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David Baltimore

 
Britannica Concise Encyclopedia: David Baltimore
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(born March 7, 1938, New York, N.Y., U.S.) U.S. virologist. He received his doctorate from the Rockefeller Institute. He and Howard Temin (1934 – 94), working independently, discovered an enzyme that synthesizes DNA from RNA, the reverse of the usual process. This enzyme, reverse transcriptase, has become an invaluable tool in recombinant DNA technology. The research of Baltimore, Temin, and Renato Dulbecco helped illuminate the role of viruses in cancer; the three men shared a Nobel Prize in 1975. In 1990 Baltimore became president of Rockefeller University. He served as president of the California Institute of Technology from 1997 to 2006, when he was elected to a three-year term as president of the American Association for the Advancement of Science.

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Scientist: David Baltimore
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American molecular biologist (1938–)

Baltimore was born in New York City and studied chemistry at Swarthmore College. He continued with postgraduate work at the Massachusetts Institute of Technology, and at Rockefeller University, where he obtained his PhD in 1964. After three years at the Salk Institute in California, he returned to MIT in 1968 where, in 1972, he became professor of biology.

Francis Crick had formulated what came to be known as the Central Dogma of molecular biology, namely, that information could flow from DNA to RNA to protein but could not flow backward from protein to either DNA or RNA. Although he had not actually excluded the passage of information from RNA to DNA it became widely assumed that such a flow was equally forbidden. In June 1970 Baltimore and, quite independently, Howard Temin announced the discovery of an enzyme later to be known as reverse transcriptase, which is capable of transcribing RNA into DNA. Apparently certain viruses, like the RNA tumor viruses used by Baltimore, could produce DNA from an RNA template. For this work Baltimore shared the 1975 Nobel Prize for physiology or medicine with Temin and Renato Dulbecco. A few years later their work took on an added significance when Gallo and Montagnier identified a retrovirus as the cause of AIDS.

Earlier (1968) Baltimore had done important work on the replication of the polio virus. He revealed that the RNA of the virus first constructed a ‘polyprotein’ (or giant protein molecule), which then split into a number of smaller protein molecules. Two of these polymerized further RNA while the remainder formed the protein coat of the new viral particles.

In 1982 Baltimore became founding director of the Whitehead Institute, Cambridge, Massachusetts, a research biomedical foundation backed by the industrialist E. C. Whitehead. While at Whitehead, in collaboration with D. Schatz, he identified two antibody genes, RAG-1 and RAG-2. In 1990 Baltimore was appointed president of Rockefeller University; it was not to prove a fruitful or happy time. Many staff opposed the appointment and Baltimore became involved in a bitter controversy. It had been claimed that a paper co-authored by Baltimore and published in 1986 in Cell was based on falsified data. Although Baltimore withdrew his name from the paper, the public controversy persisted in Congressional hearings and the correspondence columns of Nature. Baltimore resigned the presidency in 1992 and returned to MIT in 1994 as professor of molecular biology.

Biography: David Baltimore
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The American virologist David Baltimore (born 1938) received the Nobel Prize in Physiology and Medicine for his work on retrovirus biochemistry and its significance for cancer research.

David Baltimore was born on March 7, 1938, in New York City, the son of Richard I. and Gertrude (Lipschitz) Baltimore. While still a high school student, he spent a summer at the Jackson Memorial Laboratory in Bar Harbor, Maine, experiencing biology under actual research conditions. This so affected him that upon entering Swarthmore College in 1956 he declared himself a biology major. Later he switched to chemistry to complete a research thesis and graduated in 1960 with a B.A. and high honors. Between his sophomore and junior years at Swarthmore, he spent a summer at the Cold Spring Harbor Laboratories, where the influence of George Streisinger led him to molecular biology.

Baltimore spent two years of graduate work at Massachusetts Institute of Technology (MIT) in biophysics, then left for a summer with Philip Marcus at the Albert Einstein Medical College and to take the animal virus course at Cold Spring Harbor under Richard Franklin and Edward Simon. He then joined Franklin at the Rockefeller Institute, completing his thesis by 1964 and staying on as a postdoctoral fellow in animal virology with James Darnell.

In 1965 he became a research associate at the Salk Institute of Biological Studies, working in association with Renato Dulbecco. Here he first met Alice S. Huang, with whom he also conducted research. He and Huang were married on October 5, 1968, and that same year they returned to MIT, where he held the position of associate professor of microbiology until 1971. In 1972 he rose to full professorship, and in 1974 he joined the staff of the MIT Center for Cancer Research under Salvador Luria.

Received Recognition For Cancer and Immunology Research

Baltimore received many awards for his work. In 1971 he was the recipient of the Gustav Stern award in virology, the Warren Triennial Prize, and the Eli Lilly and Co. award in microbiology and immunology. A year after being promoted to full professorship at MIT, he was rewarded a lifetime research professorship by the American Cancer Society. In 1974 he was presented with the U.S. Steel Foundation award in molecular biology and the Gairdner Foundation Annual Award. His most prestigious award came in 1975 when he shared the Nobel Prize in Physiology and Medicine with Howard M. Temin and Renato Dulbecco for research on retro-viruses and cancer. Much of this work concentrated upon protein and nucleic acid synthesis of RNA (ribonucleic acid) animal viruses, especially polio-virus and the RNA tumor virus. His research demonstrated that the flow of genetic information in such viruses did not have to go from DNA (deoxyribonucleic acid) to RNA but could flow from RNA to DNA, a finding which undermined the central dogma of molecular biology - i.e., unilinear information flow from DNA to proteins. This process came to be called, facetiously, "reverse transcriptase."

Baltimore's interests later took him further into the study of how viruses reproduce themselves and into work on the immune systems of animals and humans, where he concentrated upon the process by which antibodies may develop. Central to much of this work was DNA technology, in which he maintained an active interest.

Baltimore proved himself an effective educator, conducting seminars with graduate students and younger colleagues. He also became successful at directing research rather than doing it himself, again working closely with students.

Research Debacle

In 1989 Thereza Imanishi-Kari, a collegue with whom he co-authored a 1986 paper on immunology for Cell, was charged with falsifying data. Imanishi-Kari, a Massachussets Institute of Technology Assistant Professor, was absolved when a top government ethics panel declared they found no wrongdoing in 1996. Although Baltimore was never implicated in any wrongdoing, the incident caused him to withdraw the paper. He was also pressured by colleagues to resign from his presidency at New York's Rockefeller University, which he did in 1991.

Baltimore Chairs AIDS Vaccine Research Panel

In December 1996, Baltimore became the head of a new AIDS vaccine research panel for the Office of AIDS Research at the National Institute of Health. The panel was formed to step up the search for an AIDS vaccine. He also became the President of the California Institute of Technology in 1997.

Further Reading

Short biographies of David Baltimore can be found in the 39th edition of Who's Who in America (1976-1977) and in the 14th edition of American Men and Women of Science: Physical and Biological Sciences (1979). He provided an autobiographical sketch in the Nobel Lectures (1977), and a New York Times interview (August 26, 1980) gives additional information.

For further reading, see: Appeals Panel Reverses Fraud Finding by K. Fackelmann in Science News, July 6, 1996; Baltimore to Head New Vaccine Panel by Jon Cohen in Science, December 20, 1996; and A Shot In the Arm by Mark Schoofs, The Village Voice, December 24, 1996.

 
Columbia Encyclopedia: David Baltimore
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Baltimore, David (bôl'tĭmôr, -mər), 1938-, American microbiologist, b. New York City, Ph.D. Rockefeller Univ., 1964. He conducted (1965-68) virology research at the Salk Institute before becoming a professor at Massachusetts Institute of Technology in 1972. In 1970 he and his wife Alice Huang discovered a virus caused by an enzyme that could transcribe DNA into RNA. He shared the 1975 Nobel Prize in Physiology or Medicine with Renato Dulbecco and Howard Temin for his study on the connections between viruses and cancer.

Appointed president of Rockefeller Univ. in 1990, he resigned the next year after a scientific fraud scandal. A paper he coauthored was said to contain fraudulent data from another author, Dr. Thereza Imanishi-Kari, and Baltimore was criticized for his vehement defense of the paper despite the evidence. In 1996, an appeals panel overturned the verdict of the original investigating office, the federal Office of Scientific Integrity (now the Office of Reasearch Integrity), and Baltimore and Imanishi-Kari were exonerated. In 1997 Baltimore was appointed president of the California Institute of Technology.

Bibliography

See D. J. Kevles, The Baltimore Case: A Trial of Politics, Science, and Character (1998).

Wikipedia: David Baltimore
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David Baltimore

David L. Baltimore
Born 7 March 1938(1938-03-07)
New York City, New York, USA
Nationality United States
Fields Biology
Institutions Massachusetts Institute of Technology
Rockefeller University
California Institute of Technology
Alma mater Swarthmore College
Rockefeller University
Known for Reverse transcriptase
Notable awards Nobel Prize in Physiology or Medicine (1975)

David L. Baltimore (born 7 March 1938) is an American biologist, university administrator, and Nobel laureate in Physiology or Medicine. He served as president of the California Institute of Technology (Caltech) from 1997 to 2006, and is currently the Robert A. Millikan Professor of Biology at Caltech. He also served as president of Rockefeller University from 1990 to 1991, and was president of the American Association for the Advancement of Science in 2007. As is traditional in the AAAS, he now serves as the Chairman of the Board of Directors.

Contents

Biography

Early years

Baltimore was born to Gertrude Lipschitz and Richard Baltimore in New York City. He graduated from Great Neck High School in 1956, and credits his interest in biology to a high-school summer spent at the Jackson Laboratory in Bar Harbor, Maine.[1][2] He earned a BA at Swarthmore College in 1960, and received his Ph.D. at Rockefeller University in 1964. After postdoctoral fellowships at Massachusetts Institute of Technology (MIT) and Albert Einstein College of Medicine and a non-faculty research position at the Salk Institute, he joined the MIT faculty in 1968.

Career

In 1975, at the age of 37, he shared the Nobel Prize for Physiology or Medicine with Howard Temin and Renato Dulbecco. The citation reads, "for their discoveries concerning the interaction between tumour viruses and the genetic material of the cell." At the time, Baltimore's greatest contribution to virology was his discovery of reverse transcriptase (RTase or RT). Reverse transcriptase is essential for the reproduction of retroviruses such as HIV and was also discovered independently, and at about the same time, by Mizutani and Temin.[3]

Also in 1975, Baltimore was an organizer of the Asilomar conference on recombinant DNA. In 1982, Baltimore was appointed the founding director of MIT's Whitehead Institute, where he remained through June 1990.

In 1981, Baltimore and Vincent Racaniello, a post-doctoral fellow in his laboratory, used recombinant DNA technology to generate a plasmid encoding the genome of poliovirus, an animal RNA virus. The plasmid DNA was introduced into cultured mammalian cells and infectious poliovirus was produced.[4] The infectious clone, DNA encoding the genome of a virus, is a standard tool used today in virology. Other important breakthroughs from Baltimore's lab include the discovery the transcription factor NF-kB and the recombination activating genes RAG-1 and RAG-2.

Baltimore became president of Rockefeller University in New York City on 1 July, 1990. After resigning on 3 December 1991, Baltimore remained on the Rockefeller University faculty and continued research until spring of 1994. He then rejoined the MIT faculty.

Baltimore has influenced national policy concerning recombinant DNA research and the AIDS epidemic. He has trained many doctoral students and postdoctoral fellows, several of whom have gone on to notable and distinguished research careers. Baltimore is a member of The Jackson Laboratory's Board of Trustees, the Bulletin of the Atomic Scientists' Board of Sponsors, the National Academy of Sciences USA (NAS), the NAS Institute of Medicine (IOM), Amgen, Inc. Board of Directors, the BB Biotech AG Board of Directors, the National Institutes of Health (NIH) AIDS Vaccine Research Committee (AVRC), and numerous other organizations and their boards. He is married to Alice S. Huang.

Imanishi-Kari case

Main article: Thereza Imanishi-Kari

By 1996, the New York Times called the Imanishi-Kari case "The fraud case that evaporated," after an appeals panel found that "the Government failed to prove any of the 19 charges leveled against Dr. Imanishi-Kari."[5][6] But during the late 1980s and early 1990s, the case was a cause celebre, spawning extensive news coverage and a Congressional investigation. The case was linked to Baltimore's name because of his scientific collaboration with and later his strong defense of Imanishi-Kari against accusations of fraud.

In 1986, while a Professor of Biology at MIT and Director at Whitehead, Baltimore co-authored a scientific paper on immunology with Thereza Imanishi-Kari (an Assistant Professor of Biology who had her own laboratory at MIT) as well as four others.[7] A postdoctoral fellow in Imanishi-Kari's laboratory, Margot O'Toole, who was not an author, reported concerns about the paper, ultimately accusing Imanishi-Kari of fabricating data in a cover-up. Baltimore, however, refused to retract the paper.

O'Toole soon dropped her challenge, but the NIH, which had funded the contested paper's research, began investigating. Representative John Dingell (D-MI) also aggressively pursued it, eventually calling in U.S. Secret Service (USSS; U.S. Treasury) document examiners.[8]

In a draft report dated March 14, 1991 and based mainly on USSS forensics findings, NIH's fraud unit, then called the Office of Scientific Integrity (OSI), accused Imanishi-Kari of falsifying and fabricating data. It also criticized Baltimore for failing to embrace O'Toole's challenge.[citation needed] Less than a week later, the report was leaked to the press.[9] Baltimore and three co-authors then retracted the paper; Imanishi-Kari and Moema H. Reis did not sign the retraction.[10]

Amid concerns raised by negative publicity in connection with the scandal, Baltimore resigned as president of Rockefeller University[11] and rejoined the MIT Biology faculty.[12]

In July 1992, the US Attorney for the District of MD, who had been investigating the case, announced he would bring neither criminal nor civil charges against Imanishi-Kari.[13] In October 1994, however, OSI's successor, the Office of Research Integrity (ORI; HHS) found Imanishi-Kari guilty on 19 counts of research misconduct, basing its conclusions largely on Secret Service analysis of laboratory notebooks.

An HHS appeals panel began meeting in June 1995 to review all charges in detail. In June 1996, the panel ruled that the ORI had failed to prove even one of its 19 charges. Citing repeated instances where Dr. O'Toole's allegations were "not credible", the panel dismissed all charges against Imanishi-Kari. Furthermore, as their final report stated, the HHS panel "found that much of what ORI presented was irrelevant, had limited probative value, was internally inconsistent, lacked reliability or foundation, was not credible or not corroborated, or was based on unwarranted assumptions." Neither OSI nor ORI ever accused Baltimore of research misconduct.[14][15]

Baltimore has been both praised and criticized for his actions in this matter.[16][17][18][19][20][21][22] Historian of science Daniel Kevles recounts the affair in his 1998 book, The Baltimore Case,[23][24] while Yale University mathematician Serge Lang strongly criticized Baltimore's behavior.[25] Baltimore has also written his own analysis.[26]

Caltech

On 13 May 1997, Baltimore was appointed president of the California Institute of Technology (Caltech).[27] He began serving in the office 15 October 1997 and was inaugurated 9 March 1998.[28]

During Baltimore's tenure at Caltech, United States President Bill Clinton awarded Baltimore the National Medal of Science in 1999 for his numerous contributions to the scientific world. In 2004, Rockefeller University gave Baltimore its highest honor, Doctor of Science (honoris causa).[29]

In October 2005, Baltimore resigned the office of the president,[30] saying, "This is not a decision that I have made easily, but I am convinced that the interests of the Institute will be best served by a presidential transition at this particular time in its history..."[31] Former Georgia Tech Provost Jean-Lou Chameau succeeded Baltimore as president of Caltech.[32] Baltimore remains the Millikan Professor of Biology at Caltech and is an active member of the Institute's community.

Soon after Baltimore's resignation, and at his request, Caltech began investigating the work Luk van Parijs had conducted while a postdoc in Baltimore's laboratory.[33] Van Parijs first came under suspicion at MIT, for work done after he had left Baltimore's lab. After van Parijs had been fired by MIT, his doctoral supervisor also noted problems with work van Parijs did at the Brigham and Women's Hospital, before leaving Harvard to go to Baltimore's lab.[34] Concluding in March 2007, the Caltech investigation found van Parijs alone committed research misconduct and that four papers co-authored by Baltimore, van Parijs, and others required correction.[35]

Personal life

Baltimore was married in 1968 to Alice S. Huang. They have one daughter.

See also

References

  1. ^ Nobel Prize autobiography
  2. ^ Kerr, Kathleen. "They Began Here", Newsday. Accessed 23 Oct 2007. "David Baltimore, 1975 Nobel laureate and one of the nation's best-known scientists, is a good case in point. The 60-year-old Baltimore, who graduated from Great Neck High School in 1956..."
  3. ^ Judson, Horace F (2003-10-20). "No Nobel Prize for Whining". New York Times. http://query.nytimes.com/gst/fullpage.html?sec=health&res=9C02E4DE123EF933A15753C1A9659C8B63. Retrieved 2007-08-03. 
  4. ^ Racaniello V, Baltimore D (1981). "Cloned poliovirus complemenatry DNA is infectious in mammalian cells". Science 214 (453): 916–919. doi:10.1126/science.6272391. PMID 6272391. 
  5. ^ http://www.nytimes.com/books/98/09/20/specials/baltimore-evaporated.html?scp=30&sq=david-baltimore&st=cse
  6. ^ 1996 HHS conclusions vindicating Imanishi-Kari
  7. ^ Weaver D, Reis MH, Albanese C, Costantini F, Baltimore D, and Imanishi-Kari T (1986) Altered repertoire of endogenous immunoglobulin gene expression in transgenic mice containing a rearranged mu heavy chain gene. Cell 45(2): 247-59 (25 April) (PMID 3084104)
  8. ^ "Fraud in NIH Grant Programs," 12 April 1988; "Scientific Fraud," 4 & 9 May 1989; and "Scientific Fraud (Part 2)," 14 May 1990 (transcript includes 30 April 1990 hearing on R. Gallo's NIH lab)
  9. ^ Philip J. Hilts, "Crucial Data Were Fabricated In Report Signed by Top Biologist; Nobel Winner Is Asking That Paper Be Retracted" (New York Times, 21 March 1991, Pp. A1, B10)
  10. ^ Weaver D, Albanese C, Costantini F, and Baltimore D (1991) Retraction: Altered repertoire of endogenous immunoglobulin gene expression in transgenic mice containing a rearranged mu heavy chain gene. Cell 65(4): 536 (17 May) PMID 2032282
  11. ^ Hall, Stephen S. (1991) David Baltimore's Final Days. Science 254(5038): 1576-9 (13 Dec.) PMID 1749930 or here
  12. ^ Natalie Angier, "Embattled Biologist Will Return to M.I.T." (New York Times, 19 May 1992, P. C5)
  13. ^ Malcolm Gladwell, "Prosecutors Halt Scientific Fraud Probe; Researcher Baltimore Claims Vindication, Plans to 'Unretract' Paper" (Washington Post, 14 July 1992, P. A3); Hamilton, D.P. (1992) U.S. attorney decides not to prosecute Imanishi-Kari. Science 257(5068): 318 (17 July) PMID 1321499
  14. ^ 1996 HHS report exonerating Imanishi-Kari
  15. ^ Boston Globe, 1996, "The public skirmish over the reputations of Massachusetts Institute of Technology professor David Baltimore and Tufts University researcher Thereza Imanishi-Kari has been formally ended by a report deeply embarrassing to the government."
  16. ^ Judy Foreman, "Baltimore Speaks Out on Disputed Study in Letter Sent to Colleagues Around the Nation; He Calls for Protection Against ‘threats’ to Scientific Freedom" (Boston Globe, 23 May 1988, P. 31)
  17. ^ Larry Thompson, "Science Under Fire; Behind the Clash Between Congress and Nobel Laureate David Baltimore" (Washington Post "Health" journal, 5(19): 12-6 (9 May 1989))
  18. ^ 1989 NYT Magazine "This spectacle of damaged reputation was not just unseemly, but difficult to reconcile with the 51-year-old Baltimore's prominence and achievements."
  19. ^ J. Foreman, "MIT Institute Used Funds Wrongly" (Boston Globe, 17 April 1991, P. 1)
  20. ^ Horace Freeland Judson, The Great Betrayal: Fraud in Science (Orlando: Harcourt; 2004)
  21. ^ Daneil Kevles, 1996, abstract of article in New Yorker
  22. ^ Review in Nature 2001
  23. ^ Daniel J. Kevles, The Baltimore Case: A Trial of Politics, Science, and Character (New York: W.W. Norton & Co, Inc.; 1998)
  24. ^ Gunsalus, C.K. (1999) Review of Kevles' "The Baltimore Case..." New England Journal of Medicine 340(3): 242 [21 Jan.]
  25. ^ Lang S. (1993) Questions of Scientific Responsibility: The Baltimore Case. Ethics & Behavior 3(1): 3-72 PMID 11653082
  26. ^ David Baltimore, 1989 (updated 2003)
  27. ^ Caltech Media Relations, "Nobel Prize-winning Biologist David Baltimore Named President of the California Institute of Technology," 13 May 1997 [1] or w/ photos & links; Richard Saltus, "MIT Laureate to Lead Caltech: Baltimore Weathered Data Dispute" (Boston Globe, 14 May 1997, P. A3); Robert Lee Hotz, "Prominent Biology Nobelist Chosen to Head Caltech; Controversial and outspoken scientist David Baltimore says his appointment reflects school's desire for bigger role in nation's scientific debates." (Los Angeles Times, 14 May 1997, Pp. A1, 22, 23); unsigned editorial, "A Luminary of Science for Caltech's Presidency; Nobelist Baltimore has the needed background and clout." (LA Times, 15 May 1997, P. B8); R.L. Hotz, "Biomedicine's Bionic Man; Among the Nation's Most Distinguished - and Controversial - Scientists, Caltech's David Baltimore Now Faces the Dual Challenge of Leading a Premier Research University and Vanquishing AIDS." (LA Times Magazine, 28 Sept. 1997, Pp. 10-13, 34-5)
  28. ^ Caltech Media Relations, "New Caltech President To Be Honored with Formal Inauguration, Birthday Festschrift," 23 February 1998 [2]
  29. ^ Bhattacharjee, Y., ed. (2004) The Balance of Justice. Science 304(5679): 1901 (25 June) [3]
  30. ^ LATimes.com, "Caltech President Baltimore Announces Retirement," 3 October 2005 & R.L. Hotz, "Caltech President Who Raised School's Profile to Step Down" (LA Times, 4 October 2005, P. A1)
  31. ^ Caltech Media Relations, "Baltimore to Retire as Caltech President; Will Remain at Institute as Biology Professor," 3 October 2005 [4]
  32. ^ Caltech Media Relations, "Caltech Presidential Inauguration - A Student Affair," 30 April 2007 [5]
  33. ^ Lois E. Beckett, "MIT Professor Fired for Faking Data; MIT biologist and HMS grad may also have falsified data in work at Harvard" (Harvard Crimson, 31 October 2005) [6]
  34. ^ Boston Globe, October 29, 2005
  35. ^ Reich, E.S. (2007) Scientific misconduct report still under wraps. New Scientist ?(2361): 16 (24 Nov.)

External links

  • Caltech Biology Division Faculty member page
  • Baltimore Laboratory at Caltech site
  • Autobiography at Nobelprize.org
  • Initial reports of ribonucleic acid-dependent DNA polymerase activity:
  1. Baltimore D (1970) RNA-dependent DNA polymerase in virions of RNA tumour viruses. Nature Vol. 226, No. 5252, Pp. 1209-11 (27 June). Entrez Pubmed 4316300
  2. Temin HM and Mizutani S (1970) RNA-dependent DNA polymerase in virions of Rous sarcoma virus. Nature Vol. 226, No. 5252, Pp. 1211-13 (27 June). PMID 4316301
  • Department of Health & Human Services, Departmental Appeals Board, Research Integrity Adjudications Panel Thereza Imanishi-Kari, Ph.D. appeal ruling (Docket No. A-95-33, Decision No. 1582, 21 June 1996; Presentation missing footnotes 169-235 & footnote reference nos. 170-235).
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Nobel Laureates in Physiology or Medicine

Max Theiler (1951) · Selman Waksman (1952) · Hans Krebs / Fritz Lipmann (1953) · John Enders / Thomas Weller / Frederick Robbins (1954) · Hugo Theorell (1955) · André Cournand / Werner Forssmann / Dickinson W. Richards (1956) · Daniel Bovet (1957) · George Beadle / Edward Tatum / Joshua Lederberg (1958) · Severo Ochoa / Arthur Kornberg (1959) · Frank Burnet / Peter Medawar (1960) · Georg von Békésy (1961) · Francis Crick / James D. Watson / Maurice Wilkins (1962) · John Eccles / Alan Hodgkin / Andrew Huxley (1963) · Konrad Bloch / Feodor Lynen (1964) · François Jacob / André Lwoff / Jacques Monod (1965) · Francis Rous / Charles B. Huggins (1966) · Ragnar Granit / Haldan Hartline / George Wald (1967) · Robert W. Holley / Har Khorana / Marshall Nirenberg (1968) · Max Delbrück / Alfred Hershey / Salvador Luria (1969) · Bernard Katz / Ulf von Euler / Julius Axelrod (1970) · Earl Sutherland, Jr. (1971) · Gerald Edelman / Rodney Porter (1972) · Karl von Frisch / Konrad Lorenz / Nikolaas Tinbergen (1973) · Albert Claude / Christian de Duve / George Palade (1974) · David Baltimore / Renato Dulbecco / Howard Temin (1975)
Complete roster · 1901–1925 · 1926–1950 · 1951–1975 · 1976–2000 · 2001–present
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National Medal of Science laureates
 
Biological sciences
1960s
1970s
1970: Barbara McClintock · Albert B. Sabin 1973: Daniel I. Arnon · Earl W. Sutherland, Jr. 1974: Britton Chance · Erwin Chargaff · James V. Neel · James Augustine Hannon 1975: Hallowell Davis · Paul Gyorgy · Sterling Brown Hendricks · Orville lvin Vogel 1976: Roger C.L. Guillemin · Keith Roberts Porter · Efraim Racker · E. O. Wilson 1979: Robert H. Burris · Elizabeth C. Crosby · Arthur Kornberg · Severo Ochoa · Earl Reece Stadtman · George Ledyard Stebbins · Paul Alfred Weiss
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Presidents of the California Institute of Technology

James Augustin Brown Scherer (1908) · Robert Andrews Millikan (1921) · Lee Alvin DuBridge (1946) · Harold Brown (1969) · Robert F. Christy (1977) · Marvin Leonard Goldberger (1978) · Thomas Eugene Everhart (1987) · David Baltimore (1997) · Jean-Lou Chameau (2006)

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