Daidzein

Daidzein
IUPAC name	7-Hydroxy-3-(4-hydroxyphenyl) chromen-4-one
Other names	4',7-Dihydroxyisoflavone Daidzeol Isoaurostatin
Identifiers
CAS number	[486-66-8]
PubChem	5281708
SMILES	C1=CC(=CC=C1C2=COC3=C(C2=O) C=CC(=C3)O)O
Properties
Molecular formula	C15H10O4
Molar mass	254.23 g/mol
Exact mass	254.057909
Appearance	Pale yellow prisms
Melting point	315-323 °C (decomposes)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Daidzein is one of several known isoflavones. Isoflavones compounds, such as daidzein and genistein, are found in a number of plants and herbs like the Thai Kwao Krua or Pueraria Mirifica, but soybeans and soy products like tofu and textured vegetable protein are the primary food source. Soy isoflavones are a group of compounds found in and isolated from the soybean. Besides functioning as antioxidants, many isoflavones have been shown to interact with animal and human estrogen receptors, and are therefore known as phytoestrogens. Soy isoflavones also produce non-hormonal effects.

Isoflavones act as antioxidants to counteract damaging effects of free radicals in tissues. Isoflavones can act like estrogen in stimulating development and maintenance of female characteristics or they can block cells from using other forms of estrogen^{[citation needed]}. Isoflavones also have been found to have antiangiogenic effects (blocking formation of new blood vessels)^{[citation needed]}, and may block the uncontrolled cell growth associated with cancer, most likely by inhibiting the activity of substances in the body that regulate cell division and cell survival (growth factors)^{[citation needed]}.

^[1]. Initial studies of soy and Kwao Krua isoflavone mixtures containing genistein, daidzein, and glycitein have found them safe for human use. Laboratory studies using animals models have shown that both soy and isoflavones can be protective against cancer when given during early life but can stimulate response to cancer-causing chemicals when given during fetal development or when circulating levels of estrogen are low (menopause)^{[citation needed]}.

White Kawo Krua, Pueraria mirifica has been found to contain concentrations of daidzein where the Cu²+ at 300 ppm is shown to contain as much as 44.69 ppm of daidzein. Another source of daidzein is Kudzu, Pueraria Lobata.

Glycosides

• Daidzin is the 7-O-glucoside of daidzein.
• Puerarin is the 8-C-glucoside of daidzein.

References

External links