n.
A mucopolysaccharide that is a structural component of certain body tissues, especially the skin.
Dermatan sulfate
| Medical Dictionary: der·ma·tan sulfate |
(dûr'mə-tăn')
n.
n.
| 5min Related Video: Dermatan sulfate |
| Veterinary Dictionary: dermatan sulfate |
A component of the acellular ground substance of skin.
| Wikipedia: Dermatan sulfate |
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Dermatan sulfate
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| ATC code | B01 |
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Dermatan sulfate is a glycosaminoglycan (formerly called a mucopolysaccharide) found mostly in skin, but also in blood vessels, heart valves, tendons, and lungs.
It is also referred to as chondroitin sulfate B, [1] although it is no longer classified as a form of chondroitin sulfate by most sources.
Contents |
Function
Dermatan sulfate may have roles in coagulation, cardiovascular disease, carcinogenesis, infection, wound repair, and fibrosis.
Pathology
Dermatan sulfate accumulates abnormally in several of the mucopolysaccharidosis disorders.
An excess of Dermatan Sulfate in the Mitral Valve is characteristic of myxomatous degeneration of the leaflets leading to redundancy of valve tissue and ultimately, Mitral Valve Prolapse (into the Left atrium) and insufficiency. This chronic prolapse occurs mainly in women over the age of 60, and can predispose the patient to mitral annular calcification. Mitral valve insufficiency can lead to eccentric (volume dependent or dilated) hypertrophy and eventually Left Heart failure if untreated.
See also
External links
References
- ^ Trowbridge, JM; Gallo, RL (September 2002). "Dermatan sulfate: new functions from an old glycosaminoglycan". Glycobiology 12 (9): 117R–25R. doi:. PMID 12213784.
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 | iduronic acid |
| mucopolysaccharidosis |
| Hurler’s syndrome |
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 | Medical Dictionary. The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Read more |
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| Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved. Read more |
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| Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Dermatan sulfate". Read more |
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Mentioned in
- iduronic acid
- mucopolysaccharidosis
- Hurler’s syndrome
- Glycoprotein (biochemistry and molecular biology)
