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Cefuroxime

 
Drug Info: Cefuroxime
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Brand names: Alti™Ceftin®Kefurox®Zinacef®

Chemical formula:



Cefuroxime oral suspension

What is cefuroxime oral suspension?

CEFUROXIME (Ceftin®) is a cephalosporin antibiotic. It treats many kinds of infections including those of the skin (impetigo), respiratory tract (tonsillitis), sinuses, and ear. Generic cefuroxime oral suspension is not yet available.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
• bleeding problems
• kidney disease
• stomach or intestinal problems (especially colitis)
• other chronic illness
• an unusual or allergic reaction to cefuroxime, other cephalosporin antibiotics, penicillin, penicillamine, other foods, dyes or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I take this medicine?

Take cefuroxime oral suspension by mouth. Follow the directions on the prescription label. Shake well before using. Use a specially marked spoon or container to measure your medicine. Ask your pharmacist if you do not have one; household spoons are not always accurate. Cefuroxime works best if you take it with food. Do not take your medicine more often than directed. Finish the full course prescribed by your prescriber or health care professional even if you think your condition is better. Do not stop taking except on your prescriber's advice.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What drug(s) may interact with cefuroxime?

• other antibiotics
• probenecid
• water pills

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What should I watch for while taking cefuroxime?

Tell your prescriber or health care professional if your symptoms do not begin to improve in a few days.

If you are diabetic you may get a false-positive result for sugar in your urine. Check with your prescriber or health care professional before you change your diet or the dose of your diabetic medicine.

If you get severe or watery diarrhea, do not treat yourself. Call your prescriber or health care professional for advice.

What side effects may I notice from taking cefuroxime?

Side effects that you should report to your prescriber or health care professional as soon as possible:
• difficulty breathing, wheezing
• dizziness
• fever or chills, sore throat
• headache
• reduced amount of urine
• redness, blistering, peeling or loosening of the skin, including inside the mouth
• seizures (convulsions)
• severe or watery diarrhea
• skin rash, itching
• swollen joints
• unusual bleeding or bruising
• unusual weakness or tiredness

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• diarrhea
• gas or heartburn
• nausea, vomiting
• vaginal itching

Where can I keep my medicine?

Keep out of the reach of children.

Store the dry powder for oral suspension at between 2 and 30 degrees C (36 and 86 degrees F). After mixing store at room temperature or in the refrigerator, between 2 and 25 degrees C (36 and 77 degrees F). Keep container tightly closed. Throw away any unused medicine after 10 days.

Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

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Veterinary Dictionary: cefuroxime
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Home > Library > Animal Life > Veterinary Dictionary

A second generation cephalosporin antibiotic.

WordNet: cefuroxime
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Home > Library > Literature & Language > WordNet
Note: click on a word meaning below to see its connections and related words.

The noun has one meaning:

Meaning #1: a cephalosporin that can be given parenterally (trade name Zinacef) or orally by tablets (trade name Ceftin); indicated for infections of the lungs or throat or ears or urinary tract or meninges
  Synonyms: Ceftin, Zinacef

Wikipedia: Cefuroxime
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Home > Library > Miscellaneous > Wikipedia
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Please help improve this article by adding reliable references. Unsourced material may be challenged and removed. (July 2007)
Cefuroxime
Systematic (IUPAC) name
(6R,7R)-3-{[(aminocarbonyl)oxy]methyl}-7-{[(2E)-2-(2-furyl)-2-(methoxyimino) acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Identifiers
CAS number 55268-75-2
ATC code J01DC02 QJ51DA06
PubChem 5361202
DrugBank APRD00285
ChemSpider 4514699
Chemical data
Formula C16H16N4O8S 
Mol. mass 424.386 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability 37% on empty stomach, up to 52% if taken after food
Metabolism axetil moiety is metabolized to acetaldehyde and acetic acid
Half life 80 minutes
Excretion Urine 66-100% Unchanged
Therapeutic considerations
Pregnancy cat.

Not known to be harmful (BNF)
Legal status

Prescription Only Medicine(UK/USA)
Routes oral, intramuscular, intravenous
 Yes check.svgY(what is this?)  (verify)

Cefuroxime is a second-generation cephalosporin antibiotic that has been widely available in the USA as Ceftin since 1977. GlaxoSmithKline sells the antibiotic in the United Kingdom (and other countries, such as Australia, Turkey, Israel, Bangladesh, Thailand and Poland) under the name Zinnat.[1]

Contents

Indications

As for the other cephalosporins, although as a second-generation it is less susceptible to Beta-lactamase and so may have greater activity against Haemophilus influenzae, Neisseria gonorrhoeae and Lyme disease.

Side effects

Cefuroxime is generally well tolerated and side effects are usually transient. Cefuroxime, if ingested with food, is both better absorbed and less likely to cause its most common side effects of diarrhea, nausea, vomiting, headaches/migraines, dizziness and abdominal pain.

Although there is a widely quoted cross-allergy risk of 10% between cephalosporins and penicillin, recent assessments have shown no increased risk for cross-allergy for cefuroxime and several other 2nd generation or later cephalosporins.[2]

Trade names

  • Altacef (Glenmark)
  • Axet 500mg tablets (Xeno Pharmaceuticals), Philippines
  • Biofuroksym (Bioton S.A.), Poland[3]
  • Cefteja (Quadra)
  • Ceftin (GlaxoSmithKline), United States and Canada
  • Ceftum (GlaxoSmithKline), India
  • Cefutil (Square Pharmaceuticals Ltd.), Bangladesh
  • Ceroxime 250mg and 500mg (Asiatic Laboratories Ltd.), Bangladesh
  • Cetil (Lupin)
  • Daroxime (Jordan)
  • Ecocef 750mg IV (Xeno Pharmaceuticals), Philippines
  • Famicef (The ACME Laboratories Ltd), Bangladesh
  • Forcef (Aristo), India
  • Haginat (DHG Pharma), Vietnam[4]
  • Kefstar (Wockhardt)
  • Kilmax (Eskayef Bangladesh Limited), Bangladesh
  • Maxil (Hikma Pharmaceutica), Portugal
  • Oxime 750mg IV (Allied Pharmaceutical Mktg Corp), Philippines[5]
  • Panaxim 750 and 500mg, (Panpharma-Meinz), Philippines
  • Secomax 250 and 500mg, (General Pharma), Bangladesh
  • Shincef, Philippines
  • Staxim (Delta Pharma Limited), Bangladesh[6]
  • U-cef, (Advanced Pharmaceutical Industries Co. Ltd), Jordan
  • Xylid (Pharmaniaga), Malaysia
  • Zamur (Mepha)
  • Zefu (FDC LTD), India
  • Zinacef (Glaxo Wellcome), China, Israel, United Kingdom
  • Zinadol (GlaxoSmithKline), Greece
  • Zinex (Birzeit Pharmaceutical Company), Palestine
  • Zinnat (GlaxoSmithKline), Belgium, Brazil, Malta, Israel, Hungary, Bulgaria
  • Zinoximor, Saudi Arabia
  • Zocef, (Alkem Laboratories), Malaysia

References

  1. ^ Zinnat entry on the Glaxo Smith Kline website.
  2. ^ Pichichero ME (2006). "Cephalosporins can be prescribed safely for penicillin-allergic patients" (PDF). The Journal of family practice 55 (2): 106–12. PMID 16451776. http://www.jfponline.com/pdf%2F5502%2F5502JFP_AppliedEvidence1.pdf. 
  3. ^ Jędrzejczyk, Tadeusz. "Internetowa Encyklopedia Leków". leki.med.pl. http://www.leki.med.pl/lek.phtml?id=428&idnlek=2682&menu=4. Retrieved 2007-03-03. 
  4. ^ Drugs.com: Haginat
  5. ^ Allied Pharmaceutical Marketing Corporation
  6. ^ Delta Pharma Limited
v • d • e
Antibacterials: cell envelope antibiotics (J01C-J01D)
Internal to membrane/
(inhibit peptidoglycan subunit
synthesis and transport)
NAM synthesis inhibition (Fosfomycin) · DADAL/AR inhibitors (Cycloserine) · bactoprenol inhibitors (Bacitracin)
Glycopeptide/
(inhibit PG chain elongation)
β-lactams/
(inhibit cross-links
with PBP)
Combinations
Other
#WHO-EM. ‡Withdrawn from market. CLINICAL TRIALS: †Phase III. §Never to phase III

This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)

 
 

 

Copyrights:

Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved.  Read more
Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.  Read more
WordNet. WordNet 1.7.1 Copyright © 2001 by Princeton University. All rights reserved.  Read more
Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Cefuroxime".  Read more