An antimetabolite is any substance which competes with or inhibits the normal metabolic process, often by acting as an analogue of an essential metabolite.

Antimetabolites interfere with the production of DNA and keep cells from growing and multiplying. An example of an antimetabolite is 5-fluorouracil (5-FU).

5-bromouracil is a base analoge or antimetabolite. It substitutes thymine residue in DNA. After one cycle of replication it introduce other base and in this way it makes a point mutation.

the surgeon makes a tiny hole in the sclera as a passageway for aqueous humor. Some surgeons use an erbium YAG laser to create the hole. Most surgeons apply an antimetabolite drug during the procedure

aNAINST ANTIBIOTICS:

Inhibition of Cell Wall Synthesis (most common mechanism)

Inhibition of Protein Synthesis (Translation) (second largest class)

Alteration of Cell Membranes

Inhibition of Nucleic Acid Synthesis

Antimetabolite Activity