Dantrolene Sodium

Dantrolene is a muscle relaxant that appears to work to prevent the release of calcium. After the widespread introduction of treatment with dantrolene, the mortality of malignant hyperthermia fell from 80% in the 1960s to less than 5%. Azumolene has also been shown to be as effective as dantrolene.

yes

Dantrolene may have an interaction with estrogens. Although no interaction has been demonstrated, the rate of liver damage in women over the age of 35 who were taking estrogens is higher than in other groups.

Dantrolene has a potential for hepatotoxicity. The incidence of symptomatic hepatitis is dose related, but may occur even with a short period of doses at or above 800 mg per day, which greatly increases the risk of serious liver injury.