Alexis Carrel (June 28, 1873 - November 5, 1944) was a French surgeon,
biologist and eugenicist, who was awarded the Nobel Prize in Physiology or Medicine in 1912. He was also a member of
Jacques Doriot's Parti Populaire
Français (PPF), the most collaborationist party during Vichy France.
Biography
Born in Sainte-Foy-lès-Lyon, next to Lyon, Carrel practiced in
France and in the United States at the University of Chicago and the
Rockefeller Institute for Medical Research. He developed new techniques in
vascular sutures and was a pioneer in transplantology and thoracic surgery. Alexis Carrel was also
a member of learned societies in the U.S., Spain, Russia, Sweden, the Netherlands,
Belgium, France, Vatican City, Germany, Italy and Greece and received honorary doctorates from Queen's University of Belfast, Princeton
University, California, New York, Brown University and Columbia University. He collaborated with American physician Charles Claude Guthrie in work on vascular suture and the transplantation of blood vessels and
organs, and Carrel was awarded the 1912 Nobel Prize in Physiology or
Medicine for these efforts.[1] Due to his membership
of the collaborationist PPF and of his role in implementing eugenics policies during Vichy France, he was accused after the war
of collaborationism, but died before the trial.
Contributions to science
Suturing blood vessels
During the First World War (1914-1918), Carrel and the English chemist Henry Drysdale Dakin developed the Carrel-Dakin method of treating wounds with a disinfectant
solution based on chlorine (Dakin's solution) which, preceding the development of antibiotics, was a major medical advance in the care of traumatic wounds. For this, Carrel was awarded the
Légion d'honneur.
Organ transplants
Carrel co-authored a book with famed pilot Charles A. Lindbergh, The Culture of
Organs, and worked with Lindbergh in the mid-1930s to create the "perfusion pump," which allowed living organs to exist
outside of the body during surgery. The advance is said to have been a crucial step in the development of open-heart surgery and organ transplants, and to have laid the
groundwork for the artificial heart, which became a reality decades later[5]. Some critics of
Lindbergh claimed that Carrel overstated Lindbergh's role to gain media attention,[2] but other sources say Lindbergh played an important role in developing the device[6][7]. Both Lindbergh and Carrel appeared on
the cover of Time magazine on June 13, 1938.
Cellular Senescence
Carrel was also interested in the phenomenon of senescence, or aging. He claimed that all
cells continued to grow indefinitely, and this became a dominant view in the early twentieth century.[3] Carrel was especially famous for an
experiment[4] begun on January
17, 1912. To defend his idea, Carrel placed tissue cultured from an embryonic chicken heart in a stoppered Pyrex flask of his own design, and
maintained the living culture for over 20 years with regular supplies of nutrient. This was longer than a chicken's normal
lifespan. The experiment, which was conducted at the Rockefeller Institute for Medical
Research, attracted considerable popular and scientific attention.
Carrel's famous experiment was never fully replicated (although other researchers obtained mutated "immortal" strains), and in
the 1960s research by Leonard Hayflick and Paul
Moorhead proposed that earlier researchers were wrong, and that differentiated
cells can only undergo a limited number of divisions before dying. This is known as the Hayflick limit, and is now a pillar of biology.[3]
It is not certain how Carrel obtained his anomalous results. Leonard Hayflick
suggests that the daily feeding of nutrient was continually introducing new living cells to the alleged immortal culture.[5] J. A. Witkowski has argued that,[6] while "immortal" strains of visibly mutated cells have been obtained by other
experimenters, a more likely explanation is deliberate introduction of new cells into the culture, possibly without Carrel's
knowledge.[7]
Honors
In 1972, the Swedish Post Office honored Carrel with a stamp that was part of its Nobel stamp series.[8] In 1979, the lunar
crater Carrel was named after him as a tribute to his scientific
breakthroughs.
In February 2002 the Medical University of South Carolina at Charleston, within the celebrations for the Lindbergh 100th
birthday established the Lindbergh-Carrel Prize[8], given to major contributors to "development of perfusion and bioreactor technologies for organ
preservation and growth". M. E. DeBakey and 9 other scientists[9] received the prize, a bronze statuette named "Elisabeth" [10] after Elisabeth Morrow, sister of
Lindbergh's wife Anne Morrow, died due to heart disease. Lindbergh in fact was disappointed that contemporary medical technology
could not provide an artificial heart pump which would allow for heart surgery on her and that gave the occasion for the first
contact between Carrel and Lindbergh.
"Man, The Unknown" (1935)
In 1935, Carrel published a best-selling book titled L'Homme, cet inconnu (Man, The Unknown) which advocated, in
part, that mankind could better itself by following the guidance of an elite group intellectuals, and by implementing a regime of
enforced eugenics. Sociologist Roger Caillois quoted and paraphrased L'Homme, cet inconnu in The Edge of Surrealism: "
'(p)resent-day proletarians owe their status to inherited intellectual and physical defects'
(sancta simplicitas). And he [Carrel] suggests that this state of affairs should be accentuated through appropriate measures, so
as to correlate social and biological inequalities more precisely. Society would then be directed by a hereditary aristocracy
composed of descendants from the Crusaders, the heroes of the Revolution, the great criminals, the financial and industrial
magnates" (p. 360).
Carrel advocated the use of gas chambers to rid humanity of "inferior stock", thus
endorsing the scientific racism discourse. His
endorsement of this idea began in the mid-1930s, prior to the Nazi implementation of such
practices in Germany. In the 1936 German introduction of his book, at the publishers request, he added the following praise of
the Nazi regime which did not appear in the editions in other languages:
"(t)he German government has taken energetic measures against the propagation of the defective, the mentally diseased, and
the criminal. The ideal solution would be the suppression of each of these individuals as soon as he has proven himself to be
dangerous."[9]
Carrel also wrote:
"(t)he conditioning of petty criminals with the whip, or some more scientific procedure, followed by a short stay in
hospital, would probably suffice to insure order. Those who have murdered, robbed while armed with automatic pistol or machine
gun, kidnapped children, despoiled the poor of their savings, misled the public in important matters, should be humanely and
economically disposed of in small euthanasic institutions supplied with proper gasses. A similar treatment could be
advantageously applied to the insane, guilty of criminal acts.".[10]
Alexis Carrel under Vichy
In 1937, Carrel joined Jean Coutrot’s Centre d’Etudes des Problèmes Humains - Coutrot’s
aim was to develop what he called an "economic humanism" through "collective thinking." In 1941, through connections to the
Pétain cabinet (specifically, French industrial physicians André Gros and Jacques Ménétrier) he went on to advocate for the creation of the Fondation Française pour
l’Etude des Problèmes Humains (French Foundation for the Study of Human Problems) which was created by decree of the collaborationist Vichy regime in 1941, and where he served as 'regent'.[11] The foundation was at the origin of the October
11, 1946 law, enacted by the GPRF provisional government, which institutionalized the field of
occupational medicine. It worked on demographics (Robert Gessain, Paul Vincent, Jean Bourgeois), on nutrition (Jean Sutter), on habitation (Jean Merlet) and on the first opinion
polls (Jean Stoetzel). "The foundation was chartered as a public institution under the joint supervision of the ministries
of finance and public health. It was given financial autonomy and a budget of forty million francs—roughly one franc per
inhabitant—a true luxury considering the burdens imposed by the German Occupation on the nation’s resources. By way of
comparison, the whole Centre National de la Recherche
Scientifique (CNRS) was given a budget of fifty million francs."[12]
According to Gwen Terrenoire, writing in Eugenics in France (1913-1941) : a review of research findings, "The
foundation was a pluridisciplinary centre that employed around 300 researchers (mainly statisticians, psychologists, physicians)
from the summer of 1942 to the end of the autumn of 1944. After the liberation of
Paris, Carrel was suspended by the Minister of Health; he died in November 1944, but the Foundation itself was "purged",
only to reappear in a short time as the Institut national d’études
démographiques (INED) that is still active."[13]
Although Carrel himself died on November 5, 1944, most members
of his team did move to the INED, which was led by famous demographist Alfred Sauvy, who coined the expression "Third World". Others joined
Robert Debré's "Institut national d'hygiène" (National
Hygiene Institute), which later became the INSERM.
1990s-2000s debates concerning Carrel
Some scholars, such as Lucien Bonnafé, Patrick Tort and
Max Lafont have accused Carrel of responsibility for the execution of thousands of mentally ill
or impaired patients under Vichy. They argue that this policy was inspired by Carrel's advocacy of eugenics.
Carrel's association with Vichy, and the harshness of his advocacy for eugenics, has led to his descent from fame to
obscurity. In recent years, Jean-Marie le Pen, leader of the far-right
Front National party ("National Front"), has become an advocate for Carrel,
referring to him as "the first environmentalist, or, if you will, the first modern
ecologist, precisely because he committed himself to defining the relationships of natural harmony.".[14] His writings on eugenics are studied "avidly in the training camps of the
National Front".[15]
In the 1990s, the attention the National Front's support brought to Carrel's fascist
associations and controversial views created a series of controversies with respect to streets and institutions named in honor of
Carrel. Over 20 French cities and towns, including Paris, renamed streets previously named for Carrel. The controversy came to a
head in Lyon, the city next to his birthplace, where he studied medicine. One of the four medicine faculties of the university
Claude Bernard - Lyon I had been named in his honor in 1968. Lyon libération questioned
the wisdom of this. In response to this, in May 1995, the Palais des Congrès of Lyon hosted a conference on Carrel and
scientific racism at which several of the participants accused the inquiry commission
of whitewashing the controversial scientist. In early 1996, after five years of embarrassing
publicity, the governing board of the University of Lyon decided to rename its school of medicine after René Laënnec, inventor of the stethoscope."[16]
In the United States as well as in France, the 1990s were not kind to Carrel's reputation. In an interview for
PBS' The American
Experience, historian Arthur Schlesinger, Jr. blamed Carrel for
Charles Lindbergh's increasing racism in the 1930s. Schlesinger stated in response to
a question concerning the source of Lindbergh's beliefs on this subject: "I suppose he got a lot of it from Alexis Carrel, the
French biologist who had a kind of racial mysticism of a sort."[17]
Carrel's influence in traditional circles has declined despite the immense influence he has enjoyed over French popular
additudes to marriage and inherited disease.Streets and a medical faculty bearing his name have been changed and after a recent
political- philosophical exchange his theories were rebutted by the archbishop of Paris, Monseigneur André Vingt- Trois.
A Source of Inspiration for Islamists
Whereas the writings of Carrel are at present almost forgotten in the West they were one of the most important elements in the
formulation of Islamist ideology. Authors like Sayyid
Qutb, Ali Shariati or Hadi Mudarrisi quote him as a
"crown witness" against the decadent and materialist Western civilisation.
References
- ^ Nobelprize.org
- ^ (Wallace, American Axis p. 101)
- ^ a b Fossel, Michael B. (2004). Cells, Aging, and Human Disease. Oxford University Press. ;
page 24.
- ^ A. Carrel, On the permanent life of tissues outside of the organism,
Journal of Experimental Medicine, (1912) 15 pp.516-528.
- ^ Hayflick, L. (Nov 1997). "Mortality and Immortality at the Cellular Level. A Review.". Biochemistry (Mosc)
62 (11): 1180–1190.
- ^ Witkowski, JA (1980). "Dr. Carrel's immortal
cells.". Medical History 24 (2): 129–142.
- ^ Witkovsky explanation is actually based on the account of a visiting
medical researcher, Ralph Buchbaum, who reports being told by a technician in Carrel's lab "Dr. Carrel would be so upset if we
lost the strain, we just add a few embryo cells now and then". After the first six months, Carrel's colleague Albert Ebeling had
actually taken charge of the cultures and published several papers about their development, until they were eventually discarded
in 1946. Witkowsky, in "Dr. Carrel's immortal cells", op. cit., quotes Buchbaum's account. At the end Buchbaum writes that "I
told this story, of my visit to Carrel's laboratory, to various people. Dr. Bloom (Buchbaum's director of research in
Chicago)refused to believe it. Others chuckled gleefully. Dr. Carrel was to blame only in that he did not keep on top of what
was really going on in the laboratory (mostly, he wrote the papers). Dr. Parker and Dr. Ebeling probably suspected something,
hence the "retirement". In the interest of truth and science, the incident should have been thoroughly investigated. If it had
been, some heads might have rolled, sacrificed to devotion to a wrong hypothesis - immortality of cell strains.". Witkowsky also
reports a Dr. Margaret Murray telling him that "one of Carrel's technicians of that time was passionately anti-fascist and
detested Carrel's political and social ideas" and expressing her belief that "that this technician would willingly have
discredited Carrel scientifically if possible.".
- ^ [1]
- ^ Quoted in Reggiani, p. 339
- ^ quoted on p. 11 of Szasz as A.Carrel, Man, The Unknown (New York,
Harper & Row, 1939), pp. 299-302, 318-319.
- ^ (see Andrés Horacio Reggiani, Alexis Carrel, the Unknown: Eugenics and
Population Research under Vichy, as well as Caillois, p. 107)
- ^ (Reggiani) [2]
- ^ Gwen Terrenoire, "Eugenics in France (1913-1941) : a review of
research findings", Joint Programmatic Commission UNESCO-ONG Science and Ethics, 2003)
[3]
- ^ Jean-Marie Le Pen,
L'Espoir 133-134, cited in Golson, Fascism's Return)
- ^ (Lucien Bonnafé and Patrick Tort, L'Homme, cet inconnu? Alexis Carrel,
Jean-Marie le Pen et les chambres a gaz ISBN 978-2907993142)
- ^ [4]
- ^ PBS, interview with Arthur Schlesinger, Jr.
See also
External links
Wikiquote has a collection of quotations related to:
Sources
- Carrel, Alexis. Man, The Unknown. New York and London: Harper and Brothers. 1935.
- Andrés Horacio Reggiani. Alexis Carrel, the Unknown: Eugenics and Population Research under Vichy (FRENCH HISTORICAL
STUDIES 25:2 SPRING 2002)[11]
- Wallace, Max. The American Axis: Henry Ford, Charles Lindbergh, and the Rise of the Third Reich St. Martin's Press,
New York, 2003.
- Szasz, Thomas. The Theology of Medicine New York: Syracuse University Press,
1977.
- Ali, Tariq. Clash of Fundamentalisms Verso, London, 2002
- Choueiri, Youssef. Islamic Fundamentalism Continuum International Publishing Group, London, 2002.
- Walther, Rudolph. Die seltsamen Lehren des Doktor Carrel, DIE ZEIT 31.07.2003 Nr.32 [12]
- Bonnafé, Lucien and Tort, Patrick. L'Homme, cet inconnu? Alexis Carrel, Jean-Marie le Pen et les chambres a gaz
Editions Syllepse, 1996. [13] ISBN
2907993143
- Abu-Rabi, Ibrahim M. Intellectual Origins of Islamic Resurgence, SUNY Press, Albany, 1996
- Azmeh, Aziz (Aziz Al-Azmeh). Islams and Modernities Verso, London, 1993.
- Berman, Paul. Terror and Liberalism W. W. Norton, 2003
- David Zane Mairowitz. "Fascism à la mode: in France, the far right presses
for national purity", Harper's Magazine; 10/1/1997
- Pioneers of Islamic Revival (edited by Ali Rahnema), Zed Books, London 1994
- Schneider, William. Quality and Quantity: The Quest for Biological Regeneration in Twentieth-Century France, Cambridge
Studies in the History of Medicine (chap. 7 French eugenics in the thirties; and 10 Vichy and after)
- Terrenoire, Gwen, CNRS. Eugenics in France
(1913-1941) : a review of research findings Joint Programmatic Commission UNESCO-ONG Science and Ethics,
March 24, 2003 [14]
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