Share on Facebook Share on Twitter Email
Answers.com

Docosanol

 
Drug Info: Docosanol

Brand names: Abreva®

Chemical formula:



Docosanol Topical cream

What is this medicine?

DOCOSANOL (doe KOE san ole) skin cream treats herpes virus infections of the face and mouth. These are also known as cold sores or fever blisters. This medicine will help the sores heal faster and relieve the pain or discomfort.
 
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
•immune system problems
•an unusual or allergic reaction to docosanol, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding

How should I use this medicine?

This medicine is for external use on the skin or lips. Do not use in the eye. Follow the directions on the label. Wash hands before and after use. Apply a thin layer of cream to cover the affected area completely. For best results, begin using this medicine at the first signs of a cold sore (tingle). Use your medicine at regular intervals. Do not use your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 12 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What may interact with this medicine?

Interactions are not expected. Do not use any other skin products on the affected area without telling your doctor or health care professional.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Even though you are using this medicine you can still pass herpes to another person. Try to keep the sores (blisters) from making contact with another person's skin.

Tell your doctor or health care professional if your symptoms do not start to get better after 10 days or if they get worse.

You can apply non-medicated cosmetics over the treated area. In order to prevent the spread of infection, use an applicator, like a cotton swab, to apply cosmetics or sunscreen over the cold sore.

Do not get this medicine in your eyes. If you do, rinse out with plenty of cool tap water.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•skin irritation, burning, or itching

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F). Do not freeze. Throw away any unused medicine after the expiration date.

Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

Search unanswered questions...
Enter a question here...
Search: All sources Community Q&A Reference topics
Wikipedia: Docosanol
Top
Docosanol
Systematic (IUPAC) name
docosan-1-ol
Identifiers
CAS number 661-19-8
ATC code D06BB11
PubChem 12620
DrugBank APRD00933
ChemSpider 12100
Chemical data
Formula C22H46O 
Mol. mass 326.6 g/mol
SMILES eMolecules & PubChem
Synonyms 1-Docosanol, n-docosanol, docosyl alcohol, behenic alcohol, behenyl alcohol, Cachalot BE-22, Dehydag wax 22 (lanette), Emery 3304, Loxiol VPG 1451
Physical data
Melt. point 71 °C (160 °F)
Boiling point 180 °C (356 °F)
Pharmacokinetic data
Bioavailability Not absorbed
Metabolism N/A
Half life N/A
Excretion  ?
Therapeutic considerations
Pregnancy cat.

B(US)

Legal status

OTC(US)

Routes Topical
 Yes check.svgY(what is this?)  (verify)

Docosanol, also known as behenyl alcohol, is a saturated fatty alcohol[1] used traditionally as an emollient, emulsifier, and thickener in cosmetics[2][3][4], nutritional supplement (as an individual entity and also as a constituent of polyicosanol), and more recently, in an FDA-approved pharmaceutical, Abreva[5], approved for reducing the duration of "cold sores" caused by the herpes simplex virus (see antiviral agent).

Contents

Mechanism and history of antiviral drug usage

The presumed mechanism of action in Abreva is by inhibiting the fusion of the human host cell with the viral envelope of the herpes virus, thus preventing its replication. This mechanism has neither been directly observed nor proven, however.

Abreva was licensed as an oral herpes medicine after clinical trials by the U.S. Food and Drug Administration in July 2000.[6] It was shown to shorten the healing by 17.5 hours on average (95% confidence interval: 2 to 22 hours) in a placebo-controlled trial.[7] Three other trials showed negative results, but these were not published.[8]

Marketed by Avanir Pharmaceuticals, Abreva was the first over-the-counter antiviral drug approved for sale in the United States and Canada. In Europe, it is marketed by Healthcare Brands under the name Erazaban. In March 2007 it was the subject of a US nationwide class-action suit against Avanir and GlaxoSmithKline as the claim that it cut recovery times in half was found to have been misleading in a California court.[9]

See also

References

  1. ^ Katz DH, Marcelletti JF, Khalil MH, Pope LE, Katz LR (December 1991). "Antiviral activity of 1-docosanol, an inhibitor of lipid-enveloped viruses including herpes simplex". Proc. Natl. Acad. Sci. U.S.A. 88 (23): 10825–9. PMID 1660151. PMC 53024. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=1660151. 
  2. ^ http://fleur-s-cosmetics.stalgroup.com/
  3. ^ http://www.korresusa.com/product/4820/eye-cream/skincare/category/anti-aging-
  4. ^ http://www.avalonorganics.com/?id=124&show=B
  5. ^ mediLexicon: Docosanol
  6. ^ "Drug Name: ABREVA (docosanol) - approval". centerwatch.com. July 2000. http://www.centerwatch.com/patient/drugs/dru627.html. Retrieved 2007-10-17. 
  7. ^ Sacks, SL. Clinical efficacy of topical docosanol 10% cream for herpes simplex labialis: A multicenter, randomized, placebo-controlled trial. 45. J Am Acad Dermatol. pp. 222-230. 
  8. ^ Schubert-Zsilavecz, M, Wurglics, M, Neue Arzneimittel 2008/2009
  9. ^ "California Court Upholds Settlement Of Class Action Over Cold Sore Medicationl". BNA Inc.. July 2000. http://web.archive.org/web/20080205070115/http://subscript.bna.com/SAMPLES/plp.nsf/85256269004a991e8525611300214487/29d5bb623a50fd25852572ad0074f772?OpenDocument. Retrieved 2007-10-17. 

External links


 
 
Learn More
jojoba oil
Avanir Pharmaceuticals Inc
Docosanol Topical cream

Post a question - any question - to the WikiAnswers community:

 

Copyrights:

Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved.  Read more
Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Docosanol" Read more