David Crane may refer to:
- David Crane (law), former Chief Prosecutor for the U.N. War Crimes Tribunal for Sierra Leone
- David Crane (programmer), video game designer, programmer and co-founder of Activision
- David Crane (writer/producer), co-creator of the popular TV sitcom Friends
- David Crane (comic strip), created by Win Mortimer
- David Crane, the son of Niles Crane and Daphne Moon on the TV sitcom Frasier
- David Crane (historian)
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