Enzyme multiplied immunoassay technique, or EMIT, is a common method for screening urine and blood for drugs, both legal or illicit. First introduced by Syva Company in 1973, it is the first homogeneous immunoassay to be widely used commercially.
A mix and read protocol has been developed that is exceptionally simple rapid. The most widely used applications for EMIT are for therapeutic drug monitoring (serum) and as a primary screen for abused drugs and their metabolites (urine). The US patents covering the major aspects of the method, 3,817,837 and 3,875,011, have expired. While still sold by Siemens Healthcare under its original tradename, EMIT, assay kits with different names that employ the same technology are supplied by other companies. The method is highly reliable and reliance on its results has been upheld by the US Supreme Court.
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