Balsalazide
Drug Info:
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Balsalazide
Brand names: Colazal®
Chemical formula:
- Drug Forms:
- Balsalazide capsules (below)
- Balsalazide Disodium Oral capsule
Balsalazide capsules
What are balsalazide capsules?
BALSALAZIDE (Colazal®) is an antiinflammatory agent. It reduces inflammation inside the bowel and pain associated with ulcerative colitis and helps to prevent recurring inflammation. Generic balsalazide capsules are not yet available.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
• kidney or liver disease
• an unusual or allergic reaction to balsalazide, aspirin, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding
How should I take this medicine?
Take balsalazide capsules by mouth. Follow the directions on the prescription label. Swallow the capsules whole with a drink of water. Take your doses at regular intervals. Do not take your medicine more often than directed.
Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.What drug(s) may interact with balsalazide?
Specific interactions between balsalazide and other drugs have not been studied.
Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
What should I watch for while taking balsalazide?
Tell your prescriber or health care professional if your symptoms do not start to improve after several days. There is usually an improvement in 3 to 21 days. You may need about 6 weeks of treatment to get good results. It is important that you go on taking your medicine and only stop taking it on your prescriber's advice.
What side effects may I notice from taking balsalazide?
Side effects that you should report to your prescriber or health care professional as soon as possible:
• chest pain
• difficulty breathing, wheezing
• fever, chills, sore throat
• skin rash or itching
• unusual bleeding or bruising
• unusual weakness or tiredness
• yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• diarrhea
• headache
• nausea, vomiting
• stomach pain or cramps
Where can I keep my medicine?
Keep out of the reach of children in a container that small children cannot open.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
Last updated: 7/1/2002
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
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Balsalazide
Wikipedia on Answers.com:
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Balsalazide
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| Systematic (IUPAC) name | |
| (E)-5-([4-(2-carboxyethylcarbamoyl)phenyl]diazenyl)-2-hydroxybenzoic acid | |
| Clinical data | |
| Trade names | Colazal |
| AHFS/Drugs.com | monograph |
| MedlinePlus | a699052 |
| Pregnancy cat. | B (US) |
| Legal status | POM (UK) |
| Pharmacokinetic data | |
| Bioavailability | <1% |
| Protein binding | ≥99% |
| Half-life | 12hr |
| Identifiers | |
| CAS number | 80573-04-2  |
| ATC code | A07EC04 |
| PubChem | CID 5362070 |
| DrugBank | DB01014 |
| ChemSpider | 10662422 |
| UNII | P80AL8J7ZP |
| ChEBI | CHEBI:267413 |
| ChEMBL | CHEMBL102265  |
| Chemical data | |
| Formula | C17H15N3O6 |
| Mol. mass | 357.318 g/mol |
| SMILES | eMolecules & PubChem |
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 (what is this?) (verify) |
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Balsalazide is an anti-inflammatory drug used in the treatment of inflammatory bowel disease. It is sold under the name "Colazal" in the US and "Colazide" in the UK. It is also sold in generic form in the US by several generic manufacturers.
It is usually administered as the disodium salt.
Balsalazide releases mesalazine, also known as 5-aminosalicylic acid, or 5-ASA,[1] in the large intestine. Its advantage over that drug in the treatment of ulcerative colitis is believed to be the delivery of the active agent past the small intestine to the large intestine, the active site of ulcerative colitis.
References
- ^ Kruis, W.; Schreiber, I.; Theuer; Brandes; Schütz; Howaldt; Krakamp; Hämling et al (2001). "Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses". Gut 49 (6): 783–789. doi:10.1136/gut.49.6.783. PMC 1728533. PMID 11709512. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1728533.
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