Natural sweeteners include corn sweeteners, sucrose processed from cane and beet sugars, or fructose

Fructose is a type of simple sugar. Some major sources of fructose are high fructose corn syrup, fruit and vegetables.

There are healthy sweeteners, like honey and stevia. There are also natural sugars in fruits. Table sugar, which is refined, and high fructose corn syrup (HFCS) are unhealthy. Artificial sweeteners are also unhealthy.

High fructose corn syrup, like other caloric sweeteners, contributes 4 calories per gram. It is not pure fructose. The most common types of high fructose corn syrup used in foods and beverages are HFCS-55 and HFCS-42. The number in the name denotes the percentage of fructose in the composition. So HFCS-55 is 55% fructose with the other 45% mainly glucose. HFCS-42 is 42% fructose with the other 58% mainly glucose. Most caloric sweeteners simply provide calories. Honey does have some protein, amino acids, vitamins and minerals, but all these components together add up to less than half of a percent (<0.5%). So you'd have to eat a lot to gain any nutritional benefit.