The course of Alexander disease is generally one of regression
and progressive neurologic degeneration. Prognosis varies according
to the form of the disease.
The course of Alexander disease is generally one of regression
and progressive neurologic degeneration. Prognosis varies according
to the form of the disease.
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The main features of Alexander disease are progressive mental
impairment and loss of motor control.
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Most cases of Alexander disease are genetic, caused by a
dominant mutation (change) in the glial fibrillary acidic protein
(GFAP) gene on chromosome 17.