Results for cromolyn sodium
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Dictionary:

cromolyn sodium

  (krō'mə-lĭn) pronunciation
n.

A drug, C23H14Na2O11, usually administered by inhalation and used to prevent certain allergic attacks, especially those associated with asthma or hay fever.

[Alteration of chromonyl, one of its constituents (CHROM(O)– + –ON(E) + –YL) + SODIUM.]


 
 
Dental Dictionary: cromolyn sodium

n

trade names: Intal, Nasalcrom, Rynacrom; drug class: antiasthmatic; action: stabilizes the membrane of the sensitized mast cell, preventing release of chemical mediators; uses: allergic rhinitis, severe perennial bronchial asthma, exercise-induced broncho-spasm.

 
Drug Info: Cromolyn Sodium

Brand names: Crolom®, Gastrocrom, Gastrocrom®, Intal®, Nasalcrom®, Opticrom®

Chemical formula:



Cromolyn Sodium oral solution

What is cromolyn sodium oral solution?

CROMOLYN SODIUM (Gastrocrom®) helps to treat mastocytosis. This is a rare condition in which the body makes too many mast cells, releasing substances that cause headaches; stomach problems (nausea, vomiting, diarrhea, or pain); or skin reactions (flushing, hives, itching). This drug is also used to treat inflammatory bowel conditions, like ulcerative colitis. Generic cromolyn oral solution is not yet available.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
• liver disease
• kidney disease
• an unusual or allergic reaction to cromolyn, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I take this medicine?

Take the contents of cromolyn sodium oral concentrate by mouth after preparing the dose in a glass of water. Follow the directions on the prescription label. Open the dosage container and mix the solution contents as directed according to your prescription in at least half a glass (4 fluid ounces) of water. Stir well. Do not mix with fruit juice, milk, carbonated drinks, or foods. Take your dose 30 minutes before food. Take your doses at regular intervals. Do not take your medicine more often than directed.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed. Cromolyn oral solution is commonly administered to children.

What if I miss a dose?

If you miss a dose, take it as soon as you can. Then space remaining doses evenly throughout the rest of the day. Do not take double or extra doses.

What drug(s) may interact with cromolyn?

There have been no interactions reported between cromolyn and other medicines.

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What should I watch for while taking cromolyn?

Visit your prescriber or health care professional for regular checks on your progress. Once your symptoms are improving your prescriber or health care professional may cut down on the number of capsules you need to use in a day. However, do not reduce your dose yourself, a certain dosage must be maintained at regular intervals to control your symptoms.

What side effects may I notice from taking cromolyn?

Side effects that you should report to your prescriber or health care professional as soon as possible:
• skin rash and itching (hives)
• swelling of face, lips, or eyelids
• wheezing or continued coughing

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• diarrhea
• headache
• indigestion or stomach ache
• muscle aches
• nausea, vomiting

Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Keep the drug containers in the foil pouch until time of use. Once a container is opened, you should throw away any unused solution in the open container. Throw away any unused medicine after the expiration date.

Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

 
Wikipedia: cromoglicate
Cromoglycate.png
Cromoglicate
Systematic (IUPAC) name
5-[3-(2-carboxy-4-oxo-chromen-6-yl) oxy-2-hydroxy-propoxy]- 4-oxo-chromene-2-carboxylic acid
Identifiers
CAS number 16110-51-3
ATC code R03BC01 R01AC01 A07EB01
PubChem 27686
DrugBank APRD00336
Chemical data
Formula C23H16O11 
Mol. mass 468.367 g/mol
Pharmacokinetic data
Bioavailability 1%
Metabolism  ?
Half life 1.3 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status

inhaler POM, eye OTC(UK)

Routes topical: oral, nasal spray, inhaled, eye drops

Cromoglicate (INN) (also referred to as cromolyn (USAN) or cromoglycate (former BAN)) is traditionally described as a mast cell stabilizer, and is commonly marketed as the sodium salt sodium cromoglicate. This drug prevents the release of inflammatory chemicals such as histamine from mast cells.

Uses

It is available as a nasal spray (Rynacrom®(UK), Nasalcrom®) to treat allergic rhinitis, as an inhaler (Intal®) for preventive management of asthma, as eye drops (Opticrom® and Optrex Allergy® (UK), Crolom®) for allergic conjunctivitis, or in an oral form (Gastrocrom®) to treat mastocytosis, dermatographic urticaria and ulcerative colitis.

Sodium cromoglicate has also been shown to reduce symptoms of food allergies, including some cases of chronic migraines.[citation needed]

Mechanism of action

The underlying mechanism of action is not fully understood; for while cromoglicate stabilizes mast cells, this mechanism is probably not why it works in asthma.[citation needed] Pharmaceutical companies have produced 20 related compounds that are equally or more potent at stabilising mast cells and none of them have shown any anti-asthmatic effect.[citation needed] It is more likely that these work by inhibiting the response of sensory C fibres to the irritant capsacin, inhibiting local axon reflexes involved in asthma, and may inhibit the release of preformed T cell cytokines and mediators involved in asthma. (see review by Garland, 1991)

Allergic reactions

Allegic reactions may include severe rash internally and externally.

It is known to somewhat inhibit chloride channels (37% +/- 7%) [1] and thus may inhibit the:

  • exaggerated neuronal reflexes triggered by stimulation of irritant receptors on sensory nerve endings (e.g. exercise-induced asthma)
  • release of preformed cytokines from several type of inflammatory cells (T cells, eosinophils) in allergen-induced asthma

Note: Another chemical (NPPB (5-nitro-2(3-phenyl) propylamino-benzoic acid)) was shown, in the same study, to be a more effective chloride channel blocker.

Finally it may act by inhibiting calcium influx.

Cromoglicate is classified as a chromone.

References

  1. ^ Heinke, S; Szucs G, Norris A, Droogmans G, Nilius B (August 1995). "Inhibition of volume-activated chloride currents in endothelial cells by chromones". Br J Pharmacol. 115(8): 1393-8. PMID 8564197. 

 
 

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Copyrights:

Dictionary. The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2007, 2000 by Houghton Mifflin Company. Updated in 2007. Published by Houghton Mifflin Company. All rights reserved.  Read more
Dental Dictionary. Mosby's Dental Dictionary. Copyright © 2004 by Elsevier, Inc. All rights reserved.  Read more
Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved.  Read more
Wikipedia. This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Cromoglicate" Read more

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