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Epididymitis

 
Medical Encyclopedia: Epididymitis
 

Definition

Epididymitis is inflammation or infection of the epididymis. In this long coiled tube attached to the upper part of each testicle, sperm mature and are stored before ejaculation.

Description

Epididymitis is the most common cause of pain in the scrotum. The acute form is usually associated with the most severe pain and swelling. If symptoms last for more than six weeks after treatment begins, the condition is considered chronic.

Epididymitis can occur any time after the onset of puberty but is most common between the ages of 18 and 40. It is especially common among members of the military who exercise for extended periods without emptying their bladders.

Factors that increase the risk of developing epididymitis include:

  • infection of the bladder, kidney, prostate, or urinary tract
  • other recent illness
  • narrowing of the urethra (the tube that drains urine from the bladder)
  • use of a urethral catheter.



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Sci-Tech Dictionary: epididymitis
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(′ep·ə′did·ə′mīd·əs)

(medicine) Inflammation of the epididymis.


 

Definition

Epididymitis is the inflammation or infection of the epididymis, the long coiled tube that attaches to the upper part of each testicle. The epididymis functions as a storage, transport, and maturation place for sperm before ejaculation.

Description

In adults, epididymitis is the most common cause of pain in the scrotum, and in adolescents, the second most common cause. The acute form is usually associated with the most severe pain and swelling. If symptoms last for more than six weeks after treatment begins, the condition is considered chronic.

Epididymitis is most common between the ages of 18 and 40, but children can get it, too. Boys who experience painful urination, have a history of urinary tract infections, abnormal bladder function, or abnormalities of the genitals and urinary structures are more inclined to get epididymitis. It is seldom found in adolescents who aren't sexually active.

The infection is especially common among members of the military who exercise for extended periods without emptying their bladders.

Factors that increase the risk of developing epididymitis include:

  • infection of the bladder, kidney, prostate, or urinary tract
  • other recent illness
  • narrowing of the urethra (the tube that drains urine from the bladder)
  • use of a urethral catheter

The infection doesn't start in the epididymis. It is an ascending infection that most often starts in the urethra or urinary tract before spreading to the epididymis.

Causes & Symptoms

Among men under age 35 who are sexually active, Chlamydia trachomatis or Neisseria gonorrhoeae are the most common causes of epididymitis.

Nonsexually transmitted epididymitis is associated with urinary tract infections and is more common in men who have undergone surgery for urinary tract problems or who have anatomical abnormalities.

Although epididymitis is often caused by and associated with some of the same organisms that cause some sexually transmitted diseases, there are other causes as well. The condition can also be attributed to pus-generating bacteria associated with infections in other parts of the body. This cause, however, is rare.

Epididymitis can also be caused by injury or infection of the scrotum or by irritation from urine that has accumulated in the vas deferens (the duct through which sperm travels after leaving the epididymis).

Epididymitis is characterized by pain in the testes. The pain, which usually develops gradually over several hours or days, is followed by sudden redness and swelling of the scrotum. Generally, only one testicle is affected. The affected testicle is hard and sore, and the other testicle may feel tender. The patient has chills, a low-grade fever, and usually has acute urethritis (inflammation of the urethra).

Sometimes, there is a discharge from the urethra and blood in the semen. Ejaculation can be painful.

Enlarged lymph nodes in the groin cause scrotal pain that intensifies throughout the day and may become so severe that walking normally becomes impossible.

Diagnosis

Doctors test for epididymitis through:

  • Urinalysis, which will likely show an elevated white blood-cell count and the presence of bacteria.
  • Urine culture, to identify the organism responsible for the infection.
  • Examination of discharges from the urethra and prostate gland.
  • Blood tests to measure white-cell counts, which will be elevated.
  • Ultrasound, which will reveal an enlarged epididymis.

The condition may lead to an abscess or cause such complications as infertility, so it is best to consult a urologist about the condition and treatment.

Treatment

Conventional treatment involves the use of antibiotics to treat the infection and pain killers to ease the pain. With alternative therapies, the treatment involves increasing circulation to the area. This reduces inflammation, which helps the body heal.

Fasting is recommended for some people, since digestion slows down the body's healing mechanisms. A water fast is best, but if that isn't possible, the patient should confine intake to fruit and vegetable juices. If food must be eaten, a light diet of fresh fruits and vegetables is recommended. Fasting eases pain. Fluids should also be increased.

In traditional Chinese medicine, there are formulas of herbs that need to be designed to fit the individual case. Herbs like philodendron (Huang Bai) are used for inflammation in the lower torso area. Pulsatilla, which helps with swelling and pain, particularly in the genitals, and podophyllum are the most effective in treating epididymitis. These plants, however, are toxic, and the herb should only be taken under the direct supervision of an experienced herbalist. Echinacea, horsetail, saw palmetto berries, cranberry extract, and chimaphilla are also effective.

Hydrotherapy may also help. Sitting in hot water increases circulation to the prostate area, alleviating discomfort and speeding recovery. Patients are advised to sit in a tub for 15 to 30 minutes once or twice a day. The water should be as hot as can be tolerated.

Homeopathy is also an option. Homeopathic physicians may prescribe remedies that are specific to the person.

Since epididymitis is caused by an infection and often involves the urinary tract, the following alternative remedies may also be helpful in treatment of the condition:

  • Acupuncture, which may help ward off another infection.
  • Aromatherapy. A hot sitz bath with drops of juniper berry or sandalwood may relieve symptoms of the infection.
  • Chiropractic. Strengthening bladder muscles by adjusting the joints and bones in the pelvic area may keep infection at bay.

Allopathic Treatment

Epididymitis is traditionally treated with antibiotic therapy. To prevent reinfection, patients must take their medication exactly as prescribed, even if the patient's symptoms disappear or if he begins to feel better. Over-the-counter anti-inflammatories may be taken to relieve pain. The over-the-counter medicines will have the same effects as herbal anti-inflammatories.

Bed rest is recommended until symptoms subside, and patients are advised to wear athletic supporters when they resume normal activities. If pain is severe, a local anesthetic like lidocaine (Xylocaine) may be injected directly into the spermatic cord. Scrotal ice packs and scrotal elevation are also recommended.

Self-Care

A patient who has epididymitis should not drink beverages that contain caffeine. To prevent constipation, he should use stool softeners or eat plenty of fruit, nuts, whole grain cereals, and other foods with laxative properties.

Strenuous activity should be avoided until symptoms disappear. Sexual activity should not be resumed until a month after symptoms disappear.

If a second course of treatment doesn't eradicate stubborn symptoms, long-term anti-inflammatory therapy may be recommended. In rare instances, chronic symptoms require surgery.

Surgery

There are two surgical procedures used to treat epididymitis, and both of them cause sterility.

Epididymectomy involves removing the inflamed section of the epididymitis through a small incision in the scrotum.

Bilateral vasectomy prevents fluid and sperm from passing through the epididymis. This procedure is usually performed on men who have chronic epididymitis or on elderly patients undergoing prostate surgery.

Before considering surgeries that will lead to infertility, patients may want to try alternative therapies.

Expected Results

Herbal preparations are very effective in treating epididymitis. Some sources say that given in medicinal doses, the herbs pulsatilla and podophyllum can treat epididymitis with the same results as conventional medicine.

Pain may begin to subside within 24 hours of treatment, but complete healing may take weeks or even months.

Prevention

Using condoms and not having sex with anyone who has a sexually transmitted disease (STD) can prevent some cases of epididymitis. Also, drinking plenty of fluids, which will increase urine flow, will help prevent urine retention, which can lead to infection.

Resources

Books

The Alternative Advisor. Alexandria, Virginia: Time-Life Books, 1997.

The Alternative Health and Medicine Encyclopedia. Detroit: Visible Ink Press, 1995.

The Medical Advisor. Alexandria, Virginia: Time-Life Books, 1996.

Shaw, Michael, ed. Everything You Need to Know About Diseases. Springhouse, Pennsylvania: Springhouse Corporation, 1996.

Periodicals

Baren, Jill M., "The Acute Scrotum: Serious or Benign?" Emergency Medicine 28, 8 (August 1996): 24-45.

Other

"Epididymitis." Adam.com.http://www.adam.com/ency/article/001279.htm (20 June 2000).

"Epididymitis." AlternativeMedicine.com.http://www.alternativemedicine.com (20 June 2000).

"Epididymitis." http://www.duj.com/epididymitis.html. (7 June 1998).

"Epididymitis." http://www.thriveonline.com/health/Library/illsymp/illness203.html. (6 June 1998).

[Article by: Lisa Frick]

 
Veterinary Dictionary: epididymitis
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Inflammation of the epididymis. Nonspecific epididymitis may result from an infection in the urinary tract, especially in the prostate. Rarely it may be traced to an infection elsewhere in the body. Specific epididymitides are those caused by Actinobacillus seminis and by Brucella ovis, both in rams, by B. canis in dogs, and the virus of epivag, bovine viral epididymitis and vaginitis in bulls.

 
Word Tutor: epididymitis
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pronunciation

IN BRIEF: n. - Painful inflammation of the elongated mass at the back of the testis composed chiefly of the greatly convoluted efferent tubes of that organ

 
Wikipedia: Epididymitis
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Epididymitis
Classification and external resources
1: Epididymis
2: Head of epididymis
3: Lobules of epididymis
4: Body of epididymis
5: Tail of epididymis
6: Duct of epididymis
7: Deferent duct (ductus deferens or vas deferens)
ICD-10 N45.0
ICD-9 604
DiseasesDB 4342
eMedicine med/704  radio/261 emerg/166
MeSH D004823

Epididymitis is a medical condition in which there is inflammation of the epididymis (a curved structure at the back of the testicle in which sperm matures and is stored). This condition may be mildly to very painful, and the scrotum (sac containing the testicles) may become red, warm and swollen. It may be acute (of sudden onset) or rarely chronic.

Epididymitis is the most frequent cause of sudden scrotal pain. In contrast with men who have testicular torsion, the cremaster reflex (elevation of the testicle in response to stroking the upper inner thigh) is not altered. If the diagnosis is not entirely clear from the patient's history and physical examination, a Doppler ultrasound scan can confirm increased flow of blood to the affected epididymis.

Infection is the most common cause. In sexually active men, Chlamydia trachomatis is the most frequent causative microbe, followed by E. coli and Neisseria gonorrhoeae. In children, it may follow an infection in another part of the body (for example, a viral illness), or there may be an associated urinary tract anomaly. Another cause is sterile reflux of urine through the ejaculatory ducts. Antibiotics may be needed to control a component of infection. Treatment otherwise comprises pain killers or anti-inflammatory drugs and bed rest if necessary, and symptom control by resting the scrotum in a supported position.

Contents

Diagnosis

Epididymitis can be hard to distinguish from testicular torsion. Both can occur at the same time. A urologist may need to be consulted.

Epididymitis usually has a gradual onset. On physical examination, the testicle is usually found to be in its normal vertical position, of equal size compared to its counterpart, and not high-riding. Typical findings are redness, warmth and swelling of the scrotum, with tenderness behind the testicle, away from the middle (this is the normal position of the epididymis relative to the testicle). The cremasteric reflex (if it was normal before) remains normal. This is a useful sign to distinguish it from testicular torsion. If there is pain relieved by elevation of the testicle, this is called Prehn's sign, which is however non-specific.

Analysis of the urine may or may not be normal. Before the advent of sophisticated medical imaging techniques, surgical exploration was the standard of care. Nowadays, color Doppler ultrasound is the preferred test. It can demonstrate increased blood flow (also compared to the normal side), as opposed to testicular torsion. Nuclear testicular blood flow testing is rarely used.

Additional tests may be necessary to identify underlying causes. In younger children, a urinary tract anomaly is frequently found. In sexually active men, tests for sexually transmitted diseases may be done. These may include microscopy and culture of a first void urine sample, Gram stain and culture of fluid or a swab from the urethra, nuclear acid amplification tests (to amplify and detect microbial DNA or other nucleic acids) or tests for syphillis and HIV.

Causes

Infection is the most common cause of epididymitis. The bacteria in the urethra back-track through the urinary and reproductive structures to the epididymis. There can be associated urethritis (inflammation of the urethra). Rarely, the infection reaches the epididymis via the bloodstream.

In sexually active men, Chlamydia trachomatis is responsible for two-thirds of cases, followed by Neisseria gonorrhoeae and E. coli (or other bacteria that cause urinary tract infection). Less common microbes include Ureaplasma, Mycobacterium, and cytomegalovirus, or Cryptococcus in patients with HIV infection. E. coli is more common in boys before puberty, the elderly and homosexual men.

Non-infectious causes are also possible. Reflux of sterile urine (urine without bacteria) through the ejaculatory ducts may cause inflammation with obstruction. In children, it may be a response following an infection with enterovirus, adenovirus or Mycoplasma pneumoniae.

Epididymitis can also be caused by genito-urinary surgery, including prostatectomy and urinary catheterization. Congestive epididymitis is a long-term complication of vasectomy.[1][2] Chemical epididymitis may also result from drugs such as amiodarone.[3]


Complications

Most cases with adequate treatment develop no complications and don't result in infertility. Untreated, acute epididymitis can lead to a variety of complications. These include chronic epididymitis, abscess, permanent damage or even destruction of the epididymis and testicle (resulting in infertility and/or hypogonadism), and infection may spread to any other organ or system of the body.


Treatment

Antibiotics are used if an infection is suspected. Fluoroquinolones are an option, although resistance of N. gonorrhoeae may limit their use. A cephalosporin (such as ceftriaxone) combined with doxycycline is an alternative. Azithromycin can be used for susceptible strains. In children, quinolones and doxycycline are best avoided. Since bacteria that cause urinary tract infections are often the cause of epididymitis in children, co-trimoxazole or suited penicillins (for example, cephalexin) can be used. If there is a sexually transmitted disease, the partner should also be treated.

Household remedies such as elevation of the scrotum and cold compresses applied regularly to the scrotum may relieve the pain. Painkillers or anti-inflammatory drugs are often necessary. Hospitalisation is indicated for severe cases, and check-ups can ensure the infection has cleared up. Surgery is rarely necessary, except, for example, in those rare instances where an abscess forms.

Epidemiology

Chronic epididymitis

Chronic epididymitis is epididymitis which ensues for more than six weeks. Chronic epididymitis is characterised by inflammation even when there is no infection present. Tests are needed to distinguish chronic epididymitis from a range of other disorders that can cause constant scrotal pain. These include testicular cancer, enlarged scrotal veins (varicocele) or a cyst within the epididymis. As well, the nerves in the scrotal area are connected to those of the abdomen, sometimes causing pain similar to a hernia (see referred pain). This condition can develop even without the presence of the previously described known causes.

Typically, a second, longer round of treatment is used. It is believed that the hypersensitivity of certain structures, including nerves and muscles, may cause or contribute to chronic epididymitis. A procedure called a cord block is a last measure. This consists of an injection into the nerve that traces along the epididymis. The injection is a compound of several medications including a steroid, pain killers, and a high dose of an anti-inflammatory. This treatment can quell the pain for 2-3 months in ideal conditions. Some patients may only experience an even shorter duration of 2-3 days, while the fortunate ones in rare occasions are never bothered again. This procedure would of course have to be repeated when necessary, until the problem goes away completely, or until the routine is simply too bothersome. As a last resort, a patient may then decide to have the epididymis completely removed.


Epididymitis in bulls

Epididymitis can be a concern in cattle herds. Bulls with epididymitis can spread bacteria to other cattle when they mount them. The cattle with epididymitis can often be detected early by the presence of white blood cells in their semen. In later stages, it can be detected by the swelling and hardening of the epididymis of the bull.


References

  1. ^ Schwingl PJ, Guess HA (2000). "Safety and effectiveness of vasectomy". Fertil. Steril. 73 (5): 923–36. doi:10.1016/S0015-0282(00)00482-9. PMID 10785217. 
  2. ^ Raspa RF (1993). "Complications of vasectomy". American family physician 48 (7): 1264–8. PMID 8237740. 
  3. ^ Ibsen HH, Frandsen F, Brandrup F, Møller M (August 1989). "Epididymitis caused by treatment with amiodarone". Genitourin Med 65 (4): 257–8. PMID 2807285. 

Further reading

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