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No. Both products contain an antihistamine. This is a therapeutic duplication which may result in significant additive side effects.

Q: Can you take allegra with Phenylephrine and diphenhydramine?

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No. Both products contain an antihistamine. This is a therapeutic duplication which may result in significant additive side effects.

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My friend had taken 25 mg of Diphenhydramine, and 500mg of Methocarbamol, and didn't have any problems. They reported being real sleepy. Ask your Doctor, though. What works for others, may not work for you.

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Since Theraflu contains phenylephrine it says you should not take it with Benadryl because it contains acetaminophen and diphenhydramine and can cause a reaction.

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Phenylephrine is a vasoconstricting agent.

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Diphenhydramine

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