A central term in Buddhism which is not directly translatable in english. It's a type of unease. Birth is dukkha, aging is dukkha, death is dukkha; sorrow, lamentation, pain, distress, & despair are dukkha; association with what is not loved is dukkha, separation from what is loved is dukkha, not getting what is wanted is dukkha. In short, the five clinging-aggregates are dukkha.