ergosterol

Ergosterol is a sterol present in fungal cell membrane. Inhibitors such as Allylamines (Amorolfin,Butenafine,Naftifine,Terbinafine), Azole antifungal drugs (except for abafungin) inhibit ergosterol biosynthesis.
Effective drug Natamycin binds directly to ergosterol to limit fungal growth.

ergosterol

Ergosterol

Ergosterol, a cell membrane sterol, is found in the cell membrane of fungi, whereas the predominant sterol of bacteria and human cells is cholesterol. Anti fungal medications can bind to the ergosterol and create holes in the membrane allowing lysis of the cell or a secondary drug can be used to inhibit DNA and RNA synthesis. Some other drugs can inhibit ergosterol synthesis and also disrupt the cell membrane.