Typically, the temporal lobe and limbic system are involved in
schizophrenia. Lesions, malformations, or simply dysfunction in
dopaminergic neurons of these areas of the brain can result in the
positive and negative symptoms of schizophrenia.
Since excess dopaminergic activity is indicative of
schizophrenia, antipsychotic drugs that block dopamine receptors
are the usual treatment for this illness.