Ludwig Karl Martin Leonhard Albrecht Kossel (September 16, 1853 – July 5, 1927) was a German medical doctor.
Biography
Kossel was born in Rostock as the son of Prussian
consul Albrecht Kossel and his wife Clara. In 1872, Kossel went to the University of Strasbourg to study
medicine, where he visited lectures of Anton de Bary,
Waldeyer, Kundt, Baeyer and Felix
Hoppe-Seyler. He graduated in 1878 at the University
of Rostock.
Kossel was awarded the 1910 Nobel Prize
in Physiology or Medicine for research in cell biology, especially proteins and nucleic acids. He also discovered the amino acid
histidine (1896), thymic acid and agmatine (1910).
Kossel's field of work was physiological chemistry, especially the chemistry of tissues and cells. He began his investigations into the
constitution of the cell nucleus at the end of 1880, and in
the nineties he began his investigations of proteins, the alterations in proteins during transformation into peptone, the effects of a phenetol diet on the urine, the peptonic components of the cells. In 1896 he discovered histidine, then worked out the classical method for the quantitaive separation of the hexone bases. With his distinguished English pupil Henry Drysdale
Dakin he investigated arginase, the ferment which hydrolyses arginine into urea and ornithine, and later he
discovered agmatine in herring roe and devised a method for preparing it.
One of Kossel's students was American biochemist
Edwin B. Hart, who would later return to the United
States to participate in the "Single-grain experiment" (1907-1911) and be part of research teams that would determine the nutritive causes of anemia and goiter.
Kossel had one daughter and one son, Walther (1888-1956), who was a prominent Professor of Theoretical Physics at Danzig Institute of Technology
(1932-1945).
Selected works
- Untersuchungen über die Nukleine und ihre Spaltungsprodukte ("Investigations into the nucleins and their cleavage
products", 1881)
- Die Gewebe des menschlichen Körpers und ihre mikroskopische Untersuchung ("The tissues in the human body and their
microscopic investigation", 1889-1891)
- Leitfaden für medizinisch-chemische Kurse ("Textbook for medical-chemical courses", 1888)
- Die Probleme der Biochemie ("The problems of biochemistry", 1908
- Die Beziehungen der Chemie zur Physiologie ("The relationships between chemistry and physiology", 1913)
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