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Gemfibrozil

 
Dental Dictionary: gemfibrozil

n

trade name: Lopid; drug class: antihyperlipidemic; action: reduces plasma triglycerides and very low density lipoproteins; uses: type IIb, IV, and V hyperlipidemia.

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Drug Info: Gemfibrozil
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Brand names: Lopid®

Chemical formula:



Gemfibrozil Oral tablet

What is this medicine?

GEMFIBROZIL (jem FI broe zil) can help lower blood fats and cholesterol for people who are at risk of getting inflammation of the pancreas (pancreatitis) from having very high amounts of fats in their blood. This medicine is only for patients whose blood fats are not controlled by diet.
 
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
•cataracts
•gallbladder disease
•heart disease
•kidney or liver disease
•an unusual or allergic reaction to gemfibrozil, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine 30 minutes before a meal. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine except on the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
•bexarotene
•ezetimibe
•other cholesterol medicines like clofibrate and fenofibrate
•repaglinide
•statin-type cholesterol lowering drugs like atorvastatin, cerivastatin, fluvastatin, lovastatin, pravastatin, or simvastatin

This medicine may also interact with the following medications:
•warfarin
•red yeast rice

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Your blood fats and other tests will be measured from time to time.

This medicine is only part of a total cholesterol-lowering program. Your health care professional or dietician can suggest a low-cholesterol and low-fat diet that will reduce your risk of getting heart and blood vessel disease. Avoid alcohol and smoking, and keep a proper exercise schedule.

If you are diabetic, close regulation and monitoring of your blood sugars can help your blood fat levels. This medicine may change the way your diabetic medicine works, and sometimes will require that your dosages be adjusted. Check with your doctor or health care professional.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
•cold or flu-like symptoms
•dark yellow or brown urine
•lower back or side pain
•muscle pain
•pain or difficulty passing urine
•stomach pain with nausea and vomiting
•unusual tiredness
•yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•blurred vision
•decreased sexual function or desire
•headache
•stomach gas, heartburn

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from light and humidity. Throw away any unused medicine after the expiration date.

Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

Medical Dictionary: gem·fi·bro·zil
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(jĕm-fī'brə-zĭl, -fĭb'rə-)
n.

An antihyperlipidemic agent used in the treatment of very high serum triglyceride levels.

WordNet: gemfibrozil
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Note: click on a word meaning below to see its connections and related words.

The noun has one meaning:

Meaning #1: medication (trade name Lopid) used to lower the levels of triglyceride in the blood
  Synonym: Lopid


Wikipedia: Gemfibrozil
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Gemfibrozil
Systematic (IUPAC) name
5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoic acid
Identifiers
CAS number 25812-30-0
ATC code C10AB04
PubChem 3463
DrugBank APRD00293
ChemSpider 3345
Chemical data
Formula C15H22O3 
Mol. mass 250.333 g/mol
Pharmacokinetic data
Bioavailability Close to 100%
Protein binding 95%
Metabolism Hepatic (CYP3A4)
Half life 1.5 hours
Excretion Renal 94%
Feces 6%
Therapeutic considerations
Pregnancy cat.

Category C

Legal status

By Prescription

Routes Oral
 Yes check.svgY(what is this?)  (verify)

Gemfibrozil is the generic name for an oral drug used to lower lipid levels. It belongs to a group of drugs known as fibrates. It is most commonly sold as the brand name, Lopid. Other brand names include Jezil and Gen-Fibro.

Contents

Actions

Therapeutic effects

Nontherapeutic effects and toxicities

Indications

Contraindications and Precautions

  • Gemfibrozil should not be given to these patients:
    • Hepatic dysfunction
    • Renal dysfunction
  • Gemfibrozil should be used with caution in these higher risk categories:
    • Biliary Tract Disease
    • Pregnant women
    • Obese patients
    • Native Americans

Drug Interactions

  • Anticoagulants: Gemfibrozil potentiates the action of coumadin and indanedione anticoagulants.
  • Statin drugs: Concomitant administration of fibrates (including gemfibrozil) with statin drugs increases the risk of muscle cramping, myopathy, and rhabdomyolysis.

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Copyrights:

Dental Dictionary. Mosby's Dental Dictionary. Copyright © 2004 by Elsevier, Inc. All rights reserved.  Read more
Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved.  Read more
Medical Dictionary. The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company Read more
WordNet. WordNet 1.7.1 Copyright © 2001 by Princeton University. All rights reserved.  Read more
Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Gemfibrozil" Read more