FIP-infected kidney showing inflammatory response
Feline infectious peritonitis (FIP) is a fatal, incurable disease that affects cats. It is believed by some to be caused by Feline Infectious Peritonitis Virus (FIPV), which is a mutation of Feline Enteric Coronavirus (FECV) - (Felin Coronavirus FeCoV). Although there appears to be a connection between FIP and feline coronavirus, no clear cause and effect has yet been proven. Experts do not always agree on the specifics of FIP. However, the most common theory is that the normally benign FECV mutates into FIPV. The mutated virus has the ability to invade and grow in certain white blood cells, namely macrophages. The immune system's response causes an intense inflammatory reaction in the containing tissues. This disease is generally fatal [1]. However its incidence rate is roughly 1 in 5000 for households with one or two cats. [2]
See also the special article about Felin Coronavirus
Transmission and infection
FECV is very common, especially in places where large groups of cats are kept together (animal shelters, catteries, etc). Cats become infected by inhaling or ingesting the virus. The most commonly cited transmission source is feces, although contaminated surfaces such as food dishes and clothing can transmit the virus as well.
Despite the prevalence of FECV, most infected cats do not develop FIP. Often, exposure to FECV produces no clinical signs, but may cause a mild diarrhea. Therefore, a cat without clinical signs may still be an FECV carrier and may pass the virus to another cat. In any cat infected with FECV there is a chance that the virus may mutate into the FIP causing form. This chance is increased for cats that are immune compromised including very young and very old cats. There is also thought to be a genetic component to susceptibility to viral mutation.
Signs
There are two main forms of FIP: effusive (wet) and non-effusive (dry). While both types are fatal, the effusive form is more common (60-70% of all cases are wet) and progresses more rapidly than the non-effusive form.
Effusive (wet)
The hallmark clinical sign of effusive FIP is the accumulation of fluid within the abdomen or chest, which can cause breathing difficulties. Other symptoms include lack of appetite, fever, weight loss, jaundice, and diarrhea.
Non-effusive (dry)
Dry FIP will also present with lack of appetite, fever, jaundice, diarrhea, and weight loss, but there will not be an accumulation of fluid. Typically a cat with dry FIP will show ocular or neurological signs. For example, the cat may develop difficulty in standing up or walking, becoming functionally paralyzed over time. Loss of vision is another possible outcome of the disease.
FIP Facts and Information
Diagnosis
The signs associated with FIP are often non-specific, which can cause diagnosis to be very difficult. There is as yet no definitive diagnostic test for FIP. Diagnosis may include a combination strong clinical suspicion, physical examination findings, presence of abdominal fluid with characteristic chemistry changes and examination of affected tissues for the FIP virus (this is usually performed post-mortem, but can be performed via tissue biopsy). Histopathological examination of tissue samples is usually the cheapest available diagnostic test, but its sensitivity and specificity for FIP is questionable. A polymerase chain reaction test is also available for use with fluid or certain tissue samples; however, its efficacy is currently being reviewed.
More commonly, a presumptive diagnosis is made based on clinical signs and evaluation of abdominal or chest fluid, if available. Fluid caused by FIP tends to be yellow in color and have elevated protein levels. Blood tests can also be performed to bolster a presumptive diagnosis by looking for coronavirus antibodies and elevated protein. Coronavirus titers are NOT considered diagnostic in and of themselves due to the ubiquity of FeCoV, but may be used in conjunction with clinical symptoms to make an FIP diagnosis. It is important to note that cats with higher titres of FCoV are no more likely to develop FIP than those with lower titres.
In the presence of abdominal or chest fluid, a simple test called Rivalta test, can be used to differentiate fluid resulting from FIP from fluids resulting from some other disease with very good accuracy.
Treatment
Accepted wisdom is that there is no cure for FIP; treatment is symptomatic and palliative only, i.e. typically the owner is advised to make the cat as comfortable as possible until it becomes clear that the cat is suffering. Prednisone or other immunosuppressive drugs prescribed by a veterinarian may help to prolong the cat's life for a few weeks or months, but may be contraindicated in certain cases due to concomitant infection(s), although this risk can be mitigated somewhat by also treating with antibiotics. Effusive FIP usually progresses too rapidly for any meaningful therapy to be attempted.
Quarantine is not necessary as FIP is not truly an infectious disease. Feline Enteric Coronavirus is shed in the feces and can be passed on to other cats, however, it is the mutated form of the virus that leads to FIP. This form is only found in macrophages and is therefore not shed and not contagious.
As FIP signs can be easily overlooked, it is highly advised to have your cat examined by your family veterinarian at any signs of abdominal distention, changes in the eyes, chronic diarrhea, unusual lethargy or respiratory infection. While treatment will only be symptomatic, it may prolong the life of the cat as well as soften the blow to the owner.FIP pateints can benefit from cytotoxic drugs such as methotrexate and cytoxan,and from corticosteroids such as methylprednisone or prednisolone;though it is not acure,it often improves appetite,weight,and can make the cat less leathargic.in some cases cytotoxic drugs can induce a breif remission,and even corticosteroids alone can give the cat 3-5 more months of good qualitiy life.in spite of these treatments,however,prognosis remains extremly poor.
See also
External links
