- A letter, especially a formal one. See synonyms at letter.
- A literary composition in the form of a letter.
- Epistle Bible.
- One of the letters included as a book in the New Testament.
- An excerpt from one of these letters, read as part of a religious service.
[Middle English epistel, from Old French epistle, from Latin epistola, from Greek epistolē, from epistellein, to send a message to : epi-, epi- + stellein, to send.]





