(immunology) An autoimmune disease in which antibodies initiate complement lysis of red blood cells.
| Sci-Tech Dictionary: autoimmune hemolytic anemia |
(immunology) An autoimmune disease in which antibodies initiate complement lysis of red blood cells.
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| Medical Dictionary: autoimmune hemolytic anemia |
Either of two forms of hemolytic anemia involving autoantibodies against red cell antigens; a cold-antibody type, caused by hemagglutinating cold antibody; and a warm-antibody type, due to serum autoantibodies that react with the patient's red blood cells, with antigenic specificity being chiefly in the Rh complex. Also called autoallergic hemolytic anemia.
| Wikipedia: Autoimmune hemolytic anemia |
| Autoimmune hemolytic anemia | |
|---|---|
| Classification and external resources | |
| ICD-10 | D59.0-D59.1 |
| ICD-9 | 283.0 |
| MeSH | D000744 |
Autoimmune hemolytic anemia (AIHA) is a type of hemolytic anemia where the body's immune system attacks its own red blood cells (RBCs), leading to their destruction (hemolysis).[1][2] Types of AIHA include Warm autoimmune hemolytic anemia, Cold agglutinin disease, and Paroxysmal cold hemoglobinuria.
Contents |
Although MeSH uses the term "autoimmune hemolytic anemia",[3] some sources prefer the term "immunohemolytic anemia" so that drug reactions can be included in this category.[4][5]
The National Cancer Institute considers "immunohemolytic anemia", "autoimmune hemolytic anemia", and "immune complex hemolytic anemia" to all be synonyms.[6]
Antibodies and associated complement system components become fixed onto the RBC surface. These antibodies can be detected with the direct antiglobulin test, also known as the direct Coombs test.
AIHA can also be induced by several drugs including methyldopa and fludarabine.
Haemolysis can be intravascular or extravascular.
Evidence for Haemolysis[7]
Increased red cell breakdown:
Increased red cell production:
Specific Investigations
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| AIHA | |
| immune-mediated | |
| autoimmune |
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