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Ferid Murad

 

(born Sept. 14, 1936, Whiting, Ind., U.S.) U.S. pharmacologist. He received his M.D. and Ph.D. from Western Reserve University (later Case Western Reserve University). Murad showed that nitroglycerin and related heart drugs induce the formation of nitric oxide, a gas that increases the diameter of blood vessels. Along with Robert F. Furchgott and Louis J. Ignarro, he was awarded a 1998 Nobel Prize for the discovery that nitric oxide acts as a signaling molecule in the cardiovascular system. Their combined work uncovered an entirely new mechanism for how blood vessels relax and widen. This discovery led to the development of the drug Viagra, which is used to treat erectile dysfunction.

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Scientist: Ferid Murad
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American physician and pharmacologist (1936–)

Murad was born in Whiting, Indiana, and graduated as an MD from the Western Reserve University School of Medicine, Cleveland, Ohio, in 1965. Three years later he gained his PhD from the department of pharmacology at the same university. He has held many important appointments; since 1988 he has worked at the Northwestern University Medical School, Chicago, Illinois. In 1998 he shared the Nobel Prize for physiology or medicine with Robert Furchgott and Louis Ignarro for their discovery that molecules of the gas nitrogen monoxide (nitric oxide, NO) can transmit signals in the cardiovascular system.

The hitherto unknown substance endothelium-derived relaxing factor (EDRF) had been discovered by Furchgott in 1980. Murad researched the action of glyceryl trinitrate (nitroglycerin) and related vasodilators, and in 1977 discovered that they release nitrogen monoxide, which relaxes the walls of smooth muscle cells. It thus has the effect of controlling the blood pressure and this is why glyceryl trinitrate is prescribed as a drug to treat the heart condition atherosclerosis (as ironically it once was for Alfred Nobel, who invented the nitroglycerin-containing dynamite). Murad also speculated that hormones and other endogenous factors might act in a similar way, although no evidence of this was forthcoming.

Wikipedia: Ferid Murad
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Ferid Murad

Murad at a lecture in 2008
Born September 14, 1936 (1936-09-14) (age 73)
Whiting, Indiana
Residence Houston, Texas
Citizenship United States
Ethnicity Albanian-American
Fields Biochemistry, Pharmacology
Institutions University of Virginia (1970-81), Stanford (1981-88), Abbott Laboratories (1988-93), University of Texas (1997-present)
Alma mater DePauw University (BS, 1958) and Case Western Reserve University (MD-Ph.D., 1965)
Doctoral advisor Earl Sutherland, Jr. and Theodore Rall
Known for Discoveries concerning nitric oxide as a signaling molecule in the cardiovascular system
Notable awards Nobel Prize in Physiology or Medicine (1998) and the Albert Lasker Award for Basic Medical Research (1996)
Religious stance Episcopalian

Ferid Murad (born September 14, 1936) is an Albanian-American physician and pharmacologist, and a co-winner of the 1998 Nobel Prize in Physiology or Medicine. He was born in Whiting, Indiana to John Murad (born Xhabir Murat Ejupi), an Albanian and Henrietta Bowman, an American. He received his undergraduate degree in chemistry from the pre-med program at DePauw University in 1958, and MD and pharmacology Ph.D. degrees from Case Western Reserve University in 1965; an early graduate of the first Medical Scientist Training Program to be developed. He then joined the University of Virginia, where he was made professor in 1970, before moving to Stanford in 1981. Murad left his tenure at Stanford in 1988 for a position at Abbott Laboratories, where he served as a vice president until starting his own biotechnology company, the Molecular Geriatrics Corporation, in 1993. The company experienced financial difficulties, and in 1997 Murad joined the University of Texas to create a new department of integrative biology, pharmacology, and physiology. He now continues at the University of Texas Health Science Center at Houston as Professor and Director Emeritus of The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseass and holds the John S. Dunn Distinguished Chair in Physiology and Medicine.

Murad's key research demonstrated that nitroglycerin and related drugs worked by releasing nitric oxide into the body, which acted as a signaling molecule in the cardiovascular system, making blood vessels dilate. The missing steps in the signaling process were filled in by Robert F. Furchgott and Louis J. Ignarro, for which the three shared the 1998 Nobel Prize (and for which Murad and Furchgott received the Albert Lasker Award for Basic Medical Research in 1996). There was some criticism, however, of the Nobel committee's decision not to award the prize to Salvador Moncada, who had independently reached the same results as Ignarro.

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