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Furazolidone

 
Drug Info: Furazolidone

Brand names: Furoxone®

Chemical formula:



Furazolidone tablets

What are furazolidone tablets?

FURAZOLIDONE (Furoxone®) is an antibiotic used to treat infectious diarrhea. Generic furazolidone tablets are available.

NOTE: This drug is discontinued in the US.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
• diabetes
• G6PD deficiency
• an unusual reaction to furazolidone, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should this medicine be used?

Take furazolidone tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a full glass of water. Furazolidone may be taken with or without food. Do not take this medication with tyramine containing foods (see below). Take your doses at regular intervals. Do not take your medicine more often than directed. Finish the full course prescribed by your prescriber or health care professional even if you think your condition is better. Do not stop taking except on your prescriber's advice.

What if I miss a dose?

If you miss a dose, take it as soon as possible. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. This medication should be taken at regular intervals.

What drug(s) may interact with furazolidone?

• alcohol
• buproprion
caffeine
cocaine
cyclobenzaprine
dextromethorphan
• diet pills, stimulants or amphetamine-like drugs
guarana
linezolid
• medicines for allergies, colds, hayfever, sinus, and breathing difficulties
• medicines for migraine (such as naratriptan, rizatriptan, sumatriptan, zolmitriptan or Midrin®)
• medicines for high blood pressure and heart medicines
• medicines called MAO inhibitors- examples: phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®)
• medicines for mental depression, anxiety, psychotic disturbances or other mental problems
meperidine
procarbazine
• some medications for Parkinson's disease, such as entacapone, levodopa or tolcapone
• St. John's wort, Hypericum perforatum
tramadol
• tryptophan
• tyramine—see below for foods that contain tyramine

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What should I watch for while taking furazolidone?

Tell your prescriber or health care professional if your symptoms do not begin to improve in a few days or get worse.

Because furazolidone may interact with many over-the-counter medications, you must check with your prescriber before taking any non-prescription medicines while on this antibiotic. Do not treat yourself for coughs, colds, or allergies. Do not take any medications for weight loss. Some ingredients in these products may increase possible side effects.

Furazolidone can interact with certain foods that contain tyramine to produce severe headaches, a rise in blood pressure, or irregular heart beat. Foods that contain significant amounts of tyramine include aged cheeses; meats and fish (especially aged, smoked, pickled, or processed such as bologna, pepperoni, salami, summer sausage); beer and ale; alcohol-free beer; wine (especially red); sherry; hard liquor; liqueurs; avocados; bananas; figs; raisins; soy sauce; miso soup; yeast/protein extracts; bean curd; fava or broad bean pods; or any over-ripe fruit. Ask your prescriber or health care professional, pharmacist, or nutritionist for a complete listing of tyramine-containing foods. Also, avoid drinks containing caffeine, such as tea, coffee, chocolate, or cola. These dietary restrictions should be followed during the course of therapy and should be continued for 4 days after therapy has been discontinued.

Avoid alcohol during and for up to 4 days after taking furazolidone. A serious syndrome (flushing, low blood pressure, slight temperature elevation, difficulty breathing or chest pain or discomfort) can occur.

Notify your health care professional if you are scheduled to have any surgery, procedure or medical testing (including myelography); tell your prescriber or health care professional that you have been taking furazolidone.

What side effects may I notice from receiving furazolidone?

Side effects that you should report to your prescriber or health care professional as soon as possible:
• chest discomfort or pain
• difficulty breathing
• fever
• flushing
• joint pain
• low or high blood pressure
• rash
• seizures (convulsions)
• weakness
• vomiting

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• headache
• nausea
• brown color to the urine

Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open.

Store at room temperature between 15—30 degrees C (59—86 degrees F). Keep the container tightly closed. Do not expose medication to sunlight. Throw away any unused medication after the expiration date.

Last updated: 12/3/2003 9:25:00 AM

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

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Veterinary Dictionary: furazolidone
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A nitrofuran antibiotic, used as a local antibacterial and antiprotozoal. Used in poultry and swine as a feed additive to treat bacterial and protozoal intestinal infections. Calves fed low levels of furazolidone over long periods develop a leukopenia, petechial hemorrhages everywhere and are susceptible to infection. It is usually a sequel to prophylactic feeding of antibiotics. See also granulocytopenic calf disease.

Wikipedia: Furazolidone
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Furazolidone
Systematic (IUPAC) name
3-{[(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one
Identifiers
CAS number 67-45-8
ATC code G01AX06
PubChem 5323714
DrugBank DB00614
Chemical data
Formula C8H7N3O5 
Mol. mass 225.16
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes Oral-Local
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Furazolidone is an antibacterial. It is marketed by Roberts Laboratories under the brand name Furoxone and by GlaxoSmithKline as Dependal-M.

Contents

Uses

It is used to treat diarrhoea and enteritis caused by bacteria or protozoan infections.

It has been used in aquaculture.[1]

Protozoan

Furazolidone is also used for Giardiasis (due to Giardia lamblia), though it is not a first line treatment.[2]

Bacterial

Furazolidone is also used to treat traveler's diarrhoea, cholera, and bacteremic salmonellosis.

As a veterinary medicine, furazolidone has been used with some success to treat salmonids for Myxobolus cerebralis infections.

Use in treating Helicobacter pylori infections has been proposed.[3]

Mechanism

It is believed to work by crosslinking of DNA.[4]

Side effects

Furazolidone is no longer available in the US. Though an effective antibiotic when all others fail, against extremely drug resistant infections, it has many side effects, and as with other nitrofurans generally, minimum inhibitory concentrations also produce systemic toxicity (tremors, convulsions, periferal neuritis, gastrointestinal disturbances, depression of spermatogenesis.) Nitrofurans are recognized by FDA as mutagens/carcinogens, and can no longer be used since 1991. [5]

References

  1. ^ Meng J, Mangat SS, Grudzinski IP, Law FC (1998). "Evidence of 14C-furazolidone metabolite binding to the hepatic DNA of trout". Drug Metabol Drug Interact 14 (4): 209–19. PMID 10694929. 
  2. ^ Petri WA (February 2005). "Treatment of Giardiasis". Curr Treat Options Gastroenterol 8 (1): 13–17. PMID 15625030. http://www.treatment-options.com/1092-8472/8/13. 
  3. ^ Machado RS, Silva MR, Viriato A (2008). "Furazolidone, tetracycline and omeprazole: a low-cost alternative for Helicobacter pylori eradication in children". Jornal de pediatria 84 (2): 160–5. doi:doi:10.2223/JPED.1772. PMID 18372934. http://dx.doi.org/doi:10.2223/JPED.1772. 
  4. ^ "DrugBank: Showing Furazolidone (DB00614)". http://www.drugbank.ca/drugs/DB00614. Retrieved 2008-12-19. 
  5. ^ http://caraga.da.gov.ph/services/banmed-Nitrofurans.htm

 
 
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Copyrights:

Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved.  Read more
Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.  Read more
Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Furazolidone" Read more