Donald 'Deke' Slayton was selected in 1959 as one of the
original American Mercury 7 astronauts but before he could fly in
space he was found to suffer from a minor heart fibrilation.
Although still physically robust it was enough for flight
surgeons to remove Slayton from flight status and he never flew a
Mercury mission. He instead became chief of the astronaut office
and was responsible for choosing crews for the Gemini and Apollo
space programs.
In the early 1970's Slayton went back to the flight surgeons and
his fibrilation was found to have ceased. He was placed back on
flight status and in 1975 eventually did fly in space on board the
Apollo-Soyuz test project, the last flight of an Apollo
spacecraft.
Donald K Slayton thus did fly in space 16 years after being
selected as an astronaut.