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Dorzolamide

 
Drug Info: Dorzolamide

Brand names: Trusopt®

Chemical formula:



Dorzolamide Hydrochloride Ophthalmic drops, solution

What is this medicine?

DORZOLAMIDE is used in the eye to treat open-angle glaucoma and high pressure in the eye.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
•closed-angle glaucoma
•eye infection or damage
•kidney or liver disease
•wear contact lenses
•an unusual or allergic reaction to dorzolamide, sulfa drugs, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding

How should I use this medicine?

This medicine is only for use in the eye. Do not take by mouth. Follow the directions on the prescription label. Wash hands before and after use. Tilt the head back slightly and pull down the lower lid with the index finger to form a pouch. Try not to touch the tip of the dropper to your eye or any other surface. Squeeze the prescribed number of drops into the pouch. Close the eye gently. Do not blink. Use your doses at regular intervals. Do not use your medicine more often than directed. If you use other eye medicines, they should be used at least 10 minutes before or after this medicine.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What may interact with this medicine?

•carbonic anhydrase inhibitors like acetazolamide or methazolamide

Do not use any other eye products without telling your doctor or health care professional.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Stop using this medicine if your eyes get swollen, painful, or have a discharge, and see your doctor or health care professional as soon as you can.

If you wear contact lenses, take them out before using this medicine. Wait 15 minutes before putting them back into your eyes.

Wear dark glasses if this medicine makes your eyes more sensitive to light.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
•changes in vision
•fever
•infected eyes, lids
•muscle and joint aches
•redness, blistering, peeling or loosening of the skin, including inside the mouth
•unusual bleeding
•unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•bad taste in the mouth
•burning, stinging, or discomfort immediately after using the solution
•dry eyes
•increased flow of tears
•sensitivity of the eyes to light

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Throw away any unused medicine after the expiration date.

Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

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Veterinary Dictionary: dorzolamide
Top

A topical carbonic anhydrase inhibitor used in the treatment of glaucoma.

Wikipedia: Dorzolamide
Top
Dorzolamide
Systematic (IUPAC) name
(4S,6S)-2-ethylamino-4-methyl-5,5-dioxo-
6,7-dithiabicyclo[4.3.0]nona-8,10-diene-8-sulfonamide
Identifiers
CAS number 130693-82-2 120279-96-1
ATC code S01EC03
PubChem 3154
DrugBank APRD00577
Chemical data
Formula C10H16N2O4S3 
Mol. mass 324.443 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Protein binding ~33%
Metabolism  ?
Half life 4 months
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

Dorzolamide (trade name Trusopt) is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent and topically applied in the form of eye drops. This drug, developed by Merck, was the first drug in human therapy (market introduction 1995) which resulted from structure-based drug design. Dorzolamide hydrochloride is used to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.

The combination of dorzolamide with timolol is marketed under the trade name Cosopt.

References


Further reading

  • Kubinyi H (1999). "Chance favors the prepared mind--from serendipity to rational drug design". J Recept Signal Transduct Res 19 (1-4): 15–39. doi:10.3109/10799899909036635. PMID 10071748. 
  • Plummer C, MacKay E, Gelatt K (2006). "Comparison of the effects of topical administration of a fixed combination of dorzolamide-timolol to monotherapy with timolol or dorzolamide on IOP, pupil size, and heart rate in glaucomatous dogs.". Vet Ophthalmol 9 (4): 245–9. doi:10.1111/j.1463-5224.2006.00469.x. PMID 16771760. 
  • Grover S, Apushkin M, Fishman G (2006). "Topical dorzolamide for the treatment of cystoid macular edema in patients with retinitis pigmentosa.". Am J Ophthalmol 141 (5): 850–8. doi:10.1016/j.ajo.2005.12.030. PMID 16546110. 
  • Almeida G, Faria e Souza S (2006). "Effect of topical dorzolamide on rabbit central corneal thickness.". Braz J Med Biol Res 39 (2): 277–81. doi:10.1590/S0100-879X2006000200015. PMID 16470316. 

 
 

 

Copyrights:

Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved.  Read more
Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.  Read more
Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Dorzolamide" Read more