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agranulocytosis

  (ā-grăn'yə-lō-sī-tō'sĭs) pronunciation
n.

An acute disease marked by high fever and a sharp drop in circulating granular white blood cells. It may be drug-induced or the result of exposure to radiation.


 
 
Dental Dictionary: agranulocytosis
(āgran′yǒǒlōsītō′sis)
n

A decrease in the number of granulocytes in peripheral blood resulting from bone marrow depression by drugs and chemicals or replacement by a neoplasm. Oral lesions are ulceronecrotic, involving the gingivae, tongue, buccal mucosa, or lips. Regional lymphadenopathy and lymphadenitis are prevalent.

Agranulocytosis. (Regezi/Sciubba/Jordan, 2003)

Agranulocytosis. (Regezi/Sciubba/Jordan, 2003)

 
Columbia Encyclopedia: agranulocytosis
(əgrăn'yəlōsītō'sis) , disease in which the production of granulated white blood cells by the bone marrow is impaired. Although the disease may occur spontaneously it is usually induced by exposure to antithyroid drugs, sulfonamides, phenothiazines, chemotherapy, and radiation therapies. Granulocytes protect the body against infectious agents; their depletion results in severe respiratory infections, ulceration of the mouth and colon, high fever, and prostration. These symptoms may occur suddenly or over a period of days or weeks. Penicillin is usually the drug of choice to combat the bacterial invasion. Treatment may require bone marrow transplants to start the production of healthy white blood cells. The fatality rate is high (approaching 80%) in untreated cases, and deaths are common even with antibiotic treatment.


 
Veterinary Dictionary: agranulocytosis

A disease state characterized by a marked reduction in the granulocyte count in the blood and in the body's defenses against bacterial invasion. Called also granulocytopenia. See also feline panleukopenia.

 
Wikipedia: agranulocytosis
Agranulocytosis
Classification & external resources
ICD-10 D70.
ICD-9 288.0

Agranulocytosis (literally meaning an increase of agranulocytes or more commonly, a lack of granulocytes) is an acute condition involving a severe and dangerous leukopenia (reduction in the number of white blood cells) in the body. Concentrations of granulocytes (a class which includes neutrophils, basophils and eosinophils) can often drop to below 500 cells/mm³ of blood), less than a sixth of the reference value of 3-10 x 103 cells/mm³.

Signs and symptoms

Agranulocytosis may be asymptomatic, but may clinically present with sudden fever, rigors and sore throat. Infection of any organ may be rapidly progressive (e.g. pneumonia, urinary tract infection). Septicemia may also progress rapidly.

A large number of drugs have been associated with agranulocytosis, including antiepileptics, antithyroid drugs (carbimazole and methimazole), metamizole, antibiotics (penicillin, chloramphenicol and co-trimoxazole), cytotoxic drugs, gold, NSAIDs (indomethacin, naproxen, phenylbutazone) some antipsychotics (the atypical antipsychotic clozapine), whose users must be nationally registered for monitoring of low WBC and absolute neutrophil counts (ANC), and the antidepressant mirtazapine (Remeron). Although the reaction is generally idiosyncratic rather than proportional, experts recommend that patients be told about the symptoms of agranulocytosis (generally starting with a sore throat and a fever).[citation needed]

Neutropenia and agranulocytosis are associated with gum disease.[citation needed]

Diagnosis

The diagnosis is made on a complete blood count, a routine blood test performed frequently in general practice and especially in hospital setting.

The neutrophil count is below 500 and can reach 0 cells/mm3. Other series are generally spared. The myelogram (bone marrow sample) shows normocellular blood marrow with promyelocyte's maturation arrest. To formally diagnose agranulocytosis, other pathologies with a similar presentation must be excluded, such as aplastic anemia, paroxysmal nocturnal hemoglobinuria, myelodysplasia and acute leukemia; this generally requires a bone marrow examination.

Classification

The terms "agranulocytosis", granulocytopenia, and neutropenia are often used interchangeably, although "agranulocytosis" implies a more severe deficiency than "granulocytopenia", and "neutropenia" implies a deficiency of neutrophils only. To be precise, neutropenia is the term used to describe absolute neutrophil counts (ANC) <500 per microlitre. Whereas, agranulocytosis is reserved for cases with ANC <100 per microlitre. The following terms can be used to specify the type of granulocyte referenced:

Treatment

In patients who have no infective symptoms, management consists of close moniting with serial blood counts, withdrawal of the offending agent (e.g. medication) and general advice on the significance of fever.

Infection in patients with low white blood cell counts is generally treated urgently, and usually includes a broad-spectrum penicillin or cephalosporin (piperacillin-tazobactam, ceftazidime or ticarcillin clavulanate) or meropenem in combination with gentamycin or amikacin.[citation needed]

If the patient remains febrile after 4-5 days and no causative organism for the infection has been identified, antibiotics are generally changed to a glycopeptide (e.g. vancomycin), and subsequently an antifungal agent (e.g. amphothericin B) is added to the regimen.[citation needed] In agranulocytosis, the use of recombinant G-CSF (filgrastim) often results in hematologic recovery.[citation needed]

See also


 
 

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Copyrights:

Dictionary. The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2007, 2000 by Houghton Mifflin Company. Updated in 2007. Published by Houghton Mifflin Company. All rights reserved.  Read more
Dental Dictionary. Mosby's Dental Dictionary. Copyright © 2004 by Elsevier, Inc. All rights reserved.  Read more
Columbia Encyclopedia. The Columbia Electronic Encyclopedia, Sixth Edition Copyright © 2003, Columbia University Press. Licensed from Columbia University Press. All rights reserved. www.cc.columbia.edu/cu/cup/  Read more
Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.  Read more
Wikipedia. This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Agranulocytosis" Read more

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