Patients perceive only parts of details, not the whole object.
    • Finger agnosia is the inability to distinguish the fingers on the hand. It is present in lesions of the dominant parietal lobe, and is a component of Gerstmann syndrome.
    • Simultanagnosia: Patients can recognize objects or details in their visual field, but only one at a time. They cannot make out the scene they belong to or make out a whole image out of the details. They literally cannot see the forest for the trees. Simultanagnosia is a common symptom of Balint's syndrome.
    • Associative agnosia: Patients can describe visual scenes and classes of objects but still fail to recognize them. He may, for example, know that a fork is something you eat with but may mistake it for a spoon. Patients suffering from associative agnosia are able to reproduce an image through copying.
    • Apperceptive agnosia: Patients are unable to distinguish visual shapes and so have trouble recognizing, copying, or discriminating between different visual stimuli. Unlike patients suffering from associative agnosia, those with apperceptive agnosia are unable to copy images.
    • Mirror agnosia: Patients cannot recognize objects or activity on either their left or right field of view. Impairment can vary from mild inattention to complete inability to perform spatial reasoning with regard to the afflicted side. The disorder takes its name from an experiment in which a patient was shown objects reflected in a mirror and saw them, but was unable to find them when prompted.
    • Semantic agnosia:
    • Agnosic alexia: Inability to recognize text.
    • Color agnosia: There is a distinction between color perception versus color recognition. Central achromatopsia and color blindness refer to deficiency in color perception.
    • Prosopagnosia also known as faceblindness and facial agnosia: Patients cannot consciously recognize familiar faces, sometimes even including their own. This is often misperceived as an inability to remember names. People with PA frequently (but not always) also suffer from topographical agnosia (poor sense of direction, get lost easily), automobilia agnosia (an inability to recognize cars), expressive agnosia (an inability to perceive people's moods from their facial expressions), verbal agnosia (see below) and possibly dyscalculia (poor with numbers).
  • Auditory agnosia refers to similar symptoms for sounds. This term is sometimes used with the limited reference to environmental, nonverbal auditory cues, as separate from verbal agnosia There is a weakly defined link between these terms and CAPD/APD (originally Central Auditory Processing Disorder, the term Auditory Processing Disorder is now preferred).
    • Verbal auditory agnosia or Pure word deafness or simply word deafness: agnosia connected to verbal information. Patients may hear the sounds of the words, but they don't understand what they mean or can't recognize them as words.
    • Amusia or Receptive amusia is agnosia for music. It involves loss of the ability to recognize musical notes, rhythms, and intervals and the inability to experience music as musical.
    • Cortical deafness refers to people who do not respond to any auditory information but whose hearing is intact.
    • Phonagnosia is the inability to recognize familiar voices, even though the hearer can understand the words used.
  • Somatosensory agnosia or Astereognosia [clarify] is connected to tactile sense - that is, touch. Patient finds it difficult to recognize objects by touch based on its texture, size and weight. However, they may be able to describe it verbally or recognize same kind of objects from pictures or draw pictures of them. Thought to be connected to lesions or damage in somatosensory cortex.

Causes

Agnosia can result from strokes, dementia, or other neurological disorders. It may also be trauma-induced by a head injury, or hereditary. Until the 1990s, it was not believed to be genetic[citation needed], but that view has changed.

Treatment

For all practical purposes, there is no direct cure. Patients may improve if information is presented in other modalities than the damaged one. In some cases, occupational therapy or speech therapy can improve agnosia, depending on its etiology.

See also

External links


 
 

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Copyrights:

Dictionary. The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2007, 2000 by Houghton Mifflin Company. Updated in 2007. Published by Houghton Mifflin Company. All rights reserved.  Read more
Neurological Disorder. Gale Encyclopedia of Neurological Disorders. Copyright © 2005 by The Gale Group, Inc. All rights reserved.  Read more
Sci-Tech Encyclopedia. McGraw-Hill Encyclopedia of Science and Technology. Copyright © 2005 by The McGraw-Hill Companies, Inc. All rights reserved.  Read more
Dental Dictionary. Mosby's Dental Dictionary. Copyright © 2004 by Elsevier, Inc. All rights reserved.  Read more
Obscure Words. © 2008 by Michael A. Fischer http://home.comcast.net/~wwftd Read more
Wikipedia. This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Agnosia" Read more

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