A drug, C23H14Na2O11, usually administered by inhalation and used to prevent certain allergic attacks, especially those associated with asthma or hay fever.
[Alteration of chromonyl, one of its constituents (CHROM(O)– + –ON(E) + –YL) + SODIUM.]
|
Results for cromolyn sodium
|
On this page:
|
trade names: Intal, Nasalcrom, Rynacrom; drug class: antiasthmatic; action: stabilizes the membrane of the sensitized mast cell, preventing release of chemical mediators; uses: allergic rhinitis, severe perennial bronchial asthma, exercise-induced broncho-spasm.
Brand names: Crolom®, Gastrocrom, Gastrocrom®, Intal®, Nasalcrom®, Opticrom®
Chemical formula:

Cromolyn Sodium oral solution
What is cromolyn sodium oral solution?
CROMOLYN SODIUM (Gastrocrom®) helps to treat mastocytosis. This is a rare condition in which the body makes too many mast cells, releasing substances that cause headaches; stomach problems (nausea, vomiting, diarrhea, or pain); or skin reactions (flushing, hives, itching). This drug is also used to treat inflammatory bowel conditions, like ulcerative colitis. Generic cromolyn oral solution is not yet available.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
liver disease
kidney disease
an unusual or allergic reaction to cromolyn, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
How should I take this medicine?
Take the contents of cromolyn sodium oral concentrate by mouth after preparing the dose in a glass of water. Follow the directions on the prescription label. Open the dosage container and mix the solution contents as directed according to your prescription in at least half a glass (4 fluid ounces) of water. Stir well. Do not mix with fruit juice, milk, carbonated drinks, or foods. Take your dose 30 minutes before food. Take your doses at regular intervals. Do not take your medicine more often than directed.
Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed. Cromolyn oral solution is commonly administered to children.
What if I miss a dose?
If you miss a dose, take it as soon as you can. Then space remaining doses evenly throughout the rest of the day. Do not take double or extra doses.What drug(s) may interact with cromolyn?
There have been no interactions reported between cromolyn and other medicines.
Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
What should I watch for while taking cromolyn?
Visit your prescriber or health care professional for regular checks on your progress. Once your symptoms are improving your prescriber or health care professional may cut down on the number of capsules you need to use in a day. However, do not reduce your dose yourself, a certain dosage must be maintained at regular intervals to control your symptoms.
What side effects may I notice from taking cromolyn?
Side effects that you should report to your prescriber or health care professional as soon as possible:
skin rash and itching (hives)
swelling of face, lips, or eyelids
wheezing or continued coughing
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
diarrhea
headache
indigestion or stomach ache
muscle aches
nausea, vomiting
Where can I keep my medicine?
Keep out of the reach of children in a container that small children cannot open.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Keep the drug containers in the foil pouch until time of use. Once a container is opened, you should throw away any unused solution in the open container. Throw away any unused medicine after the expiration date.
Last updated: 7/1/2002
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
|
Cromoglicate
|
|
| Systematic (IUPAC) name | |
| 5-[3-(2-carboxy-4-oxo-chromen-6-yl) oxy-2-hydroxy-propoxy]- 4-oxo-chromene-2-carboxylic acid | |
| Identifiers | |
| CAS number | |
| ATC code | R03 R01AC01 A07EB01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C23H16O11 |
| Mol. mass | 468.367 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 1% |
| Metabolism | ? |
| Half life | 1.3 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
inhaler POM, eye OTC(UK) |
| Routes | topical: oral, nasal spray, inhaled, eye drops |
Cromoglicate (INN) (also referred to as cromolyn
(USAN) or cromoglycate (former BAN)) is traditionally described as a mast cell
stabilizer, and is commonly marketed as the sodium salt sodium cromoglicate. This drug prevents the release of
inflammatory chemicals such as histamine from
It is available as a nasal spray (Rynacrom®(UK), Nasalcrom®) to treat allergic rhinitis, as an inhaler (Intal®) for preventive management of asthma, as eye drops (Opticrom® and Optrex Allergy® (UK), Crolom®) for allergic conjunctivitis, or in an oral form (Gastrocrom®) to treat mastocytosis, dermatographic urticaria and ulcerative colitis.
Sodium cromoglicate has also been shown to reduce symptoms of food allergies, including some cases of chronic migraines.[citation needed]
The underlying mechanism of action is not fully understood; for while cromoglicate stabilizes mast cells, this mechanism is probably not why it works in asthma.[citation needed] Pharmaceutical companies have produced 20 related compounds that are equally or more potent at stabilising mast cells and none of them have shown any anti-asthmatic effect.[citation needed] It is more likely that these work by inhibiting the response of sensory C fibres to the irritant capsacin, inhibiting local axon reflexes involved in asthma, and may inhibit the release of preformed T cell cytokines and mediators involved in asthma. (see review by Garland, 1991)
Allegic reactions may include severe rash internally and externally.
It is known to somewhat inhibit chloride channels (37% +/- 7%) [1] and thus may inhibit the:
Note: Another chemical (NPPB (5-nitro-2(3-phenyl) propylamino-benzoic acid)) was shown, in the same study, to be a more effective chloride channel blocker.
Finally it may act by inhibiting calcium influx.
Cromoglicate is classified as a chromone.
| Antidiarrheals, intestinal anti-inflammatory/anti-infective agents (A07) | |
|---|---|
| Intestinal anti-infectives | Antibiotics (Neomycin, Nystatin, Natamycin, Streptomycin, Polymyxin B, Paromomycin, Amphotericin B, Kanamycin, Vancomycin, Colistin, Rifaximin) - Sulfonamides (Phthalylsulfathiazole, Sulfaguanidine, Succinylsulfathiazole) - other (Miconazole, Broxyquinoline, Acetarsol, Nifuroxazide, Nifurzide) |
| Intestinal adsorbents | Charcoal - Bismuth - Pectin - Kaolin - Crospovidone - Attapulgite - Diosmectite |
| Antipropulsives | Diphenoxylate - Opium - Loperamide - Difenoxin - Loperamide oxide |
| Intestinal anti-inflammatory agents | corticosteroids acting locally (Prednisolone, Hydrocortisone, Prednisone, Betamethasone, Tixocortol, Budesonide, Beclometasone) - antiallergic agents, excluding corticosteroids (Cromoglicic acid) - aminosalicylic acid and similar agents (Sulfasalazine, Mesalazine, Olsalazine, Balsalazide) |
| Antidiarrheal micro-organisms | Saccharomyces boulardii |
| Other antidiarrheals | Albumin tannate - Ceratonia - Racecadotril |
| Decongestants and other nasal preparations (R01) | |
|---|---|
| Topical: sympathomimetics, plain | Cyclopentamine - Ephedrine - Phenylephrine - Oxymetazoline - Tetryzoline - Xylometazoline - Naphazoline - Tramazoline - Metizoline - Tuaminoheptane - Fenoxazoline - Tymazoline - Epinephrine |
| Topical: antiallergic agents, excluding corticosteroids | Cromoglicic acid - Levocabastine - Azelastine - Antazoline - Spaglumic acid - Thonzylamine - Nedocromil - Olopatadine |
| Topical: corticosteroids | Beclometasone - Prednisolone - Dexamethasone - Flunisolide - Budesonide - Betamethasone - Tixocortol - Fluticasone - Mometasone furoate - Triamcinolone |
| Topical: other nasal preparations | Calcium hexamine thiocyanate - Retinol - Ipratropium bromide - Ritiometan - Mupirocin - Hexamidine - Framycetin |
| Systemic use: Sympathomimetics | Phenylpropanolamine - Pseudoephedrine - Phenylephrine |
| Drugs for obstructive airway diseases: asthma/COPD (R03) | |
|---|---|
| Adrenergics, inhalants | Short
acting β2-agonists: Salbutamol/Levosalbutamol • Fenoterol • Terbutaline Long acting β2-agonists (LABA): Bambuterol • Clenbuterol • Formoterol • Salmeterol other: Epinephrine • Isoproterenol • Orciprenaline |
| Glucocorticoids | Beclometasone • Budesonide • Ciclesonide • Fluticasone • Mometasone |
| Anticholinergics | Ipratropium • Tiotropium |
| Mast cell stabilizers | Cromoglicate • Nedocromil |
| Xanthines | Aminophylline • Theobromine • Theophylline |
| Leukotriene antagonists | Montelukast • Pranlukast • Zafirlukast |
| Combination products | Budesonide/formoterol • Fluticasone/salmeterol • Ipratropium/salbutamol |
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
Join the WikiAnswers Q&A community. Post a question or answer questions about "cromolyn sodium" at WikiAnswers.
Copyrights:
![]() | Dictionary. The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2007, 2000 by Houghton Mifflin Company. Updated in 2007. Published by Houghton Mifflin Company. All rights reserved. Read more | |
![]() | Dental Dictionary. Mosby's Dental Dictionary. Copyright © 2004 by Elsevier, Inc. All rights reserved. Read more | |
![]() | Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved. Read more | |
![]() | Wikipedia. This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Cromoglicate". Read more |
Mentioned In: