Plasmid DNA is an extra-chromosomal DNA molecule, it cannot link
up with chromosomal DNA, and it contains the genetic informations
that are necessary for its own replication. Episomes is any kind of
extra-chromosomal DNA that can link up with chromosomal DNA. That
is the main difference between them two. Episomes are usually
larger than other extra-chromosomal DNA. An example of episome are
the viruses, because they intergrate their genetic material into
the host's chromosomal DNA.The only difference between the plasmid
and the episome is the integration i-e plasmid can not integrate
while episome can integrate into the genome.