BF may refer to:
- BF (protein), initialism for B factor, a triggering protein of the alternative pathway of complement activation
- Battlefront, a contested armed frontier between opposing forces
- Boyfriend, term for a male partner
- Best friend, in internet slang
- Beaver Falls, Pennsylvania, a city in western Pennsylvania
- Bonners Ferry, Idaho, a town in Idaho, United States
- Bongo Frontier, a pickup truck built by Kia Motors
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