n.
A theophylline derivative, C16H24N10O4, used as a bronchodilator in the treatment of bronchial asthma, emphysema, and bronchitis.
[AMINO + (THEO)PHYLLINE.]
Dictionary:
am·i·noph·yl·line (ăm'ə-nŏf'ə-lĭn)
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[AMINO + (THEO)PHYLLINE.]
5min Related Video:
aminophylline |
Dental Dictionary:
aminophylline |
trade names: Phyl-locontin; drug class: xanthine; action: relaxes smooth muscle of the respiratory system; uses: bronchial asthma, bronchospasm, Cheyne-Stokes respirations.
Sports Science and Medicine:
aminophylline |
A water-soluble drug belonging to the methyl xanthines and related to caffeine. It is a derivative of theophylline and has been used as a bronchodilator to relieve asthmatic attacks. It is not on the World Anti-Doping Agency's 2005 Prohibited List, although it can have harmful side-effects on the cardiovascular system.
Veterinary Dictionary:
aminophylline |
A mixture of theophylline and ethylenediamine; used as a respiratory stimulant, smooth muscle relaxant, myocardial stimulant and diuretic. Administration of the drug may be by mouth, intramuscularly, intravenously or rectally.
Wikipedia:
Aminophylline |
| Systematic (IUPAC) name | |
|---|---|
| 1,3-dimethyl-7H-purine-2,6-dione; ethane-1,2-diamine | |
| Identifiers | |
| CAS number | 317-34-0 |
| ATC code | R03DA05 |
| PubChem | 9433 |
| DrugBank | APRD00329 |
| ChemSpider | 9062 |
| Chemical data | |
| Formula | C16H24N10O4 |
| Mol. mass | 420.427 g/mol |
| SMILES | eMolecules & PubChem |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 60% |
| Metabolism | ? |
| Half life | 7-9 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
P(UK) |
| Routes | oral, i.v. |
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Aminophylline is a bronchodilator. It is a compound of the bronchodilator theophylline with ethylenediamine in 2:1 ratio. The ethylenediamine improves solubility, and the animophylline is usually found as a dihydrate[1]
Contents |
It is more soluble in water than theophylline. White or slightly yellowish granules or powder, having a slight ammoniacal odor and a bitter taste. Upon exposure to air, it gradually loses ethylenediamine and absorbs carbon dioxide with the liberation of free theophylline. Its solutions are alkaline. One g dissolves in 25 mL of water to give a clear solution; 1 g dissolved in 5 mL of water crystallizes upon standing, but redissolves when a small amount of ethylenediamine is added. Insoluble in alcohol and in ether.
Like other methylated xanthine derivatives, aminophylline is both a
Aminophylline is less potent and shorter-acting than theophylline. Its most common use is in the treatment of bronchial asthma.
Causes bronchodilatation, diuresis, CNS and cardiac stimulation, and gastric acid secretion by blocking phosphodiesterase which increases tissue concentrations of cyclic adenine monophosphate (cAMP) which in turn promotes catecholamine stimulation of lipolysis, glycogenolysis, and gluconeogenesis and induces release of epinephrine from adrenal medulla cells
Aminophylline has shown some promise as a bodyfat reducer when used as a topical cream (sometimes referred to as "cutting gel"). [7] Aminophylline is also a treatment option for anaphylactic shock. [8]
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This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
| Theophylline, Aminophylline | |
| methylxanthine | |
| bronchodilator |
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