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Yes. There is scientific evidence to indicate that Halothane is able to induce cytochrome P450. P450 in turn anaerobically reduces halothane to potentially toxic metabolic compounds that cause liver damage

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Cimetidine

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Cytochrome P450 allows phenytoin to undergo aromatic hydroxylation to turn into phenol.

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The human cytochrome P450 comprises 57 genes. These genes code for enzymes that can have a role in: metabolism of drugs, foreign chemicals, cholesterol metabolism and more. P450 was once thought to be mainly a hepatic drug detoxication system, its now believed to include a myriad of enzymic reactions implicated in important life processes.

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