anorexia

(ăn'ə-rĕk'sē-ə)
n.

1. Loss of appetite, especially as a result of disease.
2. Anorexia nervosa.

[Greek anorexiā : an-, without; see a-¹ + orexis, appetite (from oregein, to reach out for).]

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Key Terms: Anorexia, Cancer, Candidiasis, Chemotherapy, Hypercalcemia, Malignant, Radiation therapy, Satiation.

Definition

Anorexia is characterized by a loss of appetite or lack of desire to eat.

Description

Anorexia is common in cancer patients with reported incidence between 15% and 40%. Primary anorexia is especially prevalent in patients with advanced malignancy, and is frequently a side effect of cancer treatments. Sometimes, early symptoms may remain undiagnosed, or will be masked by a more generalized wasting of the body from chronic disease, known as cachexia.

When patients experience appetite loss, decreased energy consumption will subsequently lead to weight loss. When inadequate calories are consumed, the body may become weaker and less able to tolerate cancer therapies. As body weight decreases, cachexia sets in, and a general failure to thrive may make it more difficult to fight off illness and infection. A poor response to cancer treatments, reduced quality of life, and death may result from substantial weight loss. The spiraling effect of a patient's reluctance to eat is a source of frequent anxiety for caregivers. Weight loss due to anorexia may be temporary or may continue at a life-threatening pace if the patient continues to consume inadequate energy to sustain bodyweight.

Causes

It is normal for a patient to consume less energy when not as active. It is also natural to lose interest in food when individuals are seriously ill. However, it is essential in anorexic patients to consider whether the loss of appetite is the result of a natural disinterest in eating (primary anorexia), or is due to some reversible cause (secondary anorexia).

Secondary anorexia may be a result of:

• nausea with or without fear of vomiting after food consumption
• fatigue
• constipation
• sores in the mouth or mouth pain
• candidiasis
• unappetizing food or change in food preference due to cancer-related treatments
• depression
• odors in the environment, or heightened sensitivity to odors as a result of cancer-related treatments
• early satiation
• metabolic causes such as hypercalcemia and uremia
• radiation therapy or chemotherapy
• drugs such as antibiotics or drugs that can cause nausea

Special Concerns

In order to allow normal tissue repair following aggressive cancer therapies, patients require adequate energy and macronutrients in the form of protein, carbohydrates, and fat. Inadequate consumption of food and/or poor nutrition may impair the ability of a patient to tolerate a specific therapy. If a low tolerance to therapy necessitates a decrease in dose, the therapy's effectiveness could be compromised. Wound healing may also be impaired with poor nutrition and inadequate energy intake.

Individuals who experience pain, nausea, or diarrhea due to the side effects of radiation and chemotherapy may want to discuss treatments options with their doctor to ease these side effects.

Treatments

Dietary tips for managing anorexia

• Serve food when the patient is hungry. A microwave oven often helps.
• Have the patient eat small meals every one to two hours, or time meals corresponding to when the patient feels best (typically early in the day).
• If only a little food is consumed by the patient, it should ideally be high in protein and calories. Avoid empty calories (i.e. foods without protein and nutrients).
• Add extra calories and protein to foods with the use of butter, skim milk powder, commercially prepared protein powder, honey, or brown sugar.
• Try to tempt the patient with tiny portions on small plates.
• Serve food in an attractive manner.
• Food is more likely to be eaten if it is served at frequent intervals unrelated to standard meal times.
• Avoid strong aromas if the patient finds them bothersome.
• Avoid liquids with meals to decrease problems of early satiety
• A small alcoholic drink of the patient's choice may help unless contraindicated.
• Consider flavors, consistency and quantity of food when preparing meals.
• Encourage eating with friends or family members; a meal in a social setting may help the patient to eat.
• Stimulate appetite with light exercise.
• Treat any underlying cause and, if a particular drug appears to be the cause, modify drug regimen.
• Have the patient take medications with high-calories fluids, i.e. commercial liquid supplements unless medication necessitates an empty stomach.

Often, patients may experience difficulty with eating due to upper gastrointestinal blockage such as problems with swallowing, esophageal narrowing, tumor, stomach weakness, paralysis, or other conditions that preclude normal food intake. In those circumstances, enteral nutrition may be administered through a tube into the gastrointestinal tract via the nose, or through surgically placed tubes into the stomach or intestines. If the gastrointestinal tract is working and will not be affected by the cancer treatments, then enteral support by feeding directly into the gut is preferable. Parenteral nutrition (most often an infusion into a vein) can be used if the gut is not functioning properly or if there are other reasons that prevent enteral feeding.

An appetite stimulant may be given such as megestrol acetate or dexamethasone. In clinical trials, both these medications appear to have similar and effective appetite stimulating effects with megestrol acetate having a slightly better toxicity profile. Fluoxymesterone has shown inferior efficacy and an unfavorable toxicity profile.

Alternative and Complementary Therapies

Depression may affect approximately 15-25% of cancer patients, particularly if the prognosis for recovery is poor. If anorexia is due to depression, there are antidepressant choices available through a physician. Counseling may be also be sought through a psychologist or psychiatrist to deal with depression.

St. John's Wort has been used as a herbal remedy for treatment of depression, but it and prescription anti-depressants is a dangerous combination that may cause symptoms such as nausea, weakness, and may cause one to become incoherent. It is important to check with a dietitian or doctor before taking nutritional supplements or alternative therapies because they may interfere with cancer medications or treatments.

Resources

Books

Quillin, Patrick, and Noreen Quillin. Beating Cancer With Nutrition-Revised. Sun Lakes, AZ: Bookworld Services, 2001.

Periodicals

Kant, Ashima, et al. "A Prospective Study of Diet Quality and Mortality in Women." JAMA 283, no. 16 (2000): 2109-2115.

Loprinzi, C.L., et al. "Randomized comparison of megestrol acetate versus dexamethasone versus fluoxymesterone for the treatment of cancer anorexia/cachexia." Journal of Clinical Oncology 17, no. 10 (1999): 3299-306.

Singletary, Keith. "Diet, Natural Products and Cancer Chemoprevention." Journal of Nutrition 130 (2000): 465S-466S.

Willett, Walter C. "Diet and cancer." The Oncologist 5, no. 5 (2000): 393-404.

Organizations

American Institute for Cancer Research. 1759 R Street N.W., Washington, D.C. 20009. (800) 843-8114 or (202) 328-7744. <http://www.aicr.org, e-mail:support@aicr.org>.

The National Cancer Institute (NCI). For information contact the Public Inquiries Office: Building, 31, Room 10A31, 31 Center Drive, MSC 2580, Betheseda, MD 20892-2580 USA. (301) 435-3848, 1-800-4-CANCER. , .

National Center for Complementary and Alternative Medicine (NCCAM). 31 Center Dr., Room #5B-58, Bethesda, MD 20892-2182. (800) NIH-NCAM, Fax (301) 495-4957. .

—Crystal Heather Kaczkowski, MSc.

Lack of appetite.

The eating disorder known as anorexia nervosa is commonly described as "self-starvation." Characteristics of the disorder include a refusal to maintain a minimally normal weight, an intense fear of gaining weight, a disturbed and unrealistic body image, and (in women) the absence of menstrual periods. (Low body weight and/or the cessation of menses distinguishes anorexia from the related disorder, bulimia.) Sufferers may starve themselves simply by restricting the amount of calories or types of food they consume; or there can be a pattern of excessive binge eating followed by purging through self-induced vomiting, inappropriate use of laxatives or enemas, or excessive exercise.

Female gender, low self-esteem, genetics, and social emphasis on thinness all increase the risk for this condition. The consequences of untreated anorexia can be severe, including electrolyte disturbances, heart rhythm abnormalities, and death. Treatment usually involves psychotherapy, medication, nutrition education, and family therapy.

(SEE ALSO: Eating Disorders; Menstrual Cycle; Mental Health; Nutrition; Social Determinants)

— LEONARD J. HAAS; TRISH PALMER

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Anorexia simply means a loss of appetite. Anorexia nervosa is a psychological disturbance that is characterized by an intense fear of being fat. It usually affects teenage or young adult women. This persistent "fat image," however untrue in reality, leads the patient to self-imposed starvation and emaciation (extreme thinness) to the point where one-third of the body weight is lost. There are many theories on the causes of this disease, which is difficult to treat and can be fatal. Between five and 10 percent of patients hospitalized for anorexia nervosa later die from starvation or suicide. Symptoms include a 25 percent or greater weight loss (for no organic reason) coupled with a morbid dread of being fat, an obsession with food, an avoidance of eating, compulsive exercising and restlessness, binge eating followed by induced vomiting, and/or use of laxatives or diuretics.

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Anorexia nervosa (AN), bulimia nervosa (BN), and Eating Disorder Not Otherwise Specified (EDNOS) are three of a spectrum of conditions, commonly known as eating disorders, associated with abnormal eating patterns and a desire to be thin. The abnormal eating patterns in these eating disorders include restriction of food intake, binge eating, and purging with laxatives or by self-induced vomiting. Persons with each of these disorders may go through periods of restriction, binge eating with purging, and binge eating without purging.

The term "eating disorders" for these conditions is both correct and misleading. These disorders center around issues of eating, or, to be more exact, food consumption, and certainly can be qualified as disorders, but more than eating is disordered in these conditions: they are associated with a complex of psychological, physiological, neurological, and hormonal changes, which may be due to the disease itself, or to the changes in weight associated with inappropriate food intakes and energy outputs, or both together.

The notion that thinness is desirable, particularly in women, and that one can never be "too rich or too thin," now permeates Western societies and is becoming increasingly common elsewhere. Teenagers, who are normally preoccupied with body image, and prone to be concerned about gaining weight, may incorrectly perceive themselves as being overweight, because puberty coincides with marked changes in body shape and, for girls, increased body fat content with fat deposition in the hips. Surveys in Western countries have shown that at any one time, up to two-thirds of female high school students either are on a weight loss diet or were on one in the recent past. In the United States, eating disorders seem to be less common among African-American and Asian females than among white females, equally common among Latina females, and surprisingly common among Native Americans. Japan seems to be the country with the highest prevalence of eating disorders. Other countries seem to be catching up, wherever there is access to food and to Western modes of behavior, as exemplified in the media.

Psychological conditions associated with eating disorders include depression, affecting 50–75 percent of people with eating problems; bipolar disorder (manic-depressive illness, 4–15 percent); obsessive-compulsive disorder, affecting as many as 25 percent of people with AN, fewer in those with BN; substance abuse, in up to one-third of patients with BN; and personality disorders, particularly avoidant, in other words, mistrusting, personality. Twenty to fifty percent of patients with BN (and to a lesser extent patients with AN and other eating disorders) have experienced sexual abuse.

A syndrome called "the female athlete triad"—consisting of disordered eating, amenorrhea (disruption of menses), and osteoporosis—is becoming more common as athletic prowess has become desirable for women and as women have better access to athletic facilities in the United States because of Title IX of the Educational Assistance Act (1974). Patients with Type I diabetes mellitus appear to be more prone than the general population to eating disorders, and may use underdosing with insulin to lose weight—when they do not take enough insulin, the body fails to use and store the calories they eat and relies on breakdown of fat and muscle for fuel.

Patients with eating disorders may become parents, may have difficulties nurturing their own children, and may transmit disordered attitudes toward eating to their children. The health care team should take these difficulties into account in treatment plans for both parent and child.

Anorexia Nervosa

Anorexia nervosa (AN) represents an extreme version of the desire for thinness. The term "anorexia" is a misnomer, for a person with this condition does have an appetite, but restricts food intake and denies the desire to eat with the apparent aim of having precise control over body shape and weight. Perhaps the German Pubertätmagersucht—"seeking thinness at puberty"—is a more accurate term, although the disorder has antecedents in childhood and continues into adulthood.

Epidemiology. In the United States, nearly 90 percent of patients with overt, clinically recognized AN are females between the ages of twelve and twenty-three, although younger and older patients as well as males may also develop the disease. The prevalence of AN appeared to rise during the twentieth century, with a lifetime risk among women of 0.5 percent to 3.7 percent and a male to female prevalence ratio between 1 to 6 and 1 to 10. The prevalence among young adolescent males is higher, perhaps reflecting a secular trend or an increasing emphasis on male appearance and "fitness."

The only groups among whom the disease has been recognized are groups who have easy access to food, and among whom being thin is a socially desirable state. However, conditions clinically indistinguishable from AN have existed in Western cultures prior to the twentieth century, particularly during the late Middle Ages and Renaissance, when they were associated with religious asceticism—the professed goal was to demonstrate the person's ability to deny the needs and pleasures of the flesh, rather than to be thin for social acceptance. Similar conditions associated with religious practices also occur in other cultures.

Etiology. Scientific opinion concerning the etiology of AN has vacillated between a biological and genetic explanation and a sociopsychological one. The patient's complaints lie in the psychological realm, while the disease presents features that point to biological and genetic components. There is a significantly higher concordance of anorexia nervosa among monozygotic twins (identical, that is, having the same genes) than among dizygotic twins (fraternal, that is, genetically only as close as a non-twin sibling). Family members have a higher than expected prevalence of other affective (emotional) and addictive disorders.

A host of neurohormonal changes appear once starvation has set in, but it is unclear which of these changes are causal, which are due to progression of the disease, and which are due to semistarvation. A reasonable explanation for the condition is that the person first restrains eating or performs excessive exercise for psychosocial reasons, and then develops a biologically driven self-perpetuating condition.

Development, signs, symptoms and biological findings. Anorexia nervosa develops in three phases, often preceded by picky eating and digestive problems in childhood. In Phase I the patient develops an increased consciousness about physical appearance, coupled with a loss of self-esteem, and begins dieting and exercising to lose weight. While these beliefs and behaviors have become increasingly the norm among adolescent women in developed countries, in certain people it progresses to Phase II.

During Phase II (frank AN) the person develops an "anorectic attitude": an unreasonable fear of eating coupled with pride in the ability to loss weight. Restriction of food intake begins with "fattening," "dangerous" foods such as carbohydrates and fats, while other foods, particularly vegetables, are viewed as "safe." In an effort to rationalize their restrictions, patients may develop a sophisticated fund of nutritional knowledge. They may delude parents or other caretakers into believing that they are eating when in fact food may be hidden or vomited up. Patients may also become obsessed with preparing foods, which they then refuse to eat. Some patients may have episodes of binge eating with or without purging in addition to restriction. Patients with this form of anorexia nervosa are more likely to be depressed, suicidal, and self-harming.

Patients may persist in the belief that they are eating a lot when in fact they eat very little. Sensations of hunger and satiety are impaired, with the result that these two states become confused. Further, delayed gastric emptying due to developing malnutrition may contribute to the perception of fullness after consumption of only small amounts of food. Eventually the person may reject all or nearly all foods.

The "anorectic attitude" may be self-amplifying, in that starvation itself may lead to abnormal attitudes towards food. Semistarved persons who are otherwise in good health also develop an obsession with food, linger for hours over a meal, and may feel that once they start eating, they will not be able to stop. For persons with AN, the thought that they may not be able to stop may be a terrifying prospect, confirming their worst fears about their inability to control their appetite.

The types of food that a person with AN likes appear to be normal when ascertained by questionnaire; however, a dislike for high-fat and low-carbohydrate foods is revealed. Taste testing suggests that persons with AN have an abnormally high preference for highly sweet tastes, coupled with a dislike of fatty foods. In this phase, the person may use laxatives and enemas, in the belief that these procedures will prevent absorption of ingested food, and also because anorexics may judge themselves to be constipated since the severely reduced food intake leads to formation of smaller than normal amounts of feces. Laxatives and starvation-induced changes in gut motility lead to both constipation and complaints of abdominal pain. Patients may abuse diuretics in an attempt to lose weight, although their effect is confined to water weight loss.

Patients may participate in extreme physical activity, preferably carried out alone, although it may be expressed in organized group activities such as ballet or athletic performance. This physical hyperactivity is in direct contrast to the inactivity seen in starving subjects without AN.

Depression, anxiety, obsessional traits, perfectionism, and rigidity in thinking are all found in patients in Phase II of AN. The states are often associated with social isolation.

During Phase II, nutritional status may deteriorate steadily, and if untreated, patients may not enter the recovery phase, Phase III. Death may occur from cardiovascular collapse due to starvation and electrolyte imbalance, or due to too rapid refeeding, as well as suicide. As many as 5 percent of patients may die of AN in the acute phase, and 20 percent on long-term follow-up—the highest mortality rate for a psychiatric condition.

Phase III of this disease, which is attained only with difficulty, and in some cases not at all, is the acknowledgment by the patients that they have starved themselves, and need treatment, coupled with success at alleviating the signs and symptoms of the disease.

Management. The management of anorexia nervosa is complex, requiring a concerted effort on the part of the health care team, including physician, nurse, nutritionist, social worker, and psychologist, as well as the patient and his or her family. Because patients are capable of maintaining a state of denial, it is very difficult to engage the patient into the care process. Often the patient has to be in a state of collapse before intervention is even tolerated. Indications for hospitalization are weight loss below 40 percent of normal weight; orthostatic hypotension (low blood pressure when standing); electrolyte (sodium, potassium) imbalance; dehydration; hypoglycemia (low blood sugar); infection; and marked family disturbance.

Treatment involves refeeding and psychological rehabilitation. Refeeding is critical for all patients whose weight is 85 percent or less of that expected. Depending on the severity of the patient's malnutrition, feeding may occur in the hospital, in a clinic setting, or at home. The patient should be hospitalized well before collapse is imminent. Feeding may be oral, naso-gastric, or via intravenous lines. Oral feeding is preferred but some patients may only permit refeeding if it is through a naso-gastric tube, and thus beyond their control. Intravenous feedings may be required if cardiovascular collapse is imminent. No special diets are needed, although concentrated foods may be useful in attaining adequate caloric intakes, and vitamin and mineral supplements are required. Refeeding must be slow, and performed under close medical monitoring, lest the patient develop edema and increased circulating blood volume, which can lead to electrolyte imbalances, anemia, and cardiovascular collapse. Other fatal complications of rapid refeeding include acute stomach or large bowel dilatation. Treatment protocols may also include restriction of exercise, in order to prevent the patient from exercising away the calories. Some patients are adept at finding ways to increase physical activity in the face of exercise restriction, and some patients may become severely agitated when denied the right to exercise.

Psychological treatment varies by health care team and may combine individual, family, and group therapy. Drug therapy may be used, particularly selective serotonin reuptake inhibitors (SSRIs), especially in patients who have regained weight but still are depressed or have obsessive-compulsive symptoms.

The ideal of clinical improvement consists of a return to 90 percent of normal weight, the resumption or initiation of menses in women, normalization of eating patterns, as well as the development of a mature, self-confident outlook, with a normal body image. Few patients attain this ideal. However, the short-term prognosis with respect to weight gain, return of menses, and improvement in outlook is usually good, although the food obsession and inability to control appetite may persist for weeks to months after the patient has regained an adequate amount of weight.

Unfortunately, the long-term prognosis is not so favorable: On the average, about 40 percent of patients recover more or less completely, 27 percent have ongoing endocrine abnormalities or are mildly underweight, 29 percent have a serious recurrence of the disease within a four-year period, and up to 5 percent succeed in starving themselves to death. Those who are over twenty, have prolonged illness, are depressed, have a family history of mental disturbance, have poor family relationships, who use purgatives and diuretics and who follow binges with vomiting have the worst prognosis.

Bulimia Nervosa

People with bulimia nervosa (BN) have recurring irresistible urges to consume extremely large amounts of food at one sitting (binge). The binge leads to acute feelings of gastric distension, and to sharpening of the fear of becoming fat. To relieve both problems, patients may then proceed to self-induce vomiting or purging. Persons with this condition report a sense of "cleaning out" with vomiting and purging, which may positively reinforce these behaviors. Note that binging without purging comes under the rubric of Eating Disorders Not Otherwise Specified (EDNOS), according to the Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (DSM IV), and is described below.

Precipitants of a binge include hunger, being alone, feelings of anxiety, frustration, and worthlessness, and problems with a significant other.

Epidemiology. Like AN, BN primarily afflicts young females from food-rich backgrounds. Its prevalence is unknown because only the most severely affected come to health care. Estimates of the disorder vary from 2.5 to 20 percent of women and 1 to 5 percent of men from the ages of eighteen to twenty-one.

Etiology. The etiology of BN remains unknown. Causes may include a biological predisposition to obesity, depression, and metabolic disturbances (in particular neurohormonal abnormalities, such as abnormalities in the release of gut hormones after eating), coupled with a socially determined desire for thinness, and with bingeing and purging as a group activity, a phenomenon which is becoming increasingly common among women living together, for example in a sorority, or men as part of a team, for example wrestlers.

Families of BN patients have a high prevalence of disorders such as major depression, irritable bowel syndrome, obsessive-compulsive disorder, attention deficit disorder with hyperactivity, and migraine, all of which have been linked to abnormalities in the function of neurotransmitters (chemicals such as norepinephrine and serotonin responsible for sending messages from one nerve cell to the next) in the brain. Levels of monoamine oxidase (MAO, an enzyme responsible for degrading norepinephrine and serotonin) in the blood cell clotting fragments called platelets are lower than normal in a person with BN. Low activity of MAO has been associated with impulsiveness, intolerance of boredom and monotony, and sensation seeking, also commonly seen in bulimic individuals. SSRIs, specifically fluoxetine, which increase responsiveness to endogenous serotonin, are moderately effective in treatment of BN. Abnormalities in other hormones and neurotransmitters, including cholecystokinin (CKK), which is released in response to fat in the intestine and depresses appetite, neuropeptide YY, which is involved in activating appetite, and leptin, are under investigation.

Table 1

Physical signs and symptoms associated with anorexia nervosa and bulimia nervosa
	Anorexia nervosa	Bulimia nervosa
Body weight	Usually below normal	May be below normal, normal, or above normal
Skin and hair	Dry skin; lanugo (soft down-like hair overgrown on limbs, nape of neck, and cheeks); yellowing of skin (but not whites of eyes) due to excessive consumption of carrots and other carotene containing vegetables	Scratches on the dorsum of the hand due to rubbing of the hand against the upper teeth during self-induced vomiting
Teeth	Increased caries due to acid erosion, if patient vomits frequently	Carious due to acid erosion, if patient vomits frequently
Water and electrolytes	Low blood potassium, due to vomiting; low blood sodium due to use of laxatives	Low blood potassium due to frequent vomiting
Bones	Osteoporosis leading to irreversible vertebral collapse, due to lack of estrogen, and to reduced consumption and to malabsorption of minerals and fat soluble vitamins	Incidence of osteoporosis variable
Amenorrhea	Characteristic	Variable
Brain	Brain damage in long-term disease, which may be irreversible	Unknown
Gastro-intestinal tract	Slow gastric emptying and slow intestinal transit time, due to starvation	An enlarged stomach with stomach cramping, leading to digestive difficulties; esophageal irritation, due to regurgitation of stomach acid; dysmotility of the esophagus (poor coordination of esophageal movement); slow stomach emptying; injury to the nerves in the gut wall, leading to permanent loss of bowel reactivity; constipation and diarrhea.
Metabolic rate	Reduced	Mildly reduced
Body temperature	Reduced, with difficulty maintaining a steady body temperature in cold or warm conditions; an occasional patient has an elevated metabolic rate	Variable
Cardiovascular system	Hypotension (abnormally low blood pressure); bradycardia (slow heart rate); decreased heart size and cardiac output	Variable, depending on body weight; if body weight is low, the signs are similar to those seen in Anorexia nervosa.
Blood	Anemia and leukopenia (low white blood cell count) due to inadequate mineral intake and to starvation	Anemia, due to frequent small upper gastrointestinal tract bleeds, leading to iron loss
Causes of death	Cardiovascular collapse, suicide	Cardiovascular collapse, suicide

Development, diagnosis, and clinical manifestations. The phases of development of BN are far less clear than those of AN, though, as children, patients with this condition may have had pica (the consumption of nonfood items such as dirt or paint chips), and may have suffered through mealtimes in which there was a great deal of commotion and distress. Some bulimics have been severely abused physically, sexually, or both and may show signs and symptoms of post-traumatic stress disorder, including multiple personality disorder.

It is difficult to determine when bingeing becomes an overt pathological state. Binge episodes may vary from several times daily to once a month or less, and 20 percent of female college students are estimated to have participated at least once in a binge-purge episode.

A binge-purge episode starts with a craving for high-calorie food, usually those high in carbohydrates and fat but low in protein, particularly junk food, which does not have to be cooked. The food is obtained and consumed at one sitting. Thus, a patient may consume a box of cookies, a bag of doughnuts, and a half-gallon of ice cream in a single binge. The binge may then be followed by self-induced vomiting, and/or laxative use. Binges and purges most often occur in private, although there is an increase in group binge-purge episodes among young people who live in communal settings, for example in boarding school or in college. The frequency of episodes increases with increasing stress. Some patients may fast between episodes of bingeing, and may in fact have the binge-eating/ purging form of AN. Other patients may binge without purging.

In BN, eating patterns outside a binge-purge episode are usually characterized by a degree of restrained eating. Nevertheless, when bulimics perceive that they have "violated" the restraint, that is, eaten more than "allowed," they will eat more than a normal person in a test meal situation. Increased postmeal hunger is also experienced by individuals with BN. The restrained eating may therefore be the result of conscious attempts to compensate for the inability to feel satiety, and may be a mechanism for maintaining normal weight in the face of episodes of great hunger and craving. Patients have larger than normal stomachs, which results in both slower than normal stomach emptying and failure to sense fullness, due to excessive relaxation of the stomach, and lower than normal levels of the hormone cholecystokinin (CCK) after a meal. CCK is produced in the intestinal tract in response to fatty food, and signals to the brain that the person has eaten enough. As a result of these changes, the person may fail to be aware of satiety. It may be that once binge-purge episodes have begun, these anatomical and physiological changes will amplify the perceived need to binge, and the consequent need to purge.

In taste tests, persons with BN have a higher than normal preference for very sweet and very fatty foods. Normally, the more a person eats of a sweet food at a single sitting, the less pleasant it becomes. Bulimics may not experience this decrease in pleasantness, as a result of which they may be able to eat large amounts of highly sweet food.

The hypothalamus normally senses when blood glucose levels have risen following food ingestion, which also contributes to the feeling of satiety. Persons with BN appear to have mild insulin resistance, which may prevent their hypothalamus from sensing that rise in blood glucose levels.

Persons with BN are less likely than persons with AN to have a distorted body image, though persons with BN do express an overvaluation of thinness and a fear of becoming overweight. A person with BN may be depressed and agitated, but, unlike a person with AN, usually does not participate compulsively in physical activity.

The most striking complaints and physical and biochemical findings regarding BN are related to the frequent vomiting (Table 1). The ability to taste with the palate may be destroyed due to the stomach acid, although taste by the tongue is little affected. Whether these taste changes contribute to bingeing is unknown.

Management. Bulimia nervosa requires long-term, continuous, nonjudgmental psychological management, nutritional counseling, and rehabilitation, and may include medications, particularly SSRIs. Cognitive behavioral therapy approaches that redirect the person's attention away from food and eating, and which address the person's other psychological problems, are the most successful. Patients may have other conditions, such as drug abuse or personality disorders, which need to be addressed before the eating disorder. Both depressed and nondepressed patients with BN may benefit from medications such as SSRIs. These drugs may help with interpersonal functioning, mood, and anxiety symptoms.

Eating Disorder Not Otherwise Specified

Eating Disorder Not Otherwise Specified (EDNOS) is the term applied to conditions that have some characteristics of the classic eating disorders AN and BN, but which do not meet all the diagnostic criteria outlined in the DSM-IV. Multiple combinations of signs and symptoms are possible, as noted in Table 1. Persons who abuse weight-reduction medications and other regimens, and who are trying to lose large amounts of weight for reasons of beauty rather than health, as well as persons with binge-eating disorder, also fall under this rubric, as do people who use disordered eating behaviors in an attempt to correct the size of what they perceive as abnormally large (or abnormally small) body parts.

Binge-eating disorder is characterized by binges that are not followed by efforts to get rid of the extra calories. It is estimated that about 2 percent of the general population suffers from this condition, with a male to female ratio of 1 to 3, in contrast with frank bulimia nervosa, where the proportion is closer to 1 in 6. Because people who have this disorder do not vomit or purge, they are often obese; they compose about a third of the patients visiting weight reduction clinics. They also may have body image dissatisfaction, low self-esteem, and depression. Active psychotherapy can reduce binge frequency, but once therapy is discontinued, relapse rates are high, and weight lost due to the decrease in binge frequency is often readily regained. Approaches that emphasize self-acceptance, improvement of body image, and better overall health, rather than focusing on weight loss, appear to have the best long-term success rate. It is likely that similar approaches may be effective for people who abuse weight-loss regimens.

Diagnostic Criteria for Anorexia Nervosa (Diagnosis Number 307.1)

• A. Refusal to maintain body weight at or above a minimally normal weight for age and height (e.g., weight loss leading to maintenance of body weight less than 85 percent of that expected; or failure to make expected weight gain during period of growth, leading to body weight less than 85 percent of that expected).
• B. Intense fear of gaining weight or becoming fat, even though underweight.
• C. Disturbance in the way in which one's body weight or shape is experienced, undue influence of body weight or shape on self-evaluation, or denial of the seriousness of the current low body weight.
• D. In postmenarcheal females, amenorrhea, i.e., the absence of at least three consecutive menstrual cycles. (A woman is considered to have amenorrhea if her periods occur only following hormone, e.g., estrogen, administration.)

Specify type:

Restricting Type: during the current episode of anorexia nervosa, the person has not regularly engaged in binge-eating or purging behavior (i.e., self-induced vomiting or the misuse of laxatives, diuretics, or enemas).

Binge-Eating/Purging Type: during the current episode of anorexia nervosa, the person has regularly engaged in binge-eating or purging behavior (i.e., self-induced vomiting or the misuse of laxatives, diuretics, or enemas).

SOURCE: American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, D.C.: American Psychiatric Association, 1994.

Diagnostic Criteria for Bulimia Nervosa (Diagnosis Number 307.51)

• A. Recurrent episodes of binge eating. An episode of binge eating is characterized by both of the following:
  1. eating, in a discrete period of time (e.g., within any 2-hour period) an amount of food that is definitely larger than most people would eat during a similar period of time and under similar circumstances
  2. a sense of lack of control over eating during the episode (e.g., a feeling that one cannot stop eating or control what or how much one is eating)
• B. Recurrent inappropriate compensatory behavior in order to prevent weight gain, such as self-induced vomiting; misuse of laxatives, diuretics, enemas, or other medications; fasting; or excessive exercise.
• C. The binge eating and inappropriate compensatory behaviors both occur, on average, at least twice a week for three months.
• D. Self-evaluation is unduly influenced by body shape and weight.
• E. The disturbance does not occur exclusively during episodes of anorexia nervosa.

Specify type:

Purging Type: during the current episode of bulimia nervosa, the person has regularly engaged in self-induced vomiting or the misuse of laxatives, diuretics, or enemas.

Non-Purging Types: during the current episode of bulimia nervosa, the person has used other inappropriate compensatory behaviors, such as fasting or excessive exercise, but has not regularly engaged in self-induced vomiting or the misuse of laxatives, diuretics, or enemas.

SOURCE: American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, D.C.: American Psychiatric Association, 1994.

Diagnostic Criteria for Eating Disorder Not Otherwise Specified (Diagnosis Number 307.50)

The Eating Disorder Not Otherwise Specified category is for disorders of eating that do not meet the criteria for any specific Eating Disorder. Examples include

1. For females, all of the criteria for anorexia nervosa are met except that the individual has regular menses.
2. All of the criteria for anorexia nervosa are met except that, despite significant weight loss, the individual's current weight is in the normal range.
3. All of the criteria for bulimia nervosa are met except that the binge eating and inappropriate compensatory mechanisms occur at a frequency of less than twice a week or for a duration of less than 3 months.
4. The regular use of inappropriate compensatory behavior by an individual of normal body weight after eating small amounts of food (e.g., self-induced vomiting after the consumption of two cookies).
5. Repeatedly chewing and spitting out, but not swallowing, large amounts of food.
6. Binge-eating disorder: recurrent episodes of binge eating in the absence of the regular use of inappropriate compensatory behaviors characteristic of bulimia nervosa.

SOURCE: American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, D.C.: American Psychiatric Association, 1994.

Bibliography

American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, D.C.: American Psychiatric Association, 1994.

American Psychiatric Association. Practice Guideline for theTreatment of Patients with Eating Disorders, 2d ed. Washington, D.C.: American Psychiatric Association, 2000.

Boskind-White, Marlene, and William C. White, Jr. Bulimia/Anorexia : The Binge/Purge Cycle and Self-Starvation, 3d ed. New York: Norton, 2000.

Gull, Sir William W. "Anorexia nervosa (apepsia hysterica, anorexia hysterica)." Transactions of the Clinical Society of London 7 (1874): 22.

Hobart Julie A., and Douglas R. Smucker. "The Female Athlete Triad." American Family Physician 61 (2000): 3357–3364, 3367.

—Virginia Utermohlen

A short name for anorexia nervosa.

absence of desire for food. In infants it is the failure to thrive. Anorexia nervosa is a feeding disorder, predominantly of females, that starts typically in adolescence and is associated with amenorrhea and regression of secondary sexual characteristics common in hypothalamic dysfunction.

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Lack or loss of appetite for food. Appetite is psychological, dependent on memory and associations, as compared with hunger, which is physiologically aroused by the body's need for food. Anorexia can be brought about by unattractive food, surroundings, or the presence of other animals. The existence of appetite in animals is assumed. For strictest accuracy the words aphagia, anophagia, etc. should be used but common usage includes anorexia, hyperorexia, etc. Called also inappetence.

(anōrek′sē-ə)
n

The partial or complete loss of appetite for food.

See words rhyming with "anorexia."

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Dansk (Danish)
n. - anoreksi

idioms:

• anorexia nervosa    nervøs spisevægring, anorektisk spiseforstyrrelse

Nederlands (Dutch)
anorexia

Français (French)
n. - anorexie

idioms:

• anorexia nervosa    anorexie mentale

Deutsch (German)
n. - Magersucht, Anorexie

idioms:

• anorexia nervosa    Anorexia nervosa, Magersucht

Ελληνική (Greek)
n. - (παθολ.) ανορεξία

idioms:

• anorexia nervosa    νευρική ανορεξία

Italiano (Italian)
anoressia

idioms:

• anorexia nervosa    anoressia nervosa

Português (Portuguese)
n. - anorexia (f) (Med.)

idioms:

• anorexia nervosa    anorexia nervosa (Med.)

Русский (Russian)
отсутствие аппетита

idioms:

• anorexia nervosa    патологическое отвращение к пище

Español (Spanish)
n. - anorexia

idioms:

• anorexia nervosa    anorexia nerviosa

Svenska (Swedish)
n. - anorexi

中文（简体）(Chinese (Simplified))
厌食, 食欲减退

idioms:

• anorexia nervosa    神经性厌食症

中文（繁體）(Chinese (Traditional))
n. - 厭食, 食欲減退

idioms:

• anorexia nervosa    神經性厭食症

한국어 (Korean)
n. - 식욕부진

日本語 (Japanese)
n. - 食欲不振

idioms:

• anorexia nervosa    神経性無食欲症

العربيه (Arabic)
‏(الاسم) فقدان الشهيه الى الطعام‏

עברית (Hebrew)
n. - ‮אובדן התיאבון למזון, פחד מהשמנה, אנורקסיה‬

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