artificial selection

This Chihuahua mix and Great Dane show the wide range of dog breed sizes created using artificial selection.

Artificial selection (or selective breeding) describes intentional breeding for certain traits, or combination of traits. The term was utilized by Charles Darwin in contrast to natural selection, in which the differential reproduction of organisms with certain traits is attributed to improved survival or reproductive ability (“Darwinian fitness”). As opposed to artificial selection, in which humans favor specific traits, in natural selection the environment acts as a sieve through which only certain variations can pass.

The deliberate exploitation of artificial selection has become very common in experimental biology, as well as the discovery and invention of new drugs.

Artificial selection can also be unintentional; it is thought that domestication of crops by early humans was largely unintentional.^[1]

Historical development

Charles Darwin coined the term as an illustration of his proposed wider process of natural selection. Darwin noted that many domesticated animals and plants had special properties that were developed by intentional animal and plant breeding from individuals that showed desirable characteristics, and discouraging the breeding of individuals with less desirable characteristics.

Darwin used the term twice in the 1859 first edition of his work On the Origin of Species, in Chapter IV: Natural Selection, and in Chapter VI: Difficulties on Theory –

Slow though the process of selection may be, if feeble man can do much by his powers of artificial selection, I can see no limit to the amount of change, to the beauty and infinite complexity of the coadaptations between all organic beings, one with another and with their physical conditions of life, which may be effected in the long course of time by nature's power of selection.^[2] We are profoundly ignorant of the causes producing slight and unimportant variations; and we are immediately made conscious of this by reflecting on the differences in the breeds of our domesticated animals in different countries,—more especially in the less civilized countries where there has been but little artificial selection.^[3]

Contrast to natural selection

It should be emphasized that there is no real difference in the genetic processes underlying artificial and natural selection, and that the concept of artificial selection was used by Charles Darwin as an illustration of the wider process of natural selection. The selection process is termed "artificial" when human preferences or influences have a significant effect on the evolution of a particular population or species. Indeed, many evolutionary biologists view domestication as a type of natural selection and adaptive change that occurs as organisms are brought under the control of human beings.

Laboratory usage

The deliberate exploitation of selective power has become common in experimental biology, particularly in microbiology and genetics. In a ubiquitous laboratory technique in genetic engineering, genes are introduced into cells in cell culture, usually bacteria, on a small circular DNA molecule called a plasmid in a process called transfection. The gene of interest is accompanied on the plasmid by a reporter gene, or "selectable marker", which encodes a specific trait such as antibiotic resistance or ability to grow in high salt concentrations. The cells can then be cultured in an environment that would kill normal cells, but is hospitable to those that have taken up and expressed the genes on the plasmid. In this way expression of the reporter gene serves as a signal that the gene of interest is also being expressed in the cells.

Another technique used in drug development uses an iterative selective process called in vitro selection to evolve aptamers, or nucleic acid fragments capable of binding specific organic compounds with high binding affinity.

Studies in evolutionary physiology, behavioral genetics, and other areas of organismal biology have also made use of deliberate artificial selection, though longer generation times and greater difficulty in breeding can make such projects challenging in vertebrates.^{[4] [5] [6]}

References

1. ^ Artificial Selection PowerPoint, University of Wisconsin-Madison
2. ^ Darwin 1859, p. [1]
3. ^ Darwin 1859, pp. 197–198
4. ^ Swallow JG, Garland T, Jr. (2005). Selection experiments as a tool in evolutionary and comparative physiology: insights into complex traits—an introduction to the symposium. Integr Comp Biol, 45:387–390.PDF
5. ^ Garland T, Jr. (2003). Selection experiments: an under-utilized tool in biomechanics and organismal biology. Ch.3, Vertebrate Biomechanics and Evolution ed. Bels VL, Gasc JP, Casinos A. PDF
6. ^ Garland T, Jr., Rose MR, eds. (2009). Experimental Evolution: Concepts, Methods, and Applications of Selection Experiments.University of California Press, Berkeley, California. In press.

See also

• Animal breeding
• Experimental evolution
• Gene pool
• Genetic engineering
• Inbreeding
• Marker assisted selection
• Plant breeding
• Quantitative genetics
• Selective breeding
• Selection methods in plant breeding based on mode of reproduction
• Smart breeding