Geminal halide hydrolysis is an organic reaction. The reactants are a geminal dihalide and water or a hydroxide. The reaction product is a ketone or an aldehyde. The first part of the reaction mechanism consists of an ordinary nucleophilic aliphatic substitution to produce a gem-halohydrin. The remaining halide is a good leaving group and this enables the newly created hydroxy group to revert to a carbonyl group expelling the halide. Similar reactions involving any strong electronegative functional group, such as a nitrile, in place of the halide also occur.
In a similar fashion 1,1,1-trihalides are hydrolyzed to carboxylic acids in the haloform reaction.
External links
- Benzophenone synthesis from benzene through benzophenone dichloride in Organic Syntheses Coll. Vol. 1, p.95; Vol. 8, p.26 Article
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