Scleroderma

CREST syndrome

It affects the connective tissue

CREST syndrome is actually a collection of symptoms, not one or two that stand out. Signs can include exhaustion, weakness, difficulty breathing and dizziness.

CREST syndrome is a particular form of a condition called scleroderma. CREST actually stands for the cardinal signs and symptoms associated with the condition:

* Calcinosis (calcium deposits in the hands, particularly)

* Raynaud's phenomenon

* Esophageal dysmotility (difficulty/pain swallowing)

* Sclerodactly (tightness of skin around the fingers and hands)

* Telangiectasias (also called spider veins)

A very nice write up of the condition is available from eMedicine; see the related links section of this answer.