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Charles Richet

 
Scientist: Charles Robert Richet

French physiologist (1850–1935)

Richet, the son of a distinguished Parisian surgeon, studied medicine at the University of Paris. After graduation in 1877 he worked at the Collège de France before he returned to the University of Paris where he served as professor of physiology from 1887 until his retirement in 1927.

Richet worked on a wide variety of problems, which ranged from heat regulation in mammals to the unsuccessful development of an anti-TB serum. His most important work began, however, with his investigation of how dogs react to the poison of a sea anemone. He found that he could induce a most violent reaction in dogs that had survived an original injection without any distress. If 22 days later he gave them a second injection of the same amount then they immediately became extremely ill and died in 25 minutes. Richet had discovered the important reaction of anaphylaxis, a term he coined in 1902 to mean the opposite of phylaxis or protection.

By 1903 he was able to show that the same effect could be produced by any protein whether toxic or not as long as there was a crucial interval of three to four weeks between injections. His work was to have profound implications for the newly emerging science of immunology and gained for Richet the 1913 Nobel Prize for physiology or medicine.

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Biography: Charles Robert Richet
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The French physiologist Charles Robert Richet (1850-1935) was awarded the Nobel Prize in Physiology or Medicine for his discovery of the phenomenon of anaphylaxis.

Charles Richet, the son of Alfred Richet, a professor in the University of Paris, was born in Paris on Aug. 25, 1850. He studied medicine in Paris and intended to become a surgeon, but he soon abandoned surgery for physiology. He graduated at Paris as a doctor of medicine in 1869 and as a doctor of science in 1878. He became a lecturer in physiology in 1879 and in 1887 professor of physiology in the Faculty of Medicine at Paris.

Discovery of Anaphylaxis

In 1890 the phenomenon of antitoxic immunity was discovered, and in 1891 diphtheria antitoxin was first used in treating diphtheria. It was soon found that the guinea pigs used for testing diphtheria antitoxin became acutely ill if long intervals separated the test injections. About 1900, while cruising in tropical waters, Richet studied the poison of the tropical jellyfish, the Portuguese man-of-war. Working with Paul Portier, he found that injection of a glycerol solution of the poison produced the symptoms of poisoning by the jellyfish. On their return to France they studied the toxins of local jellyfish. They determined the minimum dose that was fatal for dogs several days after its injection. Smaller doses than this produced only transient effects. But if a dog that had been injected with a small dose received a similar small dose after an interval of several weeks, a violent reaction killed the dog.

By 1902 Richet had studied this phenomenon in different animals. Reactions produced by the injection of antitoxins or minute doses of toxins had already been called prophylactic, or protective. Richet realized that in this new phenomenon the first dose sensitized the animal, so that the second injection produced a violent reaction. The first dose was the opposite of prophylactic, and he therefore called the phenomenon anaphylaxis. He showed clearly that the first injection of an animal toxin sensitized the test animal to even a very small second injection, and that, with very small doses, the violent symptoms following the second injection were out of all proportion to the mild symptoms following the first. He also established that, to produce the violent reaction, there must be an interval of several weeks between the injections.

In 1903 Nicolas Maurice Arthus of Lausanne described the Arthus phenomenon. If a rabbit was injected subcutaneously with repeated doses of horse serum, no effect was produced by the subsequent injections at first, but as the interval from the first injection lengthened, the injection site became swollen, hardened, and ulcerous. In 1905 Richard Otto showed that it was not the toxin in the "diphtheria antitoxin" (at that time a mixture of toxin and antitoxin was used) that produced serious effects in guinea pigs injected with repeated small doses at long intervals, but the horse serum in which the toxin was contained. Further, the reaction depended not upon the dose but upon the time interval. It was soon shown that a guinea pig injected with horse serum showed no hypersensitivity to the serum of other animals, and also that specific reactions occurred after the injection of milk, egg, or muscle extract. It was thus conclusively demonstrated that Richet's anaphylaxis was due to the injection of any protein, whether or not it was toxic on the first injection.

In 1907 Richet showed that, if the serum of an anaphylactic dog was injected into a normal dog, the latter became anaphylactic. The anaphylactic state could therefore be passively transmitted, and it was an antigen-antibody reaction. He continued to study anaphylactic phenomena, and for his work he was awarded the Nobel Prize in 1913. Anaphylaxis is closely associated with serum sickness and allergy, and later investigations of allergic diseases stem from Richet.

Richet wrote numerous works on physiology and edited two journals. He retired from his chair in 1927 and died in Paris on Dec. 4, 1935.

Further Reading

There is a biography of Richet in Nobel Lectures, Physiology or Medicine, 1901-1921 (1967), which also includes his Nobel Lecture. For his work in relation to the immunology of the period see C. Singer and E.A. Underwood, A Short History of Medicine (1962), and W. Bulloch, The History of Bacteriology (1938).

 
Columbia Encyclopedia: Charles Robert Richet
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Richet, Charles Robert (shärl rōbĕr' rēshā'), 1850-1935, French physiologist. From 1887 to 1927 he was professor at the Univ. of Paris. His special study was anaphylaxis, a term he used to describe a phenomenon noted earlier by Theobald Smith, i.e., a hyper-sensitive reaction (akin to allergy) to injections of foreign proteins, e.g., serums. For his work on anaphylaxis he received the 1913 Nobel Prize in Physiology or Medicine. He also worked on serum therapy, the nervous system, and animal heat and was interested in psychical research. Richet discovered that hydrochloric acid is the base of gastric juice.
(1850-1935)

Pioneer psychical researcher, honored professor of physiology at the Faculty of Medicine in Paris, and winner of the 1913 Nobel Prize in Physiology and Medicine. He was also the honorary president of La Societé Universelle d'études Psychiques, president of the Institut Métapsychique Internationale, and president of the Society for Psychical Research, London(1905). Richet was born on August 26, 1850, and educated at the University of Paris. He had an initial personal experience in lucidity (paranormal knowledge) in 1872. He confessed that although it had tremendous effect on him, he lacked the requisite intellectual courage to draw conclusions. In 1875, while yet a student, he demonstrated that the hypnotic state was a purely physiological phenomenon which had nothing to do with "magnetic fluids." "Following my article," he wrote of the result, "many experiments were widely made, and animal magnetism ceased to be an occult science."

A few years later, he published his studies in multiple personality. He sat with various mediums, including William Eglinton and Elizabeth d'Esperance, and in 1886-87 conducted many experiments in cryptesthesia with four subjects— Alice, Claire, Eugenie, and Leontine. Some were in a hypnotic, some in a waking state. They reproduced drawings enclosed in sealed envelopes. As a result of these experiments Richet formulated the theory of cryptesthesia in these words: "In certain persons, at certain times, there exists a faculty of cognition which has no relation to our normal means of knowledge."

He founded with Dr. Dariex the Annales des Sciences Psychiques in 1890, and two years later he took part in the investigation conducted by the Milan Commission with the medium Eusapia Palladino. The report admitted the reality of puzzling phenomena, expressing also the conviction that the results obtained in light, and many of those obtained in darkness, could not have been produced by trickery of any kind.

Richet did not sign the report and in his notes on it in the Annales des Sciences Psychiques carefully stated his conclusions as follows: "Absurd and unsatisfactory though they were, it seems to me very difficult to attribute the phenomena produced to deception, conscious or unconscious, or to a series of deceptions. Nevertheless, conclusive and indisputable proof that there was no fraud on Eusapia's part, or illusion on our part, is wanting: we must therefore renew our efforts to obtain such proof."

He became convinced of the reality of materialization phenomena by his experiments with the medium Marthe Béraud (better known as Eva C.) at the Villa Carmen, Algiers, in General Noel's house. His report, published in the Annales des Sciences Psychiques (April 1906) aroused wide attention. He confirmed his experiments in later sittings at the house of Juliette Bisson and at the Institut Métapsychique of which, after the resignation of Professor Santoliquido, he was elected president. He was unable to detect Eva C.'s fraud which was conclusively revealed only in the 1950s.

He conducted experiments with a number of different mediums including Franek Kluski, Jan Guzyk, and Stephen Ossowiecki, both in Paris and Warsaw.

His book Traité de Métapsychique (1922; translated as Thirty Years of Psychical Research, 1923) summed up the experiences of a lifetime. The book was dedicated to Sir William Crookes and F. W. H. Myers. It became a sign of repentance for his earlier skepticism. He stated in his work: "The idolatry of current ideas was so dominant at that time that no pains were taken either to verify or to refute Crookes' statements. Men were content to ridicule them, and I avow with shame that I was among the wilfully blind. Instead of admiring the heroism of a recognized man of science who dared then, in 1872, to say that there really are phantoms that can be photographed and whose heart beats can be heard, I laughed."

He accepted cryptesthesia, telekinesis, ectoplasm, materializations, and premonitions as abundantly proved. On the other hand, he considered doubtful apports, levitations, and the phenomena of the double, which he had no opportunity to examine thoroughly. He was most emphatic in stating: "The fact that intelligent forces are projected from an organism that can act mechanically, can move objects and make sounds, is a phenomenon as certainly established as any fact in physics." As if to leave a loophole for more definite proofs on psychic photography, direct writing, apports, psychic music, and luminous phenomena he added, somewhat naively: "No one would have thought of simulating them if they had never really occurred. I do not hesitate to think them fairly probable, but they are not proven."

His struggle with the problem of survival was very interesting. He stated: "I admit that there are some very puzzling cases that tend to make one admit the survival of human personality—the cases of Leonora E. Piper 's George Pelham, of Raymond Lodge and some others."

His basis for disbelief in survival was twofold: first, the human mind has mysterious faculties of cognition; second these mysterious cognitions have an invincible tendency to group themselves around a new personality. He explained: "The doctrine of survival seems to me to involve so many impossibilities, while that of an intensive cryptesthesia is (relatively) so easy to admit that I do not hesitate at all. I go so far as to claim—at the risk of being confounded by some new and unforeseen discovery—that subjective metapsychics will always be radically incapable of proving survival. Even if a new case even more astounding than that of George Pelham were to appear, I should prefer to suppose an extreme perfection of transcendental cognitions giving a great multiplicity of notions grouping themselves round the imaginary centre of a factitious personality, than to suppose that this centre is a real personality—the surviving soul, the will and consciousness of a self that has disappeared, a self which depended on a brain now reduced to dust….

"But except in a few rare cases, the inconsistency between the past and the present mentality is so great that in the immense majority of spiritist experiences it is impossible to admit survival, even as a very tentative hypothesis. I could more easily admit a non-human intelligence, distinct from both medium and discarnate, than the mental survival of the latter." Treating of the so-called death bed meeting cases he stated: "Among all the facts adduced to prove survival, these even seem to me to be the most disquieting."

He did not accept the facts of materialization as proof of survival.

"The case of George Pelham, though there was no materialization, is vastly more evidential for survival than all the materializations yet known. I do not even see how decisive proof could be given. Even if (which is not the case) a form identical with that of a deceased person could be photographed I should not understand how an individual two hundred years dead, whose body has become a skeleton, could live again with this vanished body any more than with any other material form."

He called the phenomena of materialization absurd, yet true, and explained: "Spiritualists have blamed me for using this word 'absurd'; and have not been able to understand that to admit the reality of these phenomena was to me an actual pain; but to ask a physiologist, a physicist, or a chemist to admit that a form that has a circulation of blood, warmth, and muscles, that exhales carbonic acid, has weight, speaks, and thinks, can issue from a human body is to ask of him an intellectual effort that is really painful."

In concluding his weighty Thirty Years of Psychical Research, he was assailed by doubts: "Truth to tell—and one must be as cautious in denial as in assertion—some facts tend to make us believe strongly in the survival of vanished personalities. Why should mediums, even when they have read no spiritualist books, and are unacquainted with spiritualist doctrines, proceed at once to personify some deceased person or other? Why does the new personality affirm itself so persistently, so energetically, and sometimes with so much verisimilitude? Why does it separate itself so sharply from the personality of the medium? All the words of powerful mediums are pregnant, so to say, with the theory of survival? These are semblances, perhaps, but why should the semblances be there?" Then, again, as if repenting his doubts, he explained: "Mysterious beings, angels or demons, existences devoid of form, or spirits, which now and then seek to intervene in our lives, who can by means, entirely unknown, mould matter at will, who direct some of our thoughts and participate in some of our destinies, and who, to make themselves known (which they could not otherwise do) assume the bodily and psychological aspect of vanished human personalities—all this is a simple manner of expressing and understanding the greater part of the metapsychic phenomena."

His next book, Notre Sixième Sens (1927; translated as Our Sixth Sense, 1929), was a courageous attempt to grapple with the problem of cryptesthesia. He conceived it physiologically as a new sixth sense which is sensitive to what he called the vibrations of reality. It is a sweeping theory that, in its implications, is nearly as far-reaching as the spirit theory.

In La Grande Espérance (1933), following an important monograph, L'Avenir et la Premonition (1931), he himself admitted that this vibratory theory is far from being sufficient for "there are cases in which á la rigeur one could suppose the intervention of a foreign intelligence."

These were the cases of veridical hallucinations. Even there he would have preferred to fall back on the vibratory explanation but for the puzzle of collective veridical hallucinations in which "one is almost compelled to admit the objective reality of the phantom." That admission did not allow him to doubt that "in cases of simple veridical hallucinations there is an objective reality as well." Pursuing this line of reasoning, he stated: "It appears that in certain cases phantoms are also inhabiting a house. I hesitate to write this down. It is so extraordinary that my pen almost refuses to write but just the same it is true."

Still, after having analyzed the purely psychological phenomena, if the choice was between the spirit hypothesis and a prodigious lucidity he would lean towards the second. For that explained all cases, whereas the former, although it is the better one in a small number of cases, was inadmissible in many others.

The grand hope of humanity lay in psychical research, in that immense incertitude which we feel in face of its extraordinary, truly absurd phenomena.

"The more I reflect and weigh in my mind these materializations, hauntings, marvelous lucidity, apports, xenoglossie, apparitions and, above all, premonitions, the more I am persuaded that we know absolutely nothing of the universe which surrounds us. We live in a sort of dream and have not yet understood anything of the agitations and tumults of this dream.

"Everything came down to this: "Either the human intelligence is capable of working miracles. I call miracles the phantoms, ectoplasm, lucidity, premonitions. Or assisting in our doings, controlling our thoughts, writing by our hand, or speaking by our voice there are, inter-blending with our life, mysterious, invisible entities, angels or demons, perhaps the souls of the dead, as the spiritualists are convinced. Death would not be death but the entrance into a new life. In each case we hurl ourselves against monstrous improbabilities (invraisemblances), we float in the inhabitual, the miraculous, the prodigious."

Richet died December 3, 1935.

Sources:

Berger, Arthur S., and Joyce Berger. The Encyclopedia of Parapsychology and Psychical Research. New York: Paragon House, 1991.

Gauld, Alan. The Founders of Psychical Research. New York: Schrocken Books, 1968.

Jules-Bois, A. H. "Charles Richet: Father of Metaphysics." Journal of the American Society for Psychical Research 30(1936).

Richet, Charles. Notre Sixième Sens. N.p., 1927. English ed. as Our Sixth Sense. N.p., 1929.

——. Traité de Métapsychique. N.p., 1922. English ed. as Thirty Years of Psychical Research. New York: Macmillan, 1923.

Wikipedia: Charles Richet
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Charles Richet

Born August 25, 1850(1850-08-25)
Died December 4, 1935 (aged 85)
Notable awards Nobel Prize in Physiology or Medicine (1913)

Charles Robert Richet (August 25, 1850December 4, 1935) was a French physiologist who initially investigated a variety of subjects such as neurochemistry, digestion, thermoregulation in homeothermic animals, and breathing.

He also devoted many years to the study of spiritualist phenomena.

Contents

Life

In 1887 Richet was named professor of physiology at the Collège de France, and in 1898 he became a member of the Académie de Médecine. It was, however, his work on anaphylaxis (his term for a sensitized individual's sometimes lethal reaction to a second, small-dose injection of an antigen) that in 1913 won him the Nobel Prize for Physiology or Medicine. This research helped elucidate hay fever, asthma and other allergic reactions to foreign substances and explained some previously not understood cases of intoxication and sudden death. In 1914 he became a member of the Académie des Sciences.

Richet was a man of many interests, and his works included books about history, sociology, philosophy, psychology, as well as theatre plays and poetry. He was a pioneer in aviation.

He also had a deep interest in extrasensory perception and hypnosis. In 1884 Alexander Aksakov interested him in the medium Eusapia Palladino. In 1891 Richet founded the Annales des sciences psychiques. He kept in touch with renowned occultists and spiritists of his time such as Albert von Schrenck-Notzing, Frederic William Henry Myers and Gabriel Delanne.

In 1905 Richet was named president of the Society for Psychical Research in the United Kingdom, and coined the terms "ectoplasm" and "metapsychics." He experimented with Marthe Béraud, Elisabette D'Espérance, William Eglinton and Stefan Ossowiecki. In 1919 he became honorary president of the Institut Métapsychique International in Paris, and, in 1929, full-time president.

Works

Richet's works on parascientific subjects, which dominated his late years, include Traité de Métapsychique (Treatise on Metapsychics, 1922), Notre Sixième Sens (Our Sixth Sense, 1928), L'Avenir et la Prémonition (The Future and Premonition, 1931) and La grande espérance (The Great Hope, 1933).

See also

External links


 
 
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