A city of northwest Colombia on the Bay of Cartagena, an inlet of the Caribbean Sea. Founded in 1533, Cartagena was once the richest port on the Spanish Main. Population: 871,000.

The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2007, 2000 by Houghton Mifflin Company. Updated in 2007. Published by Houghton Mifflin Company. All rights reserved.