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A protein that speeds up the chemical reaction.

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A protein that speeds up the chemical reaction.

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substrate

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Shape.

When an enzyme is overheated the bonds between molecules that make up the enzyme breaks, this changes the shape of the enzyme's active site.

And as the enzyme is highly specific and would only work on one substrate which fits its active site, the enzyme will be totally denatured and won't activate anymore if it loses its shape.

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ase

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yeast

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