A semisynthetic analogue of cephalosporin, C16H17N3O3S, that is administered orally and has a broad spectrum of antibiotic activity.
[Alteration of CEPHA(LOSPORIN) + alteration of (HY)DROXYL.]
cefadroxil
Dictionary:
cef·a·drox·il (sĕf'ə-drŏk'səl)  |
| 5min Related Video: cefadroxil |
| Dental Dictionary: cefadroxil |
n
trade names: Duricef, Ultracef; drug class: first generation cephalosporin; action: inhibits bacterial cell wall synthesis, rendering cell wall osmotically unstable; uses: eradication of gramnegative bacilli from the upper and lower respiratory tracts, and treatment of urinary tract and skin infections and otitis media.
| Drug Info: Cefadroxil |
Brand names: Duricef®
Chemical formula:
- Drug Forms:
- Cefadroxil Monohydrate Oral suspension (below)
- Cefadroxil Monohydrate Oral tablet
- Cefadroxil Monohydrate Oral capsule
- Cefadroxil Hemihydrate Oral suspension
- Cefadroxil Hemihydrate Oral tablet
- Español:
- Cefadroxilo Monohidrato, Suspensión oral
- Cefadroxilo Monohidrato, Tableta oral
- Cefadroxilo Monohidrato, Cápsula oral
- Hemihidrato de Cefadroxilo, Suspensión oral
- Hemihidrato de Cefadroxilo, Tableta oral
Cefadroxil Monohydrate Oral suspension
What is this medicine?
CEFADROXIL is a cephalosporin antibiotic. It is used to treat infections of the skin, respiratory tract, sinuses, ear, and urinary tract. It will not work for colds, flu, or other viral infections.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
• bleeding problems
• kidney disease
• stomach or intestine problems (especially colitis)
• an unusual or allergic reaction to cefadroxil, other cephalosporin antibiotics, penicillin, penicillamine, other foods, dyes or preservatives
• pregnant or trying to get pregnant
• breast-feeding
How should I use this medicine?
Take this medicine by mouth. Follow the directions on the prescription label. Shake well before using. Use a specially marked spoon or container to measure your medicine. Ask your pharmacist if you do not have one because household spoons are not accurate. You can take the medicine with or without food. If it upsets your stomach it may help to take it with food. Take your doses at regular intervals. Do not take your medicine more often than directed. Finish all the medicine you are prescribed even if you think your infection is better.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. Cefadroxil has been used in children as young as 1 month old.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
Do not take the missed dose. Take only the next dose according to your normal schedule. Do not take double or extra doses. Do not take this medicine for longer than it is prescribed.What may interact with this medicine?
• other antibiotics
• probenecid
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Tell your doctor or health care professional if your symptoms do not get better in a few days.
If you are diabetic you may get a false-positive result for sugar in your urine. Check with your doctor or health care professional before you change your diet or the dose of your diabetes medicine.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• breathing problems
• dizziness
• fever or chills
• redness, blistering, peeling or loosening of the skin, including inside the mouth
• seizures
• severe or watery diarrhea
• sore throat
• swollen joints
• trouble passing urine or change in the amount of urine
• unusually weak or tired
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
• diarrhea
• gas or heartburn
• nausea, vomiting
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
Keep out of the reach of children.
Store in a refrigerator between 2 and 8 degrees C (36 and 46 degrees F). Do not freeze. Throw away any unused medicine after 14 days.
Last updated: 7/1/2002
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
| Wikipedia: Cefadroxil |
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Cefadroxil
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| Systematic (IUPAC) name | |
| (6R,7R)-7-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | |
| Identifiers | |
| CAS number | |
| ATC code | J01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C16H17N3O5S |
| Mol. mass | 363.389 g/mol |
| SMILES | & |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | plasma protein |
| Metabolism | unknown |
| Half life | 1.5 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | Oral |
Cefadroxil is a broad-spectrum antibiotic effective in Gram-positive and Gram-negative bacterial infections. It is a bactericidal antibiotic. It is marked by pharco B international under the name of Curisafe.
Contents |
Brand name
1. Arocef (Eskayef Bangladesh Limited), Bangladesh 2. Zadro 500 , India, 3. Duricef, Pakistan
General use
Cefadroxil is a first-generation cephalosporin antibacterial drug that is the para-hydroxy derivative of cefalexin, and is used similarly in the treatment of mild to moderate susceptible infections such as the bacteria "Streptococcus pyogenes", otherwise known as strep throat.
Pharmacokinetics
Cefadroxil is almost completely absorbed from the gastrointestinal tract. After doses of 500 mg and 1 g by mouth, peak plasma concentrations of about 16 and 30 micrograms/mL respectively are obtained after 1.5 to 2 hours. Although peak concentrations are similar to those of cefalexin, plasma concentrations are more sustained. Dosage with food does not appear to affect the absorption of cefadroxil. About 20% of cefadroxil is reported to be bound to plasma proteins. The plasma half-life of cefadroxil is about 1.5 hours and is prolonged in patients with renal impairment.
Cefadroxil is widely distributed to body tissues and fluids. It crosses the placenta and appears in breast milk.
More than 90% of a dose of cefadroxil may be excreted unchanged in the urine within 24 hours by glomerular filtration and tubular secretion; peak urinary concentrations of 1.8 mg/mL have been reported after a dose of 500 mg. Cefadroxil is removed by haemodialysis.
Dosage
Cefadroxil is given by mouth, and doses are expressed in terms of the anhydrous substance; 1.04 g of cefadroxil monohydrate is equivalent to about 1 g of anhydrous cefadroxil.
Side effects
The most common side effects of Cefadroxil are diarrhea (which, less commonly, may be bloody), nausea, upset stomach, and vomiting. Other side effects include[1]:
- Rashes
- Hives
- Itching
- Red, swollen, or blistered skin
- Unusual bruising or bleeding
- Sore throat
- Difficulty breathing
- Tightness in the chest
- Swelling of the mouth, face, lips, or tongue
- Decreased urination
- Dark urine
- Vaginal itching, odor, or discharge
- Fever
- Chills
- Joint pain
- Seizures
- Cramps
- Unusual tiredness or weakness
- Yellowing of the skin or eyes
Dental use
Cefadroxil is used as an antibiotic prophylaxis before dental procedures.
(Always consider Amoxicillin plus Metronidazole as first line of treatment for dental procedures. In Case of penicillin allergy consider "Cefadroxil" for prophylaxis.)
Veterinary use
Can be used for treating infected wounds on animals. Usually in powder form mixed with water has a color and smell similar to Tang. Given orally to animals, amount dependent on their weight and severity of infection.
References
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
Learn More
 | Duricef (trademark) |
| Cephalosporins |
| Cefadroxil Monohydrate Oral suspension |
 | What is cefadroxil? Read answer... |
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 | Dictionary. The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2007, 2000 by Houghton Mifflin Company. Updated in 2007. Published by Houghton Mifflin Company. All rights reserved. Read more |
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| Dental Dictionary. Mosby's Dental Dictionary. Copyright © 2004 by Elsevier, Inc. All rights reserved. Read more |
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| Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved. Read more |
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| Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved. Read more |
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| Wikipedia. This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Cefadroxil". Read more |
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