Tay–Sachs disease is also known as GM2 gangliosidosis or hexosaminidase A deficiency. Other names are: B variant GM2 gangliosidosis, GM2 gangliosidosis, type 1, Hexosaminidase alpha-subunit deficiency (variant B), Sphingolipidosis, Tay-Sachs and TSD.

Yes! Tay-Sachs is also known as GM2 gangliosidosis or Hexosaminidase A deficiency.

Tay-Sachs disease is abbreviated to TSD and is also known as GM2 gangliosidosis or Hexosaminidase A deficiency.

In Tay- Sach's disease, hydrolysis of GM2-ganglioside requires 3 proteins.

Two of them are subunits of hexosaminidase A, and the third is a small glycolipid transport protein, the GM2 activator protein (GM2A), which acts as a substrate specific cofactor for the enzyme. Deficiency in any one of these proteins leads to storage of the ganglioside, primarily in the lysosomes of neuronal cells. Tay-Sachs disease (along with GM2-gangliosidosis and Sandhoff disease) occurs because a genetic mutation inherited from both parents deactivates or inhibits this process. Most Tay-Sachs mutations appear not to affect functional elements of the protein. Instead, they cause incorrect folding or assembly of the enzyme, so that intracellular transport is disabled.

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