Edward Seymour was the 1st Duke of Somerset and Jane Seymour's brother. He was Lord Protector of Edward VI until 1549. He was replaced by John Dudley, then Earl of Warwick. John Dudley became Duke of Northumberland and Lord President under Edward VI until Edward's death and the succession crisis of 1553.

Edward VI had two advisors, Edward Seymour, 1st Duke of Somerset, and then by John Dudley, the 1st Earl of Warwick, who later became Duke of Northumberland.

John Dudley, 1st Duke of Northumberland, and Edward Seymour, 1st Duke of Somerset, ruled as Lord Protectors over Edward VI, Henry VIII's son.

Jane Seymour (c1509 - 1537), the third wife of Henry VIII (1491 - 1537), and daughter of Sir John Seymour and Margery Wentworth; had the following brothers and sisters:

· John Seymour (died: 1510)

· Margery Seymour (1502 - 1520

· Edward Seymour, First Duke of Somerset (c1506 - 1552)

· Thomas Seymour, First Baron Seymour of Sudeley (c1508 - 1549)

· Elizabeth Seymour, the Marchioness of Winchester (c1513 - 1563)

· Sir Henry Seymour (c1514 - c1568)

· Dorothy Seymour

· Anthony Seymour