DME is a three letter acronym referring to one of the following:
- Dubai Mercantile Exchange, a mercantile exchange market in Dubai, United Arab Emirates
- Dakota, Minnesota and Eastern Railroad, a railroad in the US
- Digital Motor Electronics, an automotive engine control system.
- Dimethoxyethane, a solvent.
- Dimethyl ether, a fuel and an aerosol spray propellant.
- Direct Machine Environment, an old operating system for the ICL 2900 Series computing system from ICL.
- Disney's Magical Express, an airport transportation service for Walt Disney World
- Distance measuring equipment, a navigation aid used in aviation.
- DME is the IATA code for Domodedovo International Airport, one of the airports serving Moscow, Russia.
- Diastatic malt extract, used in homebrewing
- Durable medical equipment, a classification of medical devices.
- Diabetic Macular Edema, an opthalmalogical disease
- Dynamic Mobile Exchange, a mobile synchronization product developed by Danish company Excitor A/S
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