Dictionary:

aminophylline

  (ăm'ə-nŏf'ə-lĭn)

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A theophylline derivative, C₁₆H₂₄N₁₀O₄, used as a bronchodilator in the treatment of bronchial asthma, emphysema, and bronchitis.

[AMINO + (THEO)PHYLLINE.]

trade names: Phyl-locontin; drug class: xanthine; action: relaxes smooth muscle of the respiratory system; uses: bronchial asthma, bronchospasm, Cheyne-Stokes respirations.

A water-soluble drug belonging to the methyl xanthines and related to caffeine. It is a derivative of theophylline and has been used as a bronchodilator to relieve asthmatic attacks. It is not on the World Anti-Doping Agency's 2005 Prohibited List, although it can have harmful side-effects on the cardiovascular system.

A mixture of theophylline and ethylenediamine; used as a respiratory stimulant, smooth muscle relaxant, myocardial stimulant and diuretic. Administration of the drug may be by mouth, intramuscularly, intravenously or rectally.

Aminophylline
Systematic (IUPAC) name
1,3-dimethyl-7H-purine-2,6-dione; ethane-1,2-diamine
Identifiers
CAS number	317-34-0
ATC code	R03DA05
PubChem	9433
DrugBank	APRD00329
Chemical data
Formula	C16H24N10O4
Mol. mass	420.427 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	60%
Metabolism	?
Half life	7-9 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	P(UK)
Routes	oral, i.v.

Aminophylline is a drug combination that contains theophylline and ethylenediamine in 2:1 ratio.

Properties

It is more soluble in water than theophylline. White or slightly yellowish granules or powder, having a slight ammoniacal odor and a bitter taste. Upon exposure to air, it gradually loses ethylenediamine and absorbs carbon dioxide with the liberation of free theophylline. Its solutions are alkaline. One g dissolves in 25 mL of water to give a clear solution; 1 g dissolved in 5 mL of water crystallizes upon standing, but redissolves when a small amount of ethylenediamine is added. Insoluble in alcohol and in ether.

Mechanism of action

Aminophylline is less potent and shorter-acting than theophylline. Its most common use is in the treatment of bronchial asthma.

Brand names

• Phyllocontin
• Truphylline

External links

Drugs for obstructive airway diseases: asthma/COPD (R03)
Adrenergics, inhalants	Short acting β2-agonists: Salbutamol/Levosalbutamol • Fenoterol • Terbutaline Long acting β2-agonists (LABA): Bambuterol • Clenbuterol • Formoterol • Salmeterol other: Epinephrine • Isoproterenol • Orciprenaline
Glucocorticoids	Beclometasone • Budesonide • Ciclesonide • Fluticasone • Mometasone
Anticholinergics	Ipratropium • Tiotropium
Mast cell stabilizers	Cromoglicate • Nedocromil
Xanthines	Aminophylline • Theobromine • Theophylline
Leukotriene antagonists	Montelukast • Pranlukast • Zafirlukast
Combination products	Budesonide/formoterol • Fluticasone/salmeterol • Ipratropium/salbutamol

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