Reidar Sognnaes has written:

'Chemistry and prevention of dental caries'

The two factors that make biofilm in an intravenous line especially dangerous to the patient is infection and the difficulty of treatment. While the microorganisms are within the biofilm, they cannot be eradicated with antibiotics. However, if the biofilm were to detach from the IV line, the access to the circulatory system would potentially cause a massive infection.

Longevity.

Sterile or dry conditions

Biofilm forms when bacteria sticks to surfaces in moist environments by excreting a slimy substance. Examples of this would be the slippery rocks on the bottom of a stream or plaque on teeth.