| Sports Science and Medicine: angiotensin-converting enzyme |
An enzyme that catalyses the conversion of angiotensin I to angiotensin II. Two forms of the enzyme are coded for by two ACE alleles of different length. Individuals with two copies of the longer allele have been found to gain more muscle mass and lose more body fat during intensive physical training than those with two copies of the shorter allele or one copy of each.
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| Medical Dictionary: di·pep·ti·dyl carboxypeptidase |
A proteolytic enzyme that catalyzes the removal of dipeptides from a variety of compounds, as from angiotensin I as it is converted to angiotensin II. Also called angiotensin-converting enzyme.
| WordNet: angiotensin converting enzyme |
The noun has one meaning:
Meaning #1:
proteolytic enzyme that converts angiotensin I into angiotensin II
| Wikipedia: Angiotensin-converting enzyme |
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Angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
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| Available structures: 1o86, 1o8a, 1uze, 1uzf, 2c6f, 2c6n, 2iul, 2iux, 2oc2 | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbols | ACE; ACE1; CD143; DCP; DCP1; MGC26566 | |||||||||||||
| External IDs | OMIM: 106180 MGI: 87874 HomoloGene: 37351 | |||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 1636 | 11421 | ||||||||||||
| Ensembl | ENSG00000159640 | ENSMUSG00000020681 | ||||||||||||
| Uniprot | P12821 | Q3TU20 | ||||||||||||
| Refseq | NM_000789 (mRNA) NP_000780 (protein) |
NM_009598 (mRNA) NP_033728 (protein) |
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| Location | Chr 17: 58.91 - 58.94 Mb | Chr 11: 105.78 - 105.81 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Angiotensin I-converting enzyme (ACE, EC 3.4.15.1), an exopeptidase, is a circulating enzyme that participates in the body's renin-angiotensin system (RAS), which mediates extracellular volume (i.e. that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. It is secreted by pulmonary and renal endothelial cells and catalyzes the conversion of decapeptide angiotensin I to octapeptide angiotensin II.[1]
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It has two primary functions:
These two actions make ACE inhibition a goal in the treatment of conditions such as high blood pressure, heart failure, diabetic nephropathy, and type 2 diabetes mellitus. Inhibition of ACE (by ACE inhibitors) results in the decreased formation of angiotensin II and decreased metabolism of bradykinin, leading to systematic dilation of the arteries and veins and a decrease in arterial blood pressure. In addition, inhibiting angiotension II formation diminishes angiotensin II-mediated aldosterone secretion from the adrenal cortex, leading to a decrease in water and sodium reabsorption and a reduction in extracellular volume.[4]
The ACE gene, ACE, encodes 2 isozymes. The somatic isozyme is expressed in many tissues, mainly in the lung, including vascular endothelial cells, epithelial kidney cells, and testicular Leydig cells, whereas the germinal is expressed only in sperm.
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 | Sports Science and Medicine. The Oxford Dictionary of Sports Science & Medicine. Copyright © Michael Kent 1998, 2006, 2007. All rights reserved. Read more |
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| Medical Dictionary. The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Read more |
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| WordNet. WordNet 1.7.1 Copyright © 2001 by Princeton University. All rights reserved. Read more |
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| Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Angiotensin-converting enzyme". Read more |
