agranulocytosis

Agranulocytosis (a, from the Greek, meaning without; granulocyte, a particular kind of cell; osis, from the Greek, meaning condition [esp. disorder]) is an acute condition involving a severe and dangerous leukopenia, particularly of neutrophils, causing a neutropenia in the circulating blood.^[1][2]

Concentrations of granulocytes (a class that includes neutrophils, basophils, and eosinophils) can often drop to below 500 cells/mm³ of blood), less than one-sixth of the reference value of 3-10 x 10³ cells/mm³.^{[citation needed]}

Signs and symptoms

Agranulocytosis may be asymptomatic, but may clinically present with sudden fever, rigors and sore throat. Infection of any organ may be rapidly progressive (e.g., pneumonia, urinary tract infection). Septicemia may also progress rapidly.

A large number of drugs have been associated with agranulocytosis, including antiepileptics, antithyroid drugs (carbimazole, methimazole, and propylthiouracil), antibiotics (penicillin, chloramphenicol and co-trimoxazole), cytotoxic drugs, gold, NSAIDs (indomethacin, naproxen, phenylbutazone), mebendazole, the antidepressant mirtazapine, and some antipsychotics (the atypical antipsychotic clozapine)^[3]. Clozapine users in the US must be nationally registered for monitoring of low WBC and absolute neutrophil counts (ANC). Although the reaction is generally idiosyncratic rather than proportional, experts recommend that patients be told about the symptoms of agranulocytosis-related infection, such as a sore throat and a fever.^{[citation needed]}

Neutropenia and agranulocytosis are associated with gum disease such as gingival bleeding, saliva increase, halitosis, osteoporosis, and destruction of periodontal ligament.^{[citation needed]}

Diagnosis

The diagnosis is made on a complete blood count, a routine blood test performed frequently in general practice and especially in hospital setting.

The neutrophil count is below 500 and can reach 0 cells/mm3. Other series are normally spared. The myelogram (bone marrow sample) shows normocellular blood marrow with promyelocyte's maturation arrest. To formally diagnose agranulocytosis, other pathologies with a similar presentation must be excluded, such as aplastic anemia, paroxysmal nocturnal hemoglobinuria, myelodysplasia and leukemias. This requires a bone marrow examination.

Classification

The terms agranulocytosis, granulocytopenia and neutropenia are often used interchangeably, although agranulocytosis implies a more severe deficiency than granulocytopenia, and neutropenia implies a deficiency of neutrophils only. To be precise, neutropenia is the term used to describe absolute neutrophil counts (ANC) <500 per microlitre, whereas agranulocytosis is reserved for cases with ANC <100 per microlitre. The following terms can be used to specify the type of granulocyte referenced:

• neutrophil -- neutropenia
• eosinophil -- eosinopenia - not commonly used
• basophil -- basopenia - very rarely used

Treatment

In patients that have no symptoms of infection, management consists of close monitoring with serial blood counts, withdrawal of the offending agent (e.g., medication), and general advice on the significance of fever.

Infection in patients with low white blood cell counts is usually treated urgently, and usually includes a broad-spectrum penicillin or cephalosporin (piperacillin-tazobactam, ceftazidime or ticarcillin clavulanate), or meropenem in combination with gentamycin or amikacin.^{[citation needed]}

If the patient remains febrile after 4-5 days and no causative organism for the infection has been identified, antibiotics are, in general, changed to a glycopeptide (e.g., vancomycin), and subsequently an antifungal agent (e.g., amphotericin B) is added to the regimen.^{[citation needed]} In agranulocytosis, the use of recombinant G-CSF (filgrastim) often results in hematologic recovery.^{[citation needed]}

Transfusion of granulocytes would have been a solution to the problem. However, granulocytes live only ~10 hours in the circulation (for days in spleen or other tissue), which gives a very short-lasting effect. In addition, there are many complications of such a procedure.

See also

• Complete blood count
• Granulocytosis

References