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cerivastatin

 
Dictionary: ce·riv·a·stat·in   (sə-rĭv'ə-stăt'n) pronunciation

n.
A statin, C 26H33FNO5Na, that blocks the body's synthesis of cholesterol and is administered especially to individuals at risk for heart disease.

[ceri-, of unknown origin + -vastatin, statin suff.; see pravastatin.]


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Drug Info: Cerivastatin
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Brand names: Baycol™

Chemical formula:



Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

WordNet: cerivastatin
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Note: click on a word meaning below to see its connections and related words.

The noun has one meaning:

Meaning #1: an oral drug (trade name Baycol) to reduce blood cholesterol levels
  Synonym: Baycol


Wikipedia: Cerivastatin
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Cerivastatin
Systematic (IUPAC) name
(3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(propan-2-yl)pyridin-3-yl]-3,5-dihydroxyhept-6-enoic acid
Identifiers
CAS number 145599-86-6
ATC code C10AA06
PubChem 446156
DrugBank APRD00102
Chemical data
Formula C26H34FNO5 
Mol. mass 459.55 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 2–3 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status

Withdrawn from market

Routes  ?


Cerivastatin (Baycol, Lipobay) is a synthetic member of the class of statins used to lower cholesterol and prevent cardiovascular disease. It was marketed by the pharmaceutical company Bayer A.G. in the late 1990s, competing with Pfizer's highly successful atorvastatin (Lipitor). Cerivastatin was voluntarily withdrawn from the market worldwide in 2001, due to reports of fatal rhabdomyolysis.

During post-marketing surveillance, 52 deaths were reported in patients using cerivastatin, mainly from rhabdomyolysis and its resultant renal failure.[1] Risks were higher in patients using fibrates, mainly gemfibrozil (Lopid), and in patients using the highest (0.8 mg/day) dose of cerivastatin. Bayer A.G. added contraindication about the concomitant use of cerivastatin and gemfibrozil to the package 18 months after the drug interaction was found.[2] Frequency of deadly incidents of rhabdomyolysis with cerivastatin was 16 to 80 times higher than with other statins.[3] Another 385 nonfatal cases of rhabdomyolysis were reported. This put the risk of this (rare) complication at 5-10 times that of the other statins. Cerivastatin also induced myopathy in a dose-dependent manner when administrated as monotherapy, but that was revealed only after producer of cerivastatin was sued and unpublished company documents were opened.[4]

References

  1. ^ Furberg CD, Pitt B. Withdrawal of cerivastatin from the world market. Curr Control Trials Cardiovasc Med 2001;2:205-207. PMID 11806796.
  2. ^ Psaty BM, Furberg CD, Ray WA, Weiss NS (2004). "Potential for conflict of interest in the evaluation of suspected adverse drug reactions: use of cerivastatin and risk of rhabdomyolysis". JAMA 292 (21): 2622–31. doi:10.1001/jama.292.21.2622. PMID 15572720. 
  3. ^ Zeitlinger M, Müller M (2003). "[Clinico-pharmacologic explanation models of cerivastatin associated rhabdomyolysis]" (in German). Wien Med Wochenschr 153 (11-12): 250–4. doi:10.1046/j.1563-258X.2003.03029.x. PMID 12879633. 
  4. ^ Saito M, Hirata-Koizumi M, Miyake S, Hasegawa R (2005). "[Withdrawal of cerivastatin revealed a flaw of post-marketing surveillance system in the United States]" (in Japanese). Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku (123): 41–5. PMID 16541751. 

Further reading


 
 
Learn More
Baycol (trademark)
Cholesterol-Reducing Drugs
Telithromycin Oral tablet

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Dictionary. The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2007, 2000 by Houghton Mifflin Company. Updated in 2009. Published by Houghton Mifflin Company. All rights reserved.  Read more
Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved.  Read more
WordNet. WordNet 1.7.1 Copyright © 2001 by Princeton University. All rights reserved.  Read more
Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Cerivastatin" Read more